Conophylline suppresses pancreatic cancer desmoplasia and cancer‐promoting cytokines produced by cancer‐associated fibroblasts

Despite recent advances in cancer treatment, pancreatic cancer is a highly malignant tumor type with a dismal prognosis and it is characterized by dense desmoplasia in the cancer tissue. Cancer‐associated fibroblasts (CAF) are responsible for this fibrotic stroma and promote cancer progression. We p...

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Veröffentlicht in:	Cancer science 2019-01, Vol.110 (1), p.334-344
Hauptverfasser:	Ishii, Norihiro, Araki, Kenichiro, Yokobori, Takehiko, Hagiwara, Kei, Gantumur, Dorgormaa, Yamanaka, Takahiro, Handa, Tadashi, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Harimoto, Norifumi, Masamune, Atsushi, Umezawa, Kazuo, Kuwano, Hiroyuki, Shirabe, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic drugs Antitumor agents Cancer therapies Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Cell growth Cell Line Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Chemokines Chemoresistance Chemotherapy Collagen conophylline CXCL12 protein cytokine Cytokines Cytokines - genetics Cytokines - metabolism Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Female fibroblast Fibroblasts Fibrosis Gemcitabine Gene Expression Regulation, Neoplastic - drug effects Humans Invasiveness Laboratories Ligands Malignancy Manufacturers Metastasis Mice, Inbred NOD Mice, SCID microenvironment Monocyte chemoattractant protein 1 Original Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - prevention & control Pancreatic Stellate Cells - drug effects Pancreatic Stellate Cells - metabolism Proteins Radiation therapy stellate cell Stellate cells Stroma Tumor Burden - drug effects Tumor Burden - genetics Tumors Vinca Alkaloids - administration & dosage Xenograft Model Antitumor Assays Xenografts
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