Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples
Preeclampsia (PE) is a hypertensive disorder of pregnancy and one of the leading contributors to both maternal and perinatal morbidity and mortality. Reliable diagnostic parameters unique to the disorder that accurately define and diagnose PE are currently unavailable. Recent studies have revealed t...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2018-12, Vol.90 (24), p.14316-14320 |
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| creator | Do, Jamie P Cao, Kevin J Wei, Sylvia Laurent, Louise C Parast, Mana M Yang, Jerry |
| description | Preeclampsia (PE) is a hypertensive disorder of pregnancy and one of the leading contributors to both maternal and perinatal morbidity and mortality. Reliable diagnostic parameters unique to the disorder that accurately define and diagnose PE are currently unavailable. Recent studies have revealed that PE is accompanied by the accumulation of amyloidogenic deposits in the placenta and the presence of congophilic amyloid-like protein aggregates in the urine. Here, we evaluate the capability of an amyloid-targeting aryl cyano amide (ARCAM-1) fluorophore to identify PE patients from analysis of urine samples. Our results reveal that this probe can distinguish patients with PE from gestationally healthy patients and patients suffering from non-PE hypertension, highlighting the potential for amyloid-targeting fluorophores to help identify PE patients during pregnancy. |
| doi_str_mv | 10.1021/acs.analchem.8b03649 |
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Reliable diagnostic parameters unique to the disorder that accurately define and diagnose PE are currently unavailable. Recent studies have revealed that PE is accompanied by the accumulation of amyloidogenic deposits in the placenta and the presence of congophilic amyloid-like protein aggregates in the urine. Here, we evaluate the capability of an amyloid-targeting aryl cyano amide (ARCAM-1) fluorophore to identify PE patients from analysis of urine samples. Our results reveal that this probe can distinguish patients with PE from gestationally healthy patients and patients suffering from non-PE hypertension, highlighting the potential for amyloid-targeting fluorophores to help identify PE patients during pregnancy.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.8b03649</identifier><identifier>PMID: 30444965</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Amides - metabolism ; Amides - urine ; Amyloid - metabolism ; Amyloidogenesis ; Aromatic compounds ; Chemical compounds ; Chemistry ; Diagnostic systems ; Female ; Fluorescence ; Fluorophores ; Human wastes ; Humans ; Hypertension ; Morbidity ; Nitriles - metabolism ; Nitriles - urine ; Patients ; Placenta ; Pre-eclampsia ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - urine ; Preeclampsia ; Pregnancy ; Proteins ; Spectrometry, Fluorescence ; Urinalysis ; Urine</subject><ispartof>Analytical chemistry (Washington), 2018-12, Vol.90 (24), p.14316-14320</ispartof><rights>Copyright American Chemical Society Dec 18, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a477t-49ef67216aad0988db202f7b78b223f8992f9f814898375f4b989a350b6d29a3</citedby><cites>FETCH-LOGICAL-a477t-49ef67216aad0988db202f7b78b223f8992f9f814898375f4b989a350b6d29a3</cites><orcidid>0000-0002-8423-7376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b03649$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.8b03649$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,315,781,785,886,2766,27081,27929,27930,56743,56793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30444965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Do, Jamie P</creatorcontrib><creatorcontrib>Cao, Kevin J</creatorcontrib><creatorcontrib>Wei, Sylvia</creatorcontrib><creatorcontrib>Laurent, Louise C</creatorcontrib><creatorcontrib>Parast, Mana M</creatorcontrib><creatorcontrib>Yang, Jerry</creatorcontrib><title>Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Preeclampsia (PE) is a hypertensive disorder of pregnancy and one of the leading contributors to both maternal and perinatal morbidity and mortality. Reliable diagnostic parameters unique to the disorder that accurately define and diagnose PE are currently unavailable. Recent studies have revealed that PE is accompanied by the accumulation of amyloidogenic deposits in the placenta and the presence of congophilic amyloid-like protein aggregates in the urine. Here, we evaluate the capability of an amyloid-targeting aryl cyano amide (ARCAM-1) fluorophore to identify PE patients from analysis of urine samples. Our results reveal that this probe can distinguish patients with PE from gestationally healthy patients and patients suffering from non-PE hypertension, highlighting the potential for amyloid-targeting fluorophores to help identify PE patients during pregnancy.