Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma
This study aimed to compare the sensitivity and accuracy for the detection of small lesions in patients with hepatocellular carcinoma (HCC) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 64-slice comp...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-12, Vol.97 (52), p.e13964-e13964 |
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| container_title | Medicine (Baltimore) |
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| creator | Li, Jiangfa Li, Xiaoqing Weng, Jun Lei, Liping Gong, Jianhua Wang, Junyi Li, Zhenghang Zhang, Longmiao He, Songqing |
| description | This study aimed to compare the sensitivity and accuracy for the detection of small lesions in patients with hepatocellular carcinoma (HCC) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 64-slice computed tomography (CT) enhanced scanning, and to evaluate the necessity to perform MRI in patients diagnosed with HCC by CT.The clinical data from 209 patients with HCC diagnosed prior to surgery in the Affiliated Hospital of Guilin Medical University, China were retrospectively analyzed. The 64-slice dynamic contrast-enhanced multi-detector CT (MDCT) and 3.0 T Gd-EOB-DTPA DCE MRI procedures were successively carried out on all patients who were enrolled in a self-controlled study including detection and diagnosis of HCC lesions by MRI and CT, respectively.A total of 243 lesions were detected and both imaging methods could accurately detect lesions of diameter >2 cm. For lesions |
| doi_str_mv | 10.1097/MD.0000000000013964 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6314721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2161699109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4505-d04d9f979ff120fd72306c0ecf8344fbb6002edbe28c6f3b60b259ad5ce35d063</originalsourceid><addsrcrecordid>eNpdUctuEzEUHSEQDYUvQEJesnHrx3gm3iCVpBSkVmUR1iPHc50xeOxgO436af07PKQND2_sc-85x_Y9VfWWkjNKZHt-szwjfxblsqmfVTMqeINFOT-vZoQwgVvZ1ifVq5S-T6SW1S-rE06E5IzKWfVw1ePL2494ufp6gfp7r0arkQ4-R5UyBj8or6FHo9p4yKUVIQU_1ZAtNes3yCY0hggIjAGd7R2gXEToKG1qnJwtgsUKmRBLF1APeeIGj4JBaVTOIQep4ISsR1uVLfic0N7mAQ1QcNDg3M6piLSK2vowqtfVC6NcgjeP-2n17dPlavEZX99efVlcXGNdCyJwT-peGtlKYygjpm8ZJ40moM2c17VZr5syJejXwOa6MbzANRNS9UIDFz1p-Gn14eC73a1H6DVMs3HdNpYBxPsuKNv92_F26Dbhrms4rVtGi8H7R4MYfu4g5W60afqP8hB2qWO0oY2UJdNC5QeqjiGlCOZ4DSXdFHp3s-z-D72o3v39wqPmKeVCqA-EfXAZYvrhdnuI3QDK5eG3n2glw4zQOWVsTnCpSMF_AT7Pu5E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2161699109</pqid></control><display><type>article</type><title>Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Jiangfa ; Li, Xiaoqing ; Weng, Jun ; Lei, Liping ; Gong, Jianhua ; Wang, Junyi ; Li, Zhenghang ; Zhang, Longmiao ; He, Songqing</creator><creatorcontrib>Li, Jiangfa ; Li, Xiaoqing ; Weng, Jun ; Lei, Liping ; Gong, Jianhua ; Wang, Junyi ; Li, Zhenghang ; Zhang, Longmiao ; He, Songqing</creatorcontrib><description>This study aimed to compare the sensitivity and accuracy for the detection of small lesions in patients with hepatocellular carcinoma (HCC) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 64-slice computed tomography (CT) enhanced scanning, and to evaluate the necessity to perform MRI in patients diagnosed with HCC by CT.The clinical data from 209 patients with HCC diagnosed prior to surgery in the Affiliated Hospital of Guilin Medical University, China were retrospectively analyzed. The 64-slice dynamic contrast-enhanced multi-detector CT (MDCT) and 3.0 T Gd-EOB-DTPA DCE MRI procedures were successively carried out on all patients who were enrolled in a self-controlled study including detection and diagnosis of HCC lesions by MRI and CT, respectively.A total of 243 lesions were detected and both imaging methods could accurately detect lesions of diameter >2 cm. For lesions <2 cm, MRI detected 47, while CT detected 25 lesions indicating that the detection rate of MRI was 88% higher than that of CT. In addition, MRI detected lesions in 15 cases (7.81% in the total of 209 cases) that were not diagnosed by CT. Among these cases, 2 patients were diagnosed to have no lesion by CT.Gd-EOB-DTPA DCE-MRI performed as a routine check prior to surgery in HCC patients can improve the detection of small HCC lesions.