Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma
Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver...
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| Veröffentlicht in: | Nutrients 2018-12, Vol.10 (12), p.1955 |
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| creator | Hosui, Atsushi Kimura, Eiji Abe, Sumiko Tanimoto, Takashi Onishi, Kousaku Kusumoto, Yukihiro Sueyoshi, Yuka Matsumoto, Kengo Hirao, Motohiro Yamada, Takuya Hiramatsu, Naoki |
| description | Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development remains unknown. Two hundred and sixty-seven patients with CLDs who received a zinc preparation (Zn-group; 196 patients), or who did not receive zinc (no Zn-treatment group; 71 patients), were retrospectively analyzed in this study. The Zn-group was divided into 4 groups according to their serum Zn concentrations at 6 months after the start of Zn treatment. Liver function significantly deteriorated in the no Zn-treatment group, while no notable change was observed in the Zn-group. The cumulative incidence rates of events and HCC at 3 years were observed to be lower in the Zn-group (9.5%, 7.6%) than in the no Zn-treatment group (24.9%, 19.2%) (
< 0.001). According to serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations ≥ 70 µg/dL (
< 0.001). Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 µg/dL. |
| doi_str_mv | 10.3390/nu10121955 |
| format | Article |
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< 0.001). According to serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations ≥ 70 µg/dL (
< 0.001). Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 µg/dL.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10121955</identifier><identifier>PMID: 30544767</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine ; Aged ; Aged, 80 and over ; blood serum ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - prevention & control ; dietary mineral supplements ; Dietary Supplements ; Diuretics ; Enzymes ; Female ; Fibrosis ; Hepatocellular carcinoma ; hepatoma ; Humans ; Incidence ; Investigations ; Liver ; Liver - drug effects ; Liver cancer ; liver cirrhosis ; Liver diseases ; liver function ; Liver Neoplasms - drug therapy ; Liver Neoplasms - epidemiology ; Liver Neoplasms - mortality ; Liver Neoplasms - prevention & control ; Male ; Middle Aged ; Patients ; Retrospective Studies ; risk reduction ; Zinc ; Zinc - administration & dosage ; Zinc - blood ; Zinc - pharmacology ; Zinc - therapeutic use</subject><ispartof>Nutrients, 2018-12, Vol.10 (12), p.1955</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-5222ee51613a9745dad04f65ab4618d08bfdd90f41b31cde1324fa5372cc17153</citedby><cites>FETCH-LOGICAL-c505t-5222ee51613a9745dad04f65ab4618d08bfdd90f41b31cde1324fa5372cc17153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316561/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316561/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30544767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosui, Atsushi</creatorcontrib><creatorcontrib>Kimura, Eiji</creatorcontrib><creatorcontrib>Abe, Sumiko</creatorcontrib><creatorcontrib>Tanimoto, Takashi</creatorcontrib><creatorcontrib>Onishi, Kousaku</creatorcontrib><creatorcontrib>Kusumoto, Yukihiro</creatorcontrib><creatorcontrib>Sueyoshi, Yuka</creatorcontrib><creatorcontrib>Matsumoto, Kengo</creatorcontrib><creatorcontrib>Hirao, Motohiro</creatorcontrib><creatorcontrib>Yamada, Takuya</creatorcontrib><creatorcontrib>Hiramatsu, Naoki</creatorcontrib><title>Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development remains unknown. Two hundred and sixty-seven patients with CLDs who received a zinc preparation (Zn-group; 196 patients), or who did not receive zinc (no Zn-treatment group; 71 patients), were retrospectively analyzed in this study. The Zn-group was divided into 4 groups according to their serum Zn concentrations at 6 months after the start of Zn treatment. Liver function significantly deteriorated in the no Zn-treatment group, while no notable change was observed in the Zn-group. The cumulative incidence rates of events and HCC at 3 years were observed to be lower in the Zn-group (9.5%, 7.6%) than in the no Zn-treatment group (24.9%, 19.2%) (
< 0.001). According to serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations ≥ 70 µg/dL (
< 0.001). Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 µg/dL.</description><subject>Adenosine</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>blood serum</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - prevention & control</subject><subject>dietary mineral supplements</subject><subject>Dietary Supplements</subject><subject>Diuretics</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hepatocellular carcinoma</subject><subject>hepatoma</subject><subject>Humans</subject><subject>Incidence</subject><subject>Investigations</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver cancer</subject><subject>liver cirrhosis</subject><subject>Liver diseases</subject><subject>liver function</subject><subject>Liver Neoplasms - 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drug therapy</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - prevention & control</topic><topic>dietary mineral supplements</topic><topic>Dietary Supplements</topic><topic>Diuretics</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hepatocellular carcinoma</topic><topic>hepatoma</topic><topic>Humans</topic><topic>Incidence</topic><topic>Investigations</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver cancer</topic><topic>liver cirrhosis</topic><topic>Liver diseases</topic><topic>liver function</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - prevention & control</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>risk reduction</topic><topic>Zinc</topic><topic>Zinc - 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Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development remains unknown. Two hundred and sixty-seven patients with CLDs who received a zinc preparation (Zn-group; 196 patients), or who did not receive zinc (no Zn-treatment group; 71 patients), were retrospectively analyzed in this study. The Zn-group was divided into 4 groups according to their serum Zn concentrations at 6 months after the start of Zn treatment. Liver function significantly deteriorated in the no Zn-treatment group, while no notable change was observed in the Zn-group. The cumulative incidence rates of events and HCC at 3 years were observed to be lower in the Zn-group (9.5%, 7.6%) than in the no Zn-treatment group (24.9%, 19.2%) (
< 0.001). According to serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations ≥ 70 µg/dL (
< 0.001). Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 µg/dL.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30544767</pmid><doi>10.3390/nu10121955</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Aged Aged, 80 and over blood serum Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - prevention & control dietary mineral supplements Dietary Supplements Diuretics Enzymes Female Fibrosis Hepatocellular carcinoma hepatoma Humans Incidence Investigations Liver Liver - drug effects Liver cancer liver cirrhosis Liver diseases liver function Liver Neoplasms - drug therapy Liver Neoplasms - epidemiology Liver Neoplasms - mortality Liver Neoplasms - prevention & control Male Middle Aged Patients Retrospective Studies risk reduction Zinc Zinc - administration & dosage Zinc - blood Zinc - pharmacology Zinc - therapeutic use |
| title | Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma |
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