Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma
Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a...
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| Veröffentlicht in: | International journal of molecular sciences 2018-12, Vol.19 (12), p.3996 |
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| creator | Jung, Ah Ra Eun, Young-Gyu Lee, Young Chan Noh, Joo Kyung Kwon, Kee Hwan |
| description | Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. We analyzed the frequency of somatic mutations, clinicopathologic characteristics, association with immunotherapy-related gene signatures, and the pathways of gene signatures. We found 363 CSMD1-related genes. The prognosis of the CSMD1-inactivated subgroup was poor.
,
,
,
,
, and
had higher mutation rates in the CSMD1-inactivated subgroups. The Interferon-gamma score and immune signature score were elevated in CSMD1-inactivated subgroups. We identified several CSMD1-related pathways, such as the phosphatidylinositol signaling system and inositol phosphate metabolism. Our study using three large and independent datasets suggests that CSMD1-related gene signatures are associated with the prognosis of HNSCC patients. |
| doi_str_mv | 10.3390/ijms19123996 |
| format | Article |
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,
,
,
,
, and
had higher mutation rates in the CSMD1-inactivated subgroups. The Interferon-gamma score and immune signature score were elevated in CSMD1-inactivated subgroups. We identified several CSMD1-related pathways, such as the phosphatidylinositol signaling system and inositol phosphate metabolism. Our study using three large and independent datasets suggests that CSMD1-related gene signatures are associated with the prognosis of HNSCC patients.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms19123996</identifier><identifier>PMID: 30545040</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Cancer ; Cdc4 protein ; Cell cycle ; Chromosomes ; Clinical significance ; Datasets ; Domains ; Frequency analysis ; Gene expression ; Genes ; Genomes ; Head & neck cancer ; Histocompatibility antigen HLA ; Human papillomavirus ; Immunotherapy ; Inositol phosphate ; Inositol phosphates ; Interferon ; Larynx ; Medical prognosis ; Metastasis ; Mutation ; Mutation rates ; p53 Protein ; Pathogenesis ; Phosphatidylinositol ; Prognosis ; Squamous cell carcinoma ; Subgroups ; γ-Interferon</subject><ispartof>International journal of molecular sciences, 2018-12, Vol.19 (12), p.3996</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-3d772136ccfe9436d7ddff426a029dd309675a65864b39076fed730068de1af73</citedby><cites>FETCH-LOGICAL-c478t-3d772136ccfe9436d7ddff426a029dd309675a65864b39076fed730068de1af73</cites><orcidid>0000-0003-4081-5207 ; 0000-0001-5647-1184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321139/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321139/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30545040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Ah Ra</creatorcontrib><creatorcontrib>Eun, Young-Gyu</creatorcontrib><creatorcontrib>Lee, Young Chan</creatorcontrib><creatorcontrib>Noh, Joo Kyung</creatorcontrib><creatorcontrib>Kwon, Kee Hwan</creatorcontrib><title>Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. We analyzed the frequency of somatic mutations, clinicopathologic characteristics, association with immunotherapy-related gene signatures, and the pathways of gene signatures. We found 363 CSMD1-related genes. The prognosis of the CSMD1-inactivated subgroup was poor.
