Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition

Metastasis is the most common cause of death in ovarian cancer patients but remains largely untreated. Epithelial‑mesenchymal transition (EMT) is critical for the conversion of early‑stage ovarian tumors into metastatic malignancies. Thus, investigating the signaling pathways promoting EMT may ident...

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Veröffentlicht in:	Oncology reports 2019-02, Vol.41 (2), p.917-927
Hauptverfasser:	Lu, Dan-Hua, Yang, Jiang, Gao, Li-Kun, Min, Jie, Tang, Jian-Ming, Hu, Ming, Li, Yang, Li, Su-Ting, Chen, Jing, Hong, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer therapies Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - mortality Carcinoma, Ovarian Epithelial - pathology Cell adhesion & migration Cell Line, Tumor Cell Proliferation - genetics Chemotherapy Datasets as Topic Disease Progression Down-Regulation Enzymes Epithelial-Mesenchymal Transition - genetics F-Box Proteins - genetics F-Box Proteins - metabolism Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kaplan-Meier Estimate Laboratories Medical prognosis Medical research Metastasis Middle Aged Oncogene Proteins - genetics Oncogene Proteins - metabolism Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovary - pathology Phosphatidylinositol 3-Kinases - metabolism Prognosis Proto-Oncogene Proteins c-akt - metabolism Radiation therapy Signal Transduction - genetics TOR Serine-Threonine Kinases - metabolism Tumorigenesis Tumors Up-Regulation Young Adult
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