GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing

Mutations in human GRXCR2, which encodes a protein of undetermined function, cause hearing loss by unknown mechanisms. We found that mouse GRXCR2 localizes to the base of the stereocilia, which are actin-based mechanosensing organelles in cochlear hair cells that convert sound-induced vibrations int...

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Veröffentlicht in:	Cell reports (Cambridge) 2018-10, Vol.25 (5), p.1268-1280.e4
Hauptverfasser:	Liu, Chang, Luo, Na, Tung, Chun-Yu, Perrin, Benjamin J, Zhao, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Animals Chlorocebus aethiops COS Cells Deafness - metabolism Deafness - pathology Deafness - physiopathology Evoked Potentials, Auditory, Brain Stem Glutaredoxins - deficiency Glutaredoxins - metabolism Hair Cells, Auditory - metabolism Hair Cells, Auditory - ultrastructure Hearing HEK293 Cells Humans Mice, Inbred C57BL Protein Binding Proteins - metabolism Stereocilia - metabolism Stereocilia - ultrastructure
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