,
,
,
,
, and
had higher mutation rates in the CSMD1-inactivated subgroups. The Interferon-gamma score and immune signature score were elevated in CSMD1-inactivated subgroups. We identified several CSMD1-related pathways, such as the phosphatidylinositol signaling system and inositol phosphate metabolism. Our study using three large and independent datasets suggests that CSMD1-related gene signatures are associated with the prognosis of HNSCC patients.</description><subject>Cancer</subject><subject>Cdc4 protein</subject><subject>Cell cycle</subject><subject>Chromosomes</subject><subject>Clinical significance</subject><subject>Datasets</subject><subject>Domains</subject><subject>Frequency analysis</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Head & neck cancer</subject><subject>Histocompatibility antigen HLA</subject><subject>Human papillomavirus</subject><subject>Immunotherapy</subject><subject>Inositol phosphate</subject><subject>Inositol phosphates</subject><subject>Interferon</subject><subject>Larynx</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Mutation rates</subject><subject>p53 Protein</subject><subject>Pathogenesis</subject><subject>Phosphatidylinositol</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Subgroups</subject><subject>γ-Interferon</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUlP5DAQhS0EAga4cUaWuHCgwVvs-IIEYVgklkPD2TJewE1iN3GCxL8fMyxqOFVJ9dVTvXoAbGN0QKlEh2HWZSwxoVLyJbCOGSEThLhYXujXwJ-cZwgRSiq5CtYoqliFGFoHqWlDDEa3cBoeY_CljcbB5GFzfwJ1tHA65qcAr8d2CPPWwdPU6RAzxPAyajOEVz2EFGGI8MJp-3_jxplnOH0ZdZfGDBvXtrDRvQmxrG6CFa_b7LY-6wa4P_t711xMrm7PL5vjq4lhoh4m1ApBMOXGeCcZ5VZY6z0jXCMiraVIclFpXtWcPZQnCO6dFbRYra3D2gu6AY4-dOfjQ-escXHodavmfeh0_6aSDurnJIYn9ZheFacEYyqLwN6nQJ9eRpcH1YVsihcdXbGlCK4EFwxzVtDdX-gsjX0s9hSpalJXrLy9UPsflOlTzr3z38dgpN6TVItJFnxn0cA3_BUd_QcOjJlK</recordid><startdate>20181212</startdate><enddate>20181212</enddate><creator>Jung, Ah Ra</creator><creator>Eun, Young-Gyu</creator><creator>Lee, Young Chan</creator><creator>Noh, Joo Kyung</creator><creator>Kwon, Kee Hwan</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4081-5207</orcidid><orcidid>https://orcid.org/0000-0001-5647-1184</orcidid></search><sort><creationdate>20181212</creationdate><title>Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma</title><author>Jung, Ah Ra ; Eun, Young-Gyu ; Lee, Young Chan ; Noh, Joo Kyung ; Kwon, Kee Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-3d772136ccfe9436d7ddff426a029dd309675a65864b39076fed730068de1af73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer</topic><topic>Cdc4 protein</topic><topic>Cell cycle</topic><topic>Chromosomes</topic><topic>Clinical significance</topic><topic>Datasets</topic><topic>Domains</topic><topic>Frequency analysis</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Head & neck cancer</topic><topic>Histocompatibility antigen HLA</topic><topic>Human papillomavirus</topic><topic>Immunotherapy</topic><topic>Inositol phosphate</topic><topic>Inositol phosphates</topic><topic>Interferon</topic><topic>Larynx</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Mutation rates</topic><topic>p53 Protein</topic><topic>Pathogenesis</topic><topic>Phosphatidylinositol</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Subgroups</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Ah Ra</creatorcontrib><creatorcontrib>Eun, Young-Gyu</creatorcontrib><creatorcontrib>Lee, Young Chan</creatorcontrib><creatorcontrib>Noh, Joo Kyung</creatorcontrib><creatorcontrib>Kwon, Kee Hwan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Ah Ra</au><au>Eun, Young-Gyu</au><au>Lee, Young Chan</au><au>Noh, Joo Kyung</au><au>Kwon, Kee Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2018-12-12</date><risdate>2018</risdate><volume>19</volume><issue>12</issue><spage>3996</spage><pages>3996-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. We analyzed the frequency of somatic mutations, clinicopathologic characteristics, association with immunotherapy-related gene signatures, and the pathways of gene signatures. We found 363 CSMD1-related genes. The prognosis of the CSMD1-inactivated subgroup was poor.
,
,
,
,
, and
had higher mutation rates in the CSMD1-inactivated subgroups. The Interferon-gamma score and immune signature score were elevated in CSMD1-inactivated subgroups. We identified several CSMD1-related pathways, such as the phosphatidylinositol signaling system and inositol phosphate metabolism. Our study using three large and independent datasets suggests that CSMD1-related gene signatures are associated with the prognosis of HNSCC patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30545040</pmid><doi>10.3390/ijms19123996</doi><orcidid>https://orcid.org/0000-0003-4081-5207</orcidid><orcidid>https://orcid.org/0000-0001-5647-1184</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer Cdc4 protein Cell cycle Chromosomes Clinical significance Datasets Domains Frequency analysis Gene expression Genes Genomes Head & neck cancer Histocompatibility antigen HLA Human papillomavirus Immunotherapy Inositol phosphate Inositol phosphates Interferon Larynx Medical prognosis Metastasis Mutation Mutation rates p53 Protein Pathogenesis Phosphatidylinositol Prognosis Squamous cell carcinoma Subgroups γ-Interferon |
| title | Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma |
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