Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study
Aim Our study aimed to evaluate the early neurodevelopmental outcomes of very low birthweight (VLBW) neonates with culture-proven sepsis compared with VLBW neonates without sepsis. Materials and methods Our study included 80 VLBW neonates with blood culture-proven sepsis and 80 VLBW neonates without...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2018-10, Vol.10 (10), p.e3492-e3492 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e3492 |
|---|---|
| container_issue | 10 |
| container_start_page | e3492 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 10 |
| creator | Singh, Laxman Das, Sarthak Bhat, Vishnu B Plakkal, Nishad |
| description | Aim Our study aimed to evaluate the early neurodevelopmental outcomes of very low birthweight (VLBW) neonates with culture-proven sepsis compared with VLBW neonates without sepsis. Materials and methods Our study included 80 VLBW neonates with blood culture-proven sepsis and 80 VLBW neonates without sepsis. For each neonate with sepsis, a control neonate of matching gender and gestational age was selected. We evaluated weight, length, and head circumference and conducted Hammersmith neonatal neurological examinations for each participant. We also conducted Developmental Assessment Screening II and vision and hearing impairment screening during a follow-up evaluation. Results We noted a developmental delay in 11 (23.4%) neonates with sepsis and two (3%) without sepsis at six months of age. The median developmental quotient, motor quotient, and mental quotients were significantly lower in the neonates with sepsis compared to those without sepsis. Conclusions Our findings suggest that sepsis significantly affects mortality and neurodevelopmental outcomes at six months in VLBW neonates. Therefore, preventive measures for sepsis in VLBW neonates is crucial, and those with culture-positive sepsis will require close monitoring and follow-up evaluations. |
| doi_str_mv | 10.7759/cureus.3492 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6318141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2174139490</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-394e2be03cc91bb0109bab384794c32cba3538ed2a2d4a237cd8460f6d2005f53</originalsourceid><addsrcrecordid>eNpdkUtr3DAUhU1paEKaVfdF0E2hONVrbKmLQjKkSWBICn1shSxfxwq25eoxw_yF_upqmDQkWekKffdwjk5RvCP4tK4X8rNJHlI4ZVzSV8URJZUoBRH89ZP5sDgJ4R5jTHBNcY3fFIcMV1xgxo-KvxfaD1t0A8m7FtYwuHmEKeoB3aZo3AjIdeg3-C1auQ06tz72G7B3fcwrbtIRAtrY2KNlGmK2Us4u2GjXgM4H51r0I3rQI7qeOjDRuukLOkPfvQvz7pqppeudjxlL7fZtcdDpIcDJw3lc_Pp28XN5Va5uL6-XZ6vSMCZjySQH2gBmxkjSNDmVbHTDBK8lN4yaRrMFE9BSTVuuKatNK3iFu6qlGC-6BTsuvu5159SM0Joc1-tBzd6O2m-V01Y9f5lsr-7cWlWMCMJJFvj4IODdnwQhqtEGA8OgJ3ApKEpqyUSFhczohxfovUt-yvF2VNaSXOJMfdpTJn9N8NA9miFY7WpW-5rVruZMv3_q_5H9Xyr7B4SEpzM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2174139490</pqid></control><display><type>article</type><title>Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Singh, Laxman ; Das, Sarthak ; Bhat, Vishnu B ; Plakkal, Nishad</creator><creatorcontrib>Singh, Laxman ; Das, Sarthak ; Bhat, Vishnu B ; Plakkal, Nishad</creatorcontrib><description>Aim Our study aimed to evaluate the early neurodevelopmental outcomes of very low birthweight (VLBW) neonates with culture-proven sepsis compared with VLBW neonates without sepsis. Materials and methods Our study included 80 VLBW neonates with blood culture-proven sepsis and 80 VLBW neonates without sepsis. For each neonate with sepsis, a control neonate of matching gender and gestational age was selected. We evaluated weight, length, and head circumference and conducted Hammersmith neonatal neurological examinations for each participant. We also conducted Developmental Assessment Screening II and vision and hearing impairment screening during a follow-up evaluation. Results We noted a developmental delay in 11 (23.4%) neonates with sepsis and two (3%) without sepsis at six months of age. The median developmental quotient, motor quotient, and mental quotients were significantly lower in the neonates with sepsis compared to those without sepsis. Conclusions Our findings suggest that sepsis significantly affects mortality and neurodevelopmental outcomes at six months in VLBW neonates. Therefore, preventive measures for sepsis in VLBW neonates is crucial, and those with culture-positive sepsis will require close monitoring and follow-up evaluations.