Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue
Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The...
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| Veröffentlicht in: | Nutrients 2018-12, Vol.10 (12), p.1962 |
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| creator | Akindehin, Seun Jung, Young-Suk Kim, Sang-Nam Son, Yeon-Ho Lee, Icksoo Seong, Je Kyung Jeong, Hyun Woo Lee, Yun-Hee |
| description | Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue. |
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This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10121962</identifier><identifier>PMID: 30545041</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetylation ; Adipocytes ; Adipocytes - drug effects ; Adipocytes - metabolism ; Adipose tissue ; Animals ; Anti-Obesity Agents - pharmacology ; Biological activity ; Blood Glucose - drug effects ; Body fat ; Body weight ; Body Weight - drug effects ; Cell Line ; Diet ; Diet, High-Fat ; Energy ; Fatty acids ; Flavonoids - pharmacology ; Gene expression ; genes ; Glucose ; Glucose tolerance ; High fat diet ; Insulin ; Kinases ; Laboratory animals ; Lipids ; Lipolysis ; Male ; Mammals ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - metabolism ; myricetin ; Obesity ; Oxygen consumption ; polyphenols ; Proteins ; Respiration ; Sirtuin 3 - analysis ; Sirtuin 3 - genetics ; Sirtuin 3 - metabolism ; Statistical analysis ; triacylglycerols ; Triglycerides ; Up-Regulation - drug effects ; Variance analysis ; Weight reduction</subject><ispartof>Nutrients, 2018-12, Vol.10 (12), p.1962</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-a86c418cf996adce76472cb6af0af2c5de9462aeb3f89c6f1c8faf49022d932b3</citedby><cites>FETCH-LOGICAL-c505t-a86c418cf996adce76472cb6af0af2c5de9462aeb3f89c6f1c8faf49022d932b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30545041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akindehin, Seun</creatorcontrib><creatorcontrib>Jung, Young-Suk</creatorcontrib><creatorcontrib>Kim, Sang-Nam</creatorcontrib><creatorcontrib>Son, Yeon-Ho</creatorcontrib><creatorcontrib>Lee, Icksoo</creatorcontrib><creatorcontrib>Seong, Je Kyung</creatorcontrib><creatorcontrib>Jeong, Hyun Woo</creatorcontrib><creatorcontrib>Lee, Yun-Hee</creatorcontrib><title>Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue.</description><subject>Acetylation</subject><subject>Adipocytes</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adipose tissue</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Biological activity</subject><subject>Blood Glucose - drug effects</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Body Weight - drug effects</subject><subject>Cell Line</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Energy</subject><subject>Fatty acids</subject><subject>Flavonoids - pharmacology</subject><subject>Gene expression</subject><subject>genes</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>High fat diet</subject><subject>Insulin</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lipids</subject><subject>Lipolysis</subject><subject>Male</subject><subject>Mammals</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>myricetin</subject><subject>Obesity</subject><subject>Oxygen consumption</subject><subject>polyphenols</subject><subject>Proteins</subject><subject>Respiration</subject><subject>Sirtuin 3 - analysis</subject><subject>Sirtuin 3 - genetics</subject><subject>Sirtuin 3 - metabolism</subject><subject>Statistical analysis</subject><subject>triacylglycerols</subject><subject>Triglycerides</subject><subject>Up-Regulation - drug effects</subject><subject>Variance analysis</subject><subject>Weight reduction</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkU1LAzEQhoMoKurFHyALXkRYzdfObi5CKfUDFEHbc8imSRvZbmqSFfvv3eK3F3OZkHnmzcy8CB0SfMaYwOdtRzChRADdQLsUlzQH4Gzzx30HHcT4hNenxCWwbbTDcMELzMkumtytgtMmuTYbvZqQYjZok8vvaxNdWmUja43uH9M8-G42zybLYGZdo5LzbeZt9njzMGZZXzyYuqWPJhu7GDuzj7asaqI5-Ih7aHI5Gg-v89v7q5vh4DbXBS5SrirQnFTaCgFqqk0JvKS6BmWxslQXUyM4UGVqZiuhwRJdWWW5wJROBaM120MX77rLrl6YXqFNQTVyGdxChZX0ysnfmdbN5cy_SGAEGCe9wMmHQPDPnYlJLlzUpmlUa3wXJaUVCAyYVf-jpCih5CVZo8d_0CffhbbfhKQAvQW0wOu_T98pHXyMwdivvgmWa2_lt7c9fPRz0i_000n2BiSCns0</recordid><startdate>20181212</startdate><enddate>20181212</enddate><creator>Akindehin, Seun</creator><creator>Jung, Young-Suk</creator><creator>Kim, Sang-Nam</creator><creator>Son, Yeon-Ho</creator><creator>Lee, Icksoo</creator><creator>Seong, Je Kyung</creator><creator>Jeong, Hyun Woo</creator><creator>Lee, Yun-Hee</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20181212</creationdate><title>Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue</title><author>Akindehin, Seun ; 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This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30545041</pmid><doi>10.3390/nu10121962</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylation Adipocytes Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Animals Anti-Obesity Agents - pharmacology Biological activity Blood Glucose - drug effects Body fat Body weight Body Weight - drug effects Cell Line Diet Diet, High-Fat Energy Fatty acids Flavonoids - pharmacology Gene expression genes Glucose Glucose tolerance High fat diet Insulin Kinases Laboratory animals Lipids Lipolysis Male Mammals Metabolism Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - metabolism myricetin Obesity Oxygen consumption polyphenols Proteins Respiration Sirtuin 3 - analysis Sirtuin 3 - genetics Sirtuin 3 - metabolism Statistical analysis triacylglycerols Triglycerides Up-Regulation - drug effects Variance analysis Weight reduction |
| title | Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue |
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