Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines: A retrospective study
This study sought to assess the malignant risks of "unspecified" thyroid nodules; that is, nodules that were not of a type described in the 2015 American Thyroid Association (ATA) guidelines.We retrospectively reviewed medical records and ultrasound (US) data for 1808 consecutive patients...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-12, Vol.97 (52), p.e13914-e13914 |
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| creator | Gao, Luying Xi, Xuehua Wang, Juanjuan Yang, Xiao Wang, Ying Zhu, Shenling Lai, Xingjian Zhang, Xiaoyan Zhao, Ruina Zhang, Bo |
| description | This study sought to assess the malignant risks of "unspecified" thyroid nodules; that is, nodules that were not of a type described in the 2015 American Thyroid Association (ATA) guidelines.We retrospectively reviewed medical records and ultrasound (US) data for 1808 consecutive patients with 2614 thyroid nodules who underwent thyroidectomy between January 2015 and December 2015. Nodules with US features that did not satisfy the criteria for any risk category in the 2015 ATA guidelines were defined as "unspecified" nodules. These thyroid nodules were retrospectively assessed using the Thyroid Imaging, Reporting and Data System proposed by Kwak (Kwak-TIRADS) and the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR-TIRADS).There were 70 "unspecified" nodules (2.7%, 70/2614), and 18.6% (13/70) of these nodules were malignant. The percentages of nodules with Kwak-TIRADS grades 4a, 4b and 4c were 53.3%, 40.0%, and 6.7%, respectively. The percentages of nodules with ACR-TIRADS grades TR2, TR3, TR4, and TR5 were 5.7%, 2.9%, 70.0%, and 21.4%, respectively. Among the "unspecified" nodules, there were significantly more nodules in Kwak-TIRADS categories 4b and 4c in the malignant pathology group than in the benign pathology group (P |
| doi_str_mv | 10.1097/MD.0000000000013914 |
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Nodules with US features that did not satisfy the criteria for any risk category in the 2015 ATA guidelines were defined as "unspecified" nodules. These thyroid nodules were retrospectively assessed using the Thyroid Imaging, Reporting and Data System proposed by Kwak (Kwak-TIRADS) and the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR-TIRADS).There were 70 "unspecified" nodules (2.7%, 70/2614), and 18.6% (13/70) of these nodules were malignant. The percentages of nodules with Kwak-TIRADS grades 4a, 4b and 4c were 53.3%, 40.0%, and 6.7%, respectively. The percentages of nodules with ACR-TIRADS grades TR2, TR3, TR4, and TR5 were 5.7%, 2.9%, 70.0%, and 21.4%, respectively. Among the "unspecified" nodules, there were significantly more nodules in Kwak-TIRADS categories 4b and 4c in the malignant pathology group than in the benign pathology group (P <.01).Our results imply that "unspecified" thyroid nodules based on the ATA guidelines could partly be evaluated using the Kwak-TIRADS and that the ATA guidelines could incorporate more accurate malignant risk stratification.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000013914</identifier><identifier>PMID: 30593211</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adult ; Aged ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Observational Study ; Practice Guidelines as Topic ; Retrospective Studies ; Risk Assessment ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - pathology ; Thyroid Nodule - diagnosis ; Thyroid Nodule - diagnostic imaging ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery ; Thyroidectomy - statistics & numerical data ; Ultrasonography ; United States</subject><ispartof>Medicine (Baltimore), 2018-12, Vol.97 (52), p.e13914-e13914</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3557-a28eeea7d320c331acfcd785acd116fe92f6c4cad844e81a091a5428d43fbac53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314728/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30593211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Luying</creatorcontrib><creatorcontrib>Xi, Xuehua</creatorcontrib><creatorcontrib>Wang, Juanjuan</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhu, Shenling</creatorcontrib><creatorcontrib>Lai, Xingjian</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Zhao, Ruina</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><title>Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines: A retrospective study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>This study sought to assess the malignant risks of "unspecified" thyroid nodules; that is, nodules that were not of a type described in the 2015 American Thyroid Association (ATA) guidelines.We retrospectively reviewed medical records and ultrasound (US) data for 1808 consecutive patients with 2614 thyroid nodules who underwent thyroidectomy between January 2015 and December 2015. Nodules with US features that did not satisfy the criteria for any risk category in the 2015 ATA guidelines were defined as "unspecified" nodules. These thyroid nodules were retrospectively assessed using the Thyroid Imaging, Reporting and Data System proposed by Kwak (Kwak-TIRADS) and the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR-TIRADS).There were 70 "unspecified" nodules (2.7%, 70/2614), and 18.6% (13/70) of these nodules were malignant. The percentages of nodules with Kwak-TIRADS grades 4a, 4b and 4c were 53.3%, 40.0%, and 6.7%, respectively. The percentages of nodules with ACR-TIRADS grades TR2, TR3, TR4, and TR5 were 5.7%, 2.9%, 70.0%, and 21.4%, respectively. Among the "unspecified" nodules, there were significantly more nodules in Kwak-TIRADS categories 4b and 4c in the malignant pathology group than in the benign pathology group (P <.01).Our results imply that "unspecified" thyroid nodules based on the ATA guidelines could partly be evaluated using the Kwak-TIRADS and that the ATA guidelines could incorporate more accurate malignant risk stratification.