Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation

B7-H3 is a tumor-promoting glycoprotein that is expressed at low levels in most normal tissues, but is overexpressed in various human cancers which is associated with disease progression and poor patient outcome. Although numerous publications have reported the correlation between B7-H3 and cancer p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2019-01, Vol.38 (1), p.88-102
Hauptverfasser:	Liu, Zixing, Zhang, Wenling, Phillips, Joshua B., Arora, Ritu, McClellan, Steven, Li, Jiangfeng, Kim, Jin-Hwan, Sobol, Robert W., Tan, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/95 14/34 42/109 42/89 631/67/1347 631/67/71 96/100 Animals Apoptosis B7 antigen B7 Antigens - antagonists & inhibitors B7 Antigens - chemistry B7 Antigens - genetics B7 Antigens - physiology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Butadienes - pharmacology Butadienes - therapeutic use Cancer Care and treatment Cell Biology Cell Line, Tumor Cell Polarity Cellular control mechanisms Chemotherapy CRISPR-Cas Systems Development and progression Drug resistance Drug Resistance, Neoplasm - physiology Enzyme Activation Female Genetic aspects Health aspects Human Genetics Humans Immunoprecipitation Immunoproteins Immunoregulation Internal Medicine Malignancy MAP kinase MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - physiology Mass spectroscopy Medicine Medicine & Public Health Mice Mice, Nude Mitogen-activated protein kinases Nanog Homeobox Protein - biosynthesis Nanog Homeobox Protein - genetics Neoplasm Invasiveness Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplastic Stem Cells - metabolism Nitriles - pharmacology Nitriles - therapeutic use Nucleoproteins Oncology Oncology, Experimental Protein Domains Protein Interaction Mapping Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - metabolism Raf protein Recombinant Proteins - metabolism RNA Interference RNA, Guide, CRISPR-Cas Systems RNA, Small Interfering - pharmacology Sequence Deletion SOXB1 Transcription Factors - biosynthesis SOXB1 Transcription Factors - genetics Spheroids, Cellular Stem cells Transfection Up-Regulation Vault Ribonucleoprotein Particles - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!