</description><subject>Amides - metabolism</subject><subject>Amides - urine</subject><subject>Amyloid - metabolism</subject><subject>Amyloidogenesis</subject><subject>Aromatic compounds</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorophores</subject><subject>Human wastes</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Morbidity</subject><subject>Nitriles - metabolism</subject><subject>Nitriles - urine</subject><subject>Patients</subject><subject>Placenta</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - urine</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Spectrometry, Fluorescence</subject><subject>Urinalysis</subject><subject>Urine</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EokvhGyBkiQuXLP4Xx74gbVeUViqiEuVsOYnddeXYi52AcueD42i3K-DAySPP772Z0QPgNUZrjAh-r7u81kH7bmeGtWgR5Uw-AStcE1RxIchTsEII0Yo0CJ2BFzk_IIQxwvw5OKOIMSZ5vQK_rnsTRmddp0cXA4wW3paq_GX40407eJuM6bwe9tlp2M7ws9F5Si7cw0s_xWRyZ0JnFp0OcDPMPrq-unChX5BNmj3czjrE0nK9gS7Aq2ko5LdiYeDX4utNfgmeWe2zeXV8z8Hd5ce77VV18-XT9XZzU2nWNGPFpLG8IZhr3SMpRN8SRGzTNqIlhFohJbHSCsyEFLSpLWulkJrWqOU9KcU5-HCw3U_tYPqy-Ji0V_vkBp1mFbVTf3eC26n7-ENxijGrWTF4dzRI8ftk8qgGV-73XgcTp6wIpjXGUlJU0Lf_oA9xSiWuheKsJpJxUSh2oLoUc07GnpbBSC0pq5KyekxZHVMusjd_HnISPcZaAHQAFvlp8H89fwPMebg4</recordid><startdate>20181218</startdate><enddate>20181218</enddate><creator>Do, Jamie P</creator><creator>Cao, Kevin J</creator><creator>Wei, Sylvia</creator><creator>Laurent, Louise C</creator><creator>Parast, Mana M</creator><creator>Yang, Jerry</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8423-7376</orcidid></search><sort><creationdate>20181218</creationdate><title>Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples</title><author>Do, Jamie P ; Cao, Kevin J ; Wei, Sylvia ; Laurent, Louise C ; Parast, Mana M ; Yang, Jerry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a477t-49ef67216aad0988db202f7b78b223f8992f9f814898375f4b989a350b6d29a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amides - metabolism</topic><topic>Amides - urine</topic><topic>Amyloid - metabolism</topic><topic>Amyloidogenesis</topic><topic>Aromatic compounds</topic><topic>Chemical compounds</topic><topic>Chemistry</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Fluorophores</topic><topic>Human wastes</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Morbidity</topic><topic>Nitriles - metabolism</topic><topic>Nitriles - urine</topic><topic>Patients</topic><topic>Placenta</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - urine</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Spectrometry, Fluorescence</topic><topic>Urinalysis</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Do, Jamie P</creatorcontrib><creatorcontrib>Cao, Kevin J</creatorcontrib><creatorcontrib>Wei, Sylvia</creatorcontrib><creatorcontrib>Laurent, Louise C</creatorcontrib><creatorcontrib>Parast, Mana M</creatorcontrib><creatorcontrib>Yang, Jerry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Do, Jamie P</au><au>Cao, Kevin J</au><au>Wei, Sylvia</au><au>Laurent, Louise C</au><au>Parast, Mana M</au><au>Yang, Jerry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. 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| subjects | Amides - metabolism Amides - urine Amyloid - metabolism Amyloidogenesis Aromatic compounds Chemical compounds Chemistry Diagnostic systems Female Fluorescence Fluorophores Human wastes Humans Hypertension Morbidity Nitriles - metabolism Nitriles - urine Patients Placenta Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - urine Preeclampsia Pregnancy Proteins Spectrometry, Fluorescence Urinalysis Urine |
| title | Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples |
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