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.3492</identifier><identifier>PMID: 30648034</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age ; Birth weight ; Births ; Cerebral palsy ; Cohort analysis ; Health education ; Health risk assessment ; Hemorrhage ; Low income groups ; Mortality ; Neurology ; Newborn babies ; Pediatrics ; Preventive Medicine ; Sepsis ; Statistical analysis ; Ventilators</subject><ispartof>Curēus (Palo Alto, CA), 2018-10, Vol.10 (10), p.e3492-e3492</ispartof><rights>Copyright © 2018, Singh et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2018, Singh et al. 2018 Singh et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-394e2be03cc91bb0109bab384794c32cba3538ed2a2d4a237cd8460f6d2005f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318141/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318141/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30648034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Laxman</creatorcontrib><creatorcontrib>Das, Sarthak</creatorcontrib><creatorcontrib>Bhat, Vishnu B</creatorcontrib><creatorcontrib>Plakkal, Nishad</creatorcontrib><title>Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Aim Our study aimed to evaluate the early neurodevelopmental outcomes of very low birthweight (VLBW) neonates with culture-proven sepsis compared with VLBW neonates without sepsis. Materials and methods Our study included 80 VLBW neonates with blood culture-proven sepsis and 80 VLBW neonates without sepsis. For each neonate with sepsis, a control neonate of matching gender and gestational age was selected. We evaluated weight, length, and head circumference and conducted Hammersmith neonatal neurological examinations for each participant. We also conducted Developmental Assessment Screening II and vision and hearing impairment screening during a follow-up evaluation. Results We noted a developmental delay in 11 (23.4%) neonates with sepsis and two (3%) without sepsis at six months of age. The median developmental quotient, motor quotient, and mental quotients were significantly lower in the neonates with sepsis compared to those without sepsis. Conclusions Our findings suggest that sepsis significantly affects mortality and neurodevelopmental outcomes at six months in VLBW neonates. Therefore, preventive measures for sepsis in VLBW neonates is crucial, and those with culture-positive sepsis will require close monitoring and follow-up evaluations.</description><subject>Age</subject><subject>Birth weight</subject><subject>Births</subject><subject>Cerebral palsy</subject><subject>Cohort analysis</subject><subject>Health education</subject><subject>Health risk assessment</subject><subject>Hemorrhage</subject><subject>Low income groups</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Newborn babies</subject><subject>Pediatrics</subject><subject>Preventive Medicine</subject><subject>Sepsis</subject><subject>Statistical analysis</subject><subject>Ventilators</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUtr3DAUhU1paEKaVfdF0E2hONVrbKmLQjKkSWBICn1shSxfxwq25eoxw_yF_upqmDQkWekKffdwjk5RvCP4tK4X8rNJHlI4ZVzSV8URJZUoBRH89ZP5sDgJ4R5jTHBNcY3fFIcMV1xgxo-KvxfaD1t0A8m7FtYwuHmEKeoB3aZo3AjIdeg3-C1auQ06tz72G7B3fcwrbtIRAtrY2KNlGmK2Us4u2GjXgM4H51r0I3rQI7qeOjDRuukLOkPfvQvz7pqppeudjxlL7fZtcdDpIcDJw3lc_Pp28XN5Va5uL6-XZ6vSMCZjySQH2gBmxkjSNDmVbHTDBK8lN4yaRrMFE9BSTVuuKatNK3iFu6qlGC-6BTsuvu5159SM0Joc1-tBzd6O2m-V01Y9f5lsr-7cWlWMCMJJFvj4IODdnwQhqtEGA8OgJ3ApKEpqyUSFhczohxfovUt-yvF2VNaSXOJMfdpTJn9N8NA9miFY7WpW-5rVruZMv3_q_5H9Xyr7B4SEpzM</recordid><startdate>20181024</startdate><enddate>20181024</enddate><creator>Singh, Laxman</creator><creator>Das, Sarthak</creator><creator>Bhat, Vishnu B</creator><creator>Plakkal, Nishad</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181024</creationdate><title>Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study</title><author>Singh, Laxman ; Das, Sarthak ; Bhat, Vishnu B ; Plakkal, Nishad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-394e2be03cc91bb0109bab384794c32cba3538ed2a2d4a237cd8460f6d2005f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Birth weight</topic><topic>Births</topic><topic>Cerebral palsy</topic><topic>Cohort analysis</topic><topic>Health education</topic><topic>Health risk assessment</topic><topic>Hemorrhage</topic><topic>Low income groups</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Newborn babies</topic><topic>Pediatrics</topic><topic>Preventive Medicine</topic><topic>Sepsis</topic><topic>Statistical analysis</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Laxman</creatorcontrib><creatorcontrib>Das, Sarthak</creatorcontrib><creatorcontrib>Bhat, Vishnu B</creatorcontrib><creatorcontrib>Plakkal, Nishad</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Laxman</au><au>Das, Sarthak</au><au>Bhat, Vishnu B</au><au>Plakkal, Nishad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2018-10-24</date><risdate>2018</risdate><volume>10</volume><issue>10</issue><spage>e3492</spage><epage>e3492</epage><pages>e3492-e3492</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Aim Our study aimed to evaluate the early neurodevelopmental outcomes of very low birthweight (VLBW) neonates with culture-proven sepsis compared with VLBW neonates without sepsis. Materials and methods Our study included 80 VLBW neonates with blood culture-proven sepsis and 80 VLBW neonates without sepsis. For each neonate with sepsis, a control neonate of matching gender and gestational age was selected. We evaluated weight, length, and head circumference and conducted Hammersmith neonatal neurological examinations for each participant. We also conducted Developmental Assessment Screening II and vision and hearing impairment screening during a follow-up evaluation. Results We noted a developmental delay in 11 (23.4%) neonates with sepsis and two (3%) without sepsis at six months of age. The median developmental quotient, motor quotient, and mental quotients were significantly lower in the neonates with sepsis compared to those without sepsis. Conclusions Our findings suggest that sepsis significantly affects mortality and neurodevelopmental outcomes at six months in VLBW neonates. Therefore, preventive measures for sepsis in VLBW neonates is crucial, and those with culture-positive sepsis will require close monitoring and follow-up evaluations.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>30648034</pmid><doi>10.7759/cureus.3492</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2018-10, Vol.10 (10), p.e3492-e3492 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6318141 |
| source | PubMed Central; PubMed Central Open Access |
| subjects | Age Birth weight Births Cerebral palsy Cohort analysis Health education Health risk assessment Hemorrhage Low income groups Mortality Neurology Newborn babies Pediatrics Preventive Medicine Sepsis Statistical analysis Ventilators |
| title | Early Neurodevelopmental Outcome of Very Low Birthweight Neonates with Culture-positive Blood Stream Infection: A Prospective Cohort Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T05%3A07%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20Neurodevelopmental%20Outcome%20of%20Very%20Low%20Birthweight%20Neonates%20with%20Culture-positive%20Blood%20Stream%20Infection:%20A%20Prospective%20Cohort%20Study&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Singh,%20Laxman&rft.date=2018-10-24&rft.volume=10&rft.issue=10&rft.spage=e3492&rft.epage=e3492&rft.pages=e3492-e3492&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.3492&rft_dat=%3Cproquest_pubme%3E2174139490%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2174139490&rft_id=info:pmid/30648034&rfr_iscdi=true |