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000013964</identifier><identifier>PMID: 30593219</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; China ; Contrast Media ; Female ; Gadolinium DTPA - administration & dosage ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Observational Study ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, Spiral Computed - methods</subject><ispartof>Medicine (Baltimore), 2018-12, Vol.97 (52), p.e13964-e13964</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4505-d04d9f979ff120fd72306c0ecf8344fbb6002edbe28c6f3b60b259ad5ce35d063</citedby><cites>FETCH-LOGICAL-c4505-d04d9f979ff120fd72306c0ecf8344fbb6002edbe28c6f3b60b259ad5ce35d063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314721/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314721/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30593219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jiangfa</creatorcontrib><creatorcontrib>Li, Xiaoqing</creatorcontrib><creatorcontrib>Weng, Jun</creatorcontrib><creatorcontrib>Lei, Liping</creatorcontrib><creatorcontrib>Gong, Jianhua</creatorcontrib><creatorcontrib>Wang, Junyi</creatorcontrib><creatorcontrib>Li, Zhenghang</creatorcontrib><creatorcontrib>Zhang, Longmiao</creatorcontrib><creatorcontrib>He, Songqing</creatorcontrib><title>Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>This study aimed to compare the sensitivity and accuracy for the detection of small lesions in patients with hepatocellular carcinoma (HCC) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 64-slice computed tomography (CT) enhanced scanning, and to evaluate the necessity to perform MRI in patients diagnosed with HCC by CT.The clinical data from 209 patients with HCC diagnosed prior to surgery in the Affiliated Hospital of Guilin Medical University, China were retrospectively analyzed. The 64-slice dynamic contrast-enhanced multi-detector CT (MDCT) and 3.0 T Gd-EOB-DTPA DCE MRI procedures were successively carried out on all patients who were enrolled in a self-controlled study including detection and diagnosis of HCC lesions by MRI and CT, respectively.A total of 243 lesions were detected and both imaging methods could accurately detect lesions of diameter >2 cm. For lesions <2 cm, MRI detected 47, while CT detected 25 lesions indicating that the detection rate of MRI was 88% higher than that of CT. In addition, MRI detected lesions in 15 cases (7.81% in the total of 209 cases) that were not diagnosed by CT. Among these cases, 2 patients were diagnosed to have no lesion by CT.Gd-EOB-DTPA DCE-MRI performed as a routine check prior to surgery in HCC patients can improve the detection of small HCC lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>China</subject><subject>Contrast Media</subject><subject>Female</subject><subject>Gadolinium DTPA - administration & dosage</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Spiral Computed - methods</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctuEzEUHSEQDYUvQEJesnHrx3gm3iCVpBSkVmUR1iPHc50xeOxgO436af07PKQND2_sc-85x_Y9VfWWkjNKZHt-szwjfxblsqmfVTMqeINFOT-vZoQwgVvZ1ifVq5S-T6SW1S-rE06E5IzKWfVw1ePL2494ufp6gfp7r0arkQ4-R5UyBj8or6FHo9p4yKUVIQU_1ZAtNes3yCY0hggIjAGd7R2gXEToKG1qnJwtgsUKmRBLF1APeeIGj4JBaVTOIQep4ISsR1uVLfic0N7mAQ1QcNDg3M6piLSK2vowqtfVC6NcgjeP-2n17dPlavEZX99efVlcXGNdCyJwT-peGtlKYygjpm8ZJ40moM2c17VZr5syJejXwOa6MbzANRNS9UIDFz1p-Gn14eC73a1H6DVMs3HdNpYBxPsuKNv92_F26Dbhrms4rVtGi8H7R4MYfu4g5W60afqP8hB2qWO0oY2UJdNC5QeqjiGlCOZ4DSXdFHp3s-z-D72o3v39wqPmKeVCqA-EfXAZYvrhdnuI3QDK5eG3n2glw4zQOWVsTnCpSMF_AT7Pu5E</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Li, Jiangfa</creator><creator>Li, Xiaoqing</creator><creator>Weng, Jun</creator><creator>Lei, Liping</creator><creator>Gong, Jianhua</creator><creator>Wang, Junyi</creator><creator>Li, Zhenghang</creator><creator>Zhang, Longmiao</creator><creator>He, Songqing</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma</title><author>Li, Jiangfa ; Li, Xiaoqing ; Weng, Jun ; Lei, Liping ; Gong, Jianhua ; Wang, Junyi ; Li, Zhenghang ; Zhang, Longmiao ; He, Songqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4505-d04d9f979ff120fd72306c0ecf8344fbb6002edbe28c6f3b60b259ad5ce35d063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>China</topic><topic>Contrast Media</topic><topic>Female</topic><topic>Gadolinium DTPA - administration & dosage</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, Spiral Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jiangfa</creatorcontrib><creatorcontrib>Li, Xiaoqing</creatorcontrib><creatorcontrib>Weng, Jun</creatorcontrib><creatorcontrib>Lei, Liping</creatorcontrib><creatorcontrib>Gong, Jianhua</creatorcontrib><creatorcontrib>Wang, Junyi</creatorcontrib><creatorcontrib>Li, Zhenghang</creatorcontrib><creatorcontrib>Zhang, Longmiao</creatorcontrib><creatorcontrib>He, Songqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jiangfa</au><au>Li, Xiaoqing</au><au>Weng, Jun</au><au>Lei, Liping</au><au>Gong, Jianhua</au><au>Wang, Junyi</au><au>Li, Zhenghang</au><au>Zhang, Longmiao</au><au>He, Songqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>97</volume><issue>52</issue><spage>e13964</spage><epage>e13964</epage><pages>e13964-e13964</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>This study aimed to compare the sensitivity and accuracy for the detection of small lesions in patients with hepatocellular carcinoma (HCC) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 64-slice computed tomography (CT) enhanced scanning, and to evaluate the necessity to perform MRI in patients diagnosed with HCC by CT.The clinical data from 209 patients with HCC diagnosed prior to surgery in the Affiliated Hospital of Guilin Medical University, China were retrospectively analyzed. The 64-slice dynamic contrast-enhanced multi-detector CT (MDCT) and 3.0 T Gd-EOB-DTPA DCE MRI procedures were successively carried out on all patients who were enrolled in a self-controlled study including detection and diagnosis of HCC lesions by MRI and CT, respectively.A total of 243 lesions were detected and both imaging methods could accurately detect lesions of diameter >2 cm. For lesions <2 cm, MRI detected 47, while CT detected 25 lesions indicating that the detection rate of MRI was 88% higher than that of CT. In addition, MRI detected lesions in 15 cases (7.81% in the total of 209 cases) that were not diagnosed by CT. Among these cases, 2 patients were diagnosed to have no lesion by CT.Gd-EOB-DTPA DCE-MRI performed as a routine check prior to surgery in HCC patients can improve the detection of small HCC lesions.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30593219</pmid><doi>10.1097/MD.0000000000013964</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine (Baltimore), 2018-12, Vol.97 (52), p.e13964-e13964 |
| issn | 0025-7974 1536-5964 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology China Contrast Media Female Gadolinium DTPA - administration & dosage Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Magnetic Resonance Imaging - methods Male Middle Aged Observational Study Retrospective Studies Sensitivity and Specificity Tomography, Spiral Computed - methods |
| title | Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging is more effective than enhanced 64-slice CT for the detection of small lesions in patients with hepatocellular carcinoma |
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