</description><subject>Adult</subject><subject>Aged</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Practice Guidelines as Topic</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Nodule - diagnosis</subject><subject>Thyroid Nodule - diagnostic imaging</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><subject>Thyroidectomy - statistics & numerical data</subject><subject>Ultrasonography</subject><subject>United States</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctuEzEUhkcIRNPCEyAhL9lM8XU8wwIp6gWQWrFp15Zrn0lMPXawPamy64MAD9cnYUJCuXhzZJ___3yO_qp6RfAxwZ18e3l6jP8cwjrCn1QzIlhTi67hT6sZxlTUspP8oDrM-ctWJCl_Xh0wLDpGCZlVP659STrHMViUXL5FsNZ-1MXFgGKPynKTorMoRDt6yNNdF6QToIf7b2PIKzCud2Af7r8jF6YuIIqJQPMBkjM6oKu9f55zNG6HHXTQCxggFLQYnQXvAuR3aI4SlBS3zOLWgHIZ7eZF9azXPsPLfT2qrs_Prk4-1hefP3w6mV_Uhgkha01bANDSMooNY0Sb3ljZCm0sIU0PHe0bw422LefQEo07ogWnreWsv9FGsKPq_Y67Gm8GsGYaLmmvVskNOm1U1E792wluqRZxrRpGuKTtBHizB6T4dYRc1OCyAe91gDhmRUlDJKa4oZOU7aRm2jYn6B-_IVhtk1WXp-r_ZCfX678nfPT8jnIS8J3gLvoCKd_68Q6SWoL2ZfmLJ2RH6ymfllDa4np6aSX7CXRytQY</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Gao, Luying</creator><creator>Xi, Xuehua</creator><creator>Wang, Juanjuan</creator><creator>Yang, Xiao</creator><creator>Wang, Ying</creator><creator>Zhu, Shenling</creator><creator>Lai, Xingjian</creator><creator>Zhang, Xiaoyan</creator><creator>Zhao, Ruina</creator><creator>Zhang, Bo</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines: A retrospective study</title><author>Gao, Luying ; Xi, Xuehua ; Wang, Juanjuan ; Yang, Xiao ; Wang, Ying ; Zhu, Shenling ; Lai, Xingjian ; Zhang, Xiaoyan ; Zhao, Ruina ; Zhang, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3557-a28eeea7d320c331acfcd785acd116fe92f6c4cad844e81a091a5428d43fbac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Practice Guidelines as Topic</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Nodule - diagnosis</topic><topic>Thyroid Nodule - diagnostic imaging</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><topic>Thyroidectomy - statistics & numerical data</topic><topic>Ultrasonography</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Luying</creatorcontrib><creatorcontrib>Xi, Xuehua</creatorcontrib><creatorcontrib>Wang, Juanjuan</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhu, Shenling</creatorcontrib><creatorcontrib>Lai, Xingjian</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Zhao, Ruina</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Luying</au><au>Xi, Xuehua</au><au>Wang, Juanjuan</au><au>Yang, Xiao</au><au>Wang, Ying</au><au>Zhu, Shenling</au><au>Lai, Xingjian</au><au>Zhang, Xiaoyan</au><au>Zhao, Ruina</au><au>Zhang, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines: A retrospective study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>97</volume><issue>52</issue><spage>e13914</spage><epage>e13914</epage><pages>e13914-e13914</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>This study sought to assess the malignant risks of "unspecified" thyroid nodules; that is, nodules that were not of a type described in the 2015 American Thyroid Association (ATA) guidelines.We retrospectively reviewed medical records and ultrasound (US) data for 1808 consecutive patients with 2614 thyroid nodules who underwent thyroidectomy between January 2015 and December 2015. Nodules with US features that did not satisfy the criteria for any risk category in the 2015 ATA guidelines were defined as "unspecified" nodules. These thyroid nodules were retrospectively assessed using the Thyroid Imaging, Reporting and Data System proposed by Kwak (Kwak-TIRADS) and the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR-TIRADS).There were 70 "unspecified" nodules (2.7%, 70/2614), and 18.6% (13/70) of these nodules were malignant. The percentages of nodules with Kwak-TIRADS grades 4a, 4b and 4c were 53.3%, 40.0%, and 6.7%, respectively. The percentages of nodules with ACR-TIRADS grades TR2, TR3, TR4, and TR5 were 5.7%, 2.9%, 70.0%, and 21.4%, respectively. Among the "unspecified" nodules, there were significantly more nodules in Kwak-TIRADS categories 4b and 4c in the malignant pathology group than in the benign pathology group (P <.01).Our results imply that "unspecified" thyroid nodules based on the ATA guidelines could partly be evaluated using the Kwak-TIRADS and that the ATA guidelines could incorporate more accurate malignant risk stratification.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30593211</pmid><doi>10.1097/MD.0000000000013914</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Diagnosis, Differential Female Humans Male Middle Aged Observational Study Practice Guidelines as Topic Retrospective Studies Risk Assessment Thyroid Neoplasms - diagnosis Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - pathology Thyroid Nodule - diagnosis Thyroid Nodule - diagnostic imaging Thyroid Nodule - pathology Thyroid Nodule - surgery Thyroidectomy - statistics & numerical data Ultrasonography United States |
| title | Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines: A retrospective study |
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