Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem ® -C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived neurotrophic factor...

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Veröffentlicht in:	International journal of molecular sciences 2018-11, Vol.19 (12), p.3782
Hauptverfasser:	Ravina, Kristine, Briggs, Denise I, Kislal, Sezen, Warraich, Zuha, Nguyen, Tiffany, Lam, Rachel K, Zarembinski, Thomas I, Shamloo, Mehrdad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-brain barrier Brain injury Brain-derived neurotrophic factor Cell growth Cerebral blood flow Cerebral infarction Corpus striatum Drug therapy Hydrogels Inflammation Injury prevention Ischemia Kinases Medical prognosis Membrane permeability Neostriatum Recovery of function Sensorimotor system Stem cells Stroke
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