Dynamic nanoscale morphology of the ER surveyed by STED microscopy

The endoplasmic reticulum (ER) is composed of interconnected membrane sheets and tubules. Superresolution microscopy recently revealed densely packed, rapidly moving ER tubules mistaken for sheets by conventional light microscopy, highlighting the importance of revisiting classical views of ER struc...

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Veröffentlicht in:	The Journal of cell biology 2019-01, Vol.218 (1), p.83-96
Hauptverfasser:	Schroeder, Lena K, Barentine, Andrew E S, Merta, Holly, Schweighofer, Sarah, Zhang, Yongdeng, Baddeley, David, Bewersdorf, Joerg, Bahmanyar, Shirin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells (biology) Cellular biology Chlorocebus aethiops COS Cells Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - metabolism Cytoskeleton - ultrastructure Depletion Dynamic structural analysis Emission analysis Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Gene Expression Regulation Intracellular Membranes - drug effects Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Light microscopy Membrane structure Membrane structures Microscopy Microscopy - methods Microtubules - drug effects Microtubules - metabolism Microtubules - ultrastructure Molecular Imaging - methods Morphology Nocodazole - pharmacology Nogo Proteins - genetics Nogo Proteins - metabolism Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Quantitative analysis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Sheets Stimulated emission Time-Lapse Imaging - statistics & numerical data Tubules Tubulin Modulators - pharmacology
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