Health Effects of Resveratrol: Results from Human Intervention Trials
The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and...
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| Veröffentlicht in: | Nutrients 2018-12, Vol.10 (12), p.1892 |
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| creator | Ramírez-Garza, Sonia L Laveriano-Santos, Emily P Marhuenda-Muñoz, María Storniolo, Carolina E Tresserra-Rimbau, Anna Vallverdú-Queralt, Anna Lamuela-Raventós, Rosa M |
| description | The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. Much of the research on RV in the last 10 years has focused on its effects on pathologies related to oxidative stress, inflammatory biomarkers, T2D, cardiovascular diseases, and neurological diseases. |
| doi_str_mv | 10.3390/nu10121892 |
| format | Article |
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The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. Much of the research on RV in the last 10 years has focused on its effects on pathologies related to oxidative stress, inflammatory biomarkers, T2D, cardiovascular diseases, and neurological diseases.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10121892</identifier><identifier>PMID: 30513922</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bioavailability ; Biological properties ; Biological samples ; biomarkers ; Blood plasma ; Cardiovascular diseases ; Chronic illnesses ; Clinical trials ; cognition ; Diabetes mellitus (non-insulin dependent) ; Enzymes ; feces ; Food ; Food matrix ; health effects assessments ; health status ; inflammation ; Ingestion ; Kinases ; Metabolism ; Metabolites ; Microbiota ; neoplasms ; nervous system diseases ; Neurological diseases ; noninsulin-dependent diabetes mellitus ; nutritional intervention ; Oxidative stress ; Particle size ; Pharmacokinetics ; Plasma ; Polyphenols ; Proteins ; Resveratrol ; Review ; Urine</subject><ispartof>Nutrients, 2018-12, Vol.10 (12), p.1892</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. 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The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. 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| subjects | Bioavailability Biological properties Biological samples biomarkers Blood plasma Cardiovascular diseases Chronic illnesses Clinical trials cognition Diabetes mellitus (non-insulin dependent) Enzymes feces Food Food matrix health effects assessments health status inflammation Ingestion Kinases Metabolism Metabolites Microbiota neoplasms nervous system diseases Neurological diseases noninsulin-dependent diabetes mellitus nutritional intervention Oxidative stress Particle size Pharmacokinetics Plasma Polyphenols Proteins Resveratrol Review Urine |
| title | Health Effects of Resveratrol: Results from Human Intervention Trials |
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