Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV
OBJECTIVE:Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD ris...
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| Veröffentlicht in: | AIDS (London) 2019-02, Vol.33 (2), p.229-236 |
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| creator | Srinivasa, Suman Fitch, Kathleen V Torriani, Martin Zanni, Markella V Defilippi, Christopher Christenson, Robert Maehler, Patrick Looby, Sara E Lo, Janet Grinspoon, Steven K |
| description | OBJECTIVE:Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk.
DESIGNS/METHODS:One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evaluated.
RESULTS:Despite similar BMI and visceral adipose tissue (VAT), HIV-infected individuals had significantly lower subcutaneous adipose tissue [SAT, 199 (126–288) vs. 239 (148–358) cm, P = 0.04] than non-HIV infected individuals. Among HIV-infected individuals, reduced SAT inversely correlated with LpPLA2 (ρ = -0.19, P = 0.02) and hs-cTnT (ρ = -0.24, P = 0.004), whereas increased VAT significantly and positively related to LpPLA2 (ρ = 0.25, P = 0.003), oxLDL (ρ = 0.28, P = 0.0005), hs-cTnT (ρ = 0.28, P = 0.0007) and hsCRP (ρ = 0.32, P = |
| doi_str_mv | 10.1097/QAD.0000000000002060 |
| format | Article |
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DESIGNS/METHODS:One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evaluated.
RESULTS:Despite similar BMI and visceral adipose tissue (VAT), HIV-infected individuals had significantly lower subcutaneous adipose tissue [SAT, 199 (126–288) vs. 239 (148–358) cm, P = 0.04] than non-HIV infected individuals. Among HIV-infected individuals, reduced SAT inversely correlated with LpPLA2 (ρ = -0.19, P = 0.02) and hs-cTnT (ρ = -0.24, P = 0.004), whereas increased VAT significantly and positively related to LpPLA2 (ρ = 0.25, P = 0.003), oxLDL (ρ = 0.28, P = 0.0005), hs-cTnT (ρ = 0.28, P = 0.0007) and hsCRP (ρ = 0.32, P = < 0.0001). Similar analyses among the non-HIV infected individuals revealed significant relationships between SAT and LpPLA2 (ρ = -0.24, P = 0.05), as well as VAT and LpPLA2 (ρ = 0.37, P = 0.002), oxLDL (ρ = 0.24, P = 0.05) and hsCRP (ρ = 0.29, P = .02). In modelling performed among the HIV group, simultaneously controlling for VAT, SAT, age and relevant HIV-related parameters, reduced SAT was an independent predictor of LpPLA2 (P = 0.04) and hs-cTnT (P = 0.005) and increased VAT was an independent predictor of LpPLA2 (P = 0.001), oxLDL (P = 0.02), hs-cTnT (P = 0.04) and hsCRP (P = 0.04).
CONCLUSION:Fat redistribution phenotypes, characterized by SAT loss and/or VAT accumulation, may be linked to arterial injury and inflammation in HIV.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000002060</identifier><identifier>PMID: 30325779</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc</publisher><subject>Adult ; AIDS/HIV ; Atherosclerosis - pathology ; Biomarkers - analysis ; Blood Chemical Analysis ; Female ; HIV Infections - complications ; HIV Infections - pathology ; Humans ; Inflammation - pathology ; Intra-Abdominal Fat - pathology ; Male ; Middle Aged ; Radiography, Abdominal ; Subcutaneous Fat - pathology ; Tomography, X-Ray Computed</subject><ispartof>AIDS (London), 2019-02, Vol.33 (2), p.229-236</ispartof><rights>Copyright © 2019 Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4570-6a8a53b71084a052e1b966b79e892ece10d05429050d7712fe40f27806e4668d3</citedby><cites>FETCH-LOGICAL-c4570-6a8a53b71084a052e1b966b79e892ece10d05429050d7712fe40f27806e4668d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30325779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srinivasa, Suman</creatorcