Dishevelled: A masterful conductor of complex Wnt signals
The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic developmen...
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| Veröffentlicht in: | Cellular signalling 2018-07, Vol.47, p.52-64 |
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| creator | Sharma, Monica Castro-Piedras, Isabel Simmons, Glenn E. Pruitt, Kevin |
| description | The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.
•Dishevelled (DVL) proteins function as principal components of Wnt signaling pathway and govern several cellular processes.•DVL integrates and relays complex Wnt signals, yet how it conducts this symphony of activity still remains poorly understood.•This review discusses the function of DVL in the Wnt signaling pathway in normal and aberrant cellular contexts.•Additionally, it highlights novel roles within the nucleus and discusses new binding partners and novel mechanisms of post-translational regulation. |
| doi_str_mv | 10.1016/j.cellsig.2018.03.004 |
| format | Article |
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•Dishevelled (DVL) proteins function as principal components of Wnt signaling pathway and govern several cellular processes.•DVL integrates and relays complex Wnt signals, yet how it conducts this symphony of activity still remains poorly understood.•This review discusses the function of DVL in the Wnt signaling pathway in normal and aberrant cellular contexts.•Additionally, it highlights novel roles within the nucleus and discusses new binding partners and novel mechanisms of post-translational regulation.</description><identifier>ISSN: 0898-6568</identifier><identifier>EISSN: 1873-3913</identifier><identifier>DOI: 10.1016/j.cellsig.2018.03.004</identifier><identifier>PMID: 29559363</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Cancer ; Development ; Disease ; Dishevelled ; Dishevelled Proteins - chemistry ; Dishevelled Proteins - metabolism ; Humans ; Microtubule-Associated Proteins - metabolism ; Neoplasms - metabolism ; Neoplasms - pathology ; Protein Domains ; Protein Processing, Post-Translational ; Wnt ; Wnt Signaling Pathway ; β-catenin</subject><ispartof>Cellular signalling, 2018-07, Vol.47, p.52-64</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-4d926d8cc0fe2301507057e084ce93a6b36e943bd6ca94526e074cfc023ccd003</citedby><cites>FETCH-LOGICAL-c467t-4d926d8cc0fe2301507057e084ce93a6b36e943bd6ca94526e074cfc023ccd003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cellsig.2018.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29559363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Monica</creatorcontrib><creatorcontrib>Castro-Piedras, Isabel</creatorcontrib><creatorcontrib>Simmons, Glenn E.</creatorcontrib><creatorcontrib>Pruitt, Kevin</creatorcontrib><title>Dishevelled: A masterful conductor of complex Wnt signals</title><title>Cellular signalling</title><addtitle>Cell Signal</addtitle><description>The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.
•Dishevelled (DVL) proteins function as principal components of Wnt signaling pathway and govern several cellular processes.•DVL integrates and relays complex Wnt signals, yet how it conducts this symphony of activity still remains poorly understood.•This review discusses the function of DVL in the Wnt signaling pathway in normal and aberrant cellular contexts.•Additionally, it highlights novel roles within the nucleus and discusses new binding partners and novel mechanisms of post-translational regulation.</description><subject>Animals</subject><subject>Cancer</subject><subject>Development</subject><subject>Disease</subject><subject>Dishevelled</subject><subject>Dishevelled Proteins - chemistry</subject><subject>Dishevelled Proteins - metabolism</subject><subject>Humans</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Protein Domains</subject><subject>Protein Processing, Post-Translational</subject><subject>Wnt</subject><subject>Wnt Signaling Pathway</subject><subject>β-catenin</subject><issn>0898-6568</issn><issn>1873-3913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhJ4By5JIwjmPH5gCqyqdUqZdWHK3seNJ6lcSLnazg39fRLhWcOI1G836MHsZec6g4cPVuVyENQ_J3VQ1cVyAqgOYJ23DdilIYLp6yDWijSyWVPmMvUtoBcAmqfs7OaiOlEUpsmPnk0z0dchS598VFMXZpptgvQ4FhcgvOIRahz8u4H-hX8WOai9w5dUN6yZ71edCr0zxnt18-31x-K6-uv36_vLgqsVHtXDbO1MppROipFusHLciWQDdIRnRqKxSZRmydws40slYEbYM9Qi0QHYA4Zx-OuftlO5JDmubYDXYf_djF3zZ03v57mfy9vQsHqwRv22YNeHsKiOHnQmm2o08rvG6isCSb-SmZiWmZpfIoxRhSitQ_1nCwK3a7syfsq01bEDZjz743f__46PrDOQs-HgWUSR08RZvQ04TkfCScrQv-PxUPXCeW3A</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Sharma, Monica</creator><creator>Castro-Piedras, Isabel</creator><creator>Simmons, Glenn E.</creator><creator>Pruitt, Kevin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Dishevelled: A masterful conductor of complex Wnt signals</title><author>Sharma, Monica ; Castro-Piedras, Isabel ; Simmons, Glenn E. ; Pruitt, Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-4d926d8cc0fe2301507057e084ce93a6b36e943bd6ca94526e074cfc023ccd003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Development</topic><topic>Disease</topic><topic>Dishevelled</topic><topic>Dishevelled Proteins - chemistry</topic><topic>Dishevelled Proteins - metabolism</topic><topic>Humans</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Protein Domains</topic><topic>Protein Processing, Post-Translational</topic><topic>Wnt</topic><topic>Wnt Signaling Pathway</topic><topic>β-catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Monica</creatorcontrib><creatorcontrib>Castro-Piedras, Isabel</creatorcontrib><creatorcontrib>Simmons, Glenn E.</creatorcontrib><creatorcontrib>Pruitt, Kevin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Monica</au><au>Castro-Piedras, Isabel</au><au>Simmons, Glenn E.</au><au>Pruitt, Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dishevelled: A masterful conductor of complex Wnt signals</atitle><jtitle>Cellular signalling</jtitle><addtitle>Cell Signal</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>47</volume><spage>52</spage><epage>64</epage><pages>52-64</pages><issn>0898-6568</issn><eissn>1873-3913</eissn><abstract>The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. 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•Dishevelled (DVL) proteins function as principal components of Wnt signaling pathway and govern several cellular processes.•DVL integrates and relays complex Wnt signals, yet how it conducts this symphony of activity still remains poorly understood.•This review discusses the function of DVL in the Wnt signaling pathway in normal and aberrant cellular contexts.•Additionally, it highlights novel roles within the nucleus and discusses new binding partners and novel mechanisms of post-translational regulation.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>29559363</pmid><doi>10.1016/j.cellsig.2018.03.004</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cancer Development Disease Dishevelled Dishevelled Proteins - chemistry Dishevelled Proteins - metabolism Humans Microtubule-Associated Proteins - metabolism Neoplasms - metabolism Neoplasms - pathology Protein Domains Protein Processing, Post-Translational Wnt Wnt Signaling Pathway β-catenin |
| title | Dishevelled: A masterful conductor of complex Wnt signals |
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