The structure and activity of the glutathione reductase from Streptococcus pneumoniae

The glutathione reductase (GR) from Streptococcus pneumoniae is a flavoenzyme that catalyzes the reduction of oxidized glutathione (GSSG) to its reduced form (GSH) in the cytoplasm of this bacterium. The maintenance of an intracellular pool of GSH is critical for the detoxification of reactive oxyge...

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Veröffentlicht in:	Acta crystallographica. Section F, Structural biology communications Structural biology communications, 2019-01, Vol.75 (1), p.54-61
Hauptverfasser:	Sikanyika, Mwilye, Aragão, David, McDevitt, Christopher A., Maher, Megan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Biocatalysis Cloning, Molecular Crystal structure Crystallography, X-Ray Cytoplasm Detoxification Dimers Enzymes Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Glutathione Glutathione - chemistry Glutathione - metabolism Glutathione reductase Glutathione Reductase - chemistry Glutathione Reductase - genetics Glutathione Reductase - metabolism Intracellular Kinetics Models, Molecular Molecular structure NADP - chemistry NADP - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Reactive nitrogen species Reactive oxygen species Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Research Communications Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - chemistry Streptococcus pneumoniae - enzymology Structural Homology, Protein Substrate Specificity X‐ray crystallography Zinc
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