Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy

DNA double stranded breaks (DSBs) are the most serious type of lesions introduced into chromatin by ionizing radiation. During DSB repair, cells recruit different proteins to the damaged sites in a manner dependent on local chromatin structure, DSB location in the nucleus, and the repair pathway ent...

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Veröffentlicht in:	International journal of molecular sciences 2018-11, Vol.19 (12), p.3713
Hauptverfasser:	Bobkova, Elizaveta, Depes, Daniel, Lee, Jin-Ho, Jezkova, Lucie, Falkova, Iva, Pagacova, Eva, Kopecna, Olga, Zadneprianetc, Mariia, Bacikova, Alena, Kulikova, Elena, Smirnova, Elena, Bulanova, Tatiana, Boreyko, Alla, Krasavin, Evgeny, Wenz, Frederik, Bestvater, Felix, Hildenbrand, Georg, Hausmann, Michael, Falk, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapies Cell cycle Cell Line, Tumor Cells, Cultured Chromatin Cosmic rays Deoxyribonucleic acid DNA DNA damage DNA repair Double-strand break repair Efficiency Genomes Glioblastoma Glioblastoma cells Humans Ionizing radiation Light microscopy Localization Microscopy Microscopy, Confocal - methods Molecular biology Neonates Nuclei Nuclei (cytology) Optical microscopy Post-irradiation Protein Transport Proteins Radiation Radiation damage Recombinational DNA Repair Recruitment Repair Single Molecule Imaging - methods Spatial distribution Tags Tumor Suppressor p53-Binding Protein 1 - metabolism
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