Readily Accessible Ambiphilic Cyclopentadienes for Bioorthogonal Labeling

A new class of bioorthogonal reagents based on the cyclopentadiene scaffold is described. The diene 6,7,8,9-tetrachloro-1,4-dioxo­spiro­[4,4]­nona-6,8-diene (a tetrachlorocyclopentadiene ketal, TCK) is ambiphilic and self-orthogonal with remarkable stability. The diene reacts rapidly with a trans-cy...

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Veröffentlicht in:	Journal of the American Chemical Society 2018-05, Vol.140 (20), p.6426-6431
Hauptverfasser:	Levandowski, Brian J, Gamache, Raymond F, Murphy, Jennifer M, Houk, K. N
Format:	Artikel
Sprache:	eng
Schlagworte:	azides Azides - chemistry Chemistry Techniques, Synthetic Cyclooctanes - chemistry Cyclopentanes - chemical synthesis Cyclopentanes - chemistry Halogenation Indicators and Reagents labeling techniques Staining and Labeling
Online-Zugang:	Volltext
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