CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells

Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies. In particular, developing resistance to cabazitaxel is a major challenge in patients with docetaxel‐resistant and castration‐resistant prost...

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Veröffentlicht in:	Cancer science 2019-01, Vol.110 (1), p.279-288
Hauptverfasser:	Natsagdorj, Ariunbold, Izumi, Kouji, Hiratsuka, Kaoru, Machioka, Kazuaki, Iwamoto, Hiroaki, Naito, Renato, Makino, Tomoyuki, Kadomoto, Suguru, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Lin, Wen‐Jye, Maolake, Aerken, Mizokami, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Apoptosis Autocrine signalling cabazitaxel Caspase Castration CC chemokine receptors CCL2 CCR2 protein Cell adhesion & migration Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokine CCL2 - pharmacology Chemoresistance DNA microarrays Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - drug effects Humans Immunoglobulins Kinases Male Metastasis Mice, SCID Monocyte chemoattractant protein 1 Original Paclitaxel Poly(ADP-ribose) polymerase Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proteins Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Ribose Software Taxoids - pharmacology Tumor Burden - drug effects Tumor Burden - genetics Tumors Xenograft Model Antitumor Assays - methods
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