DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis

DEP domain containing 1 (DEPDC1) protein is a novel oncoantigen upregulated in multiple types of cancers which present oncogenic activity and high immunogenicity. However, the function and therapeutic potential of DEPDC1 in hepatocellular carcinoma (HCC) remain unclear. In the present study, we show...

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Veröffentlicht in:	Cancer science 2019-01, Vol.110 (1), p.157-165
Hauptverfasser:	Qu, Di, Cui, Feng, Lu, Dan, Yang, Yu, Xu, Yuqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer therapies Carcinogenesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell division Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics DEP domain containing 1 protein DNA methylation Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene set enrichment analysis Genetic engineering GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism HEK293 Cells Hepatocellular carcinoma Humans Immunogenicity Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medical prognosis Metastases Metastasis Mice, Inbred BALB C Mice, Nude Middle Aged Mutation Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Original Patients Prognosis RNA Interference RNAi Therapeutics - methods Survival Analysis Transcription factors Tumors Wnt protein Xenograft Model Antitumor Assays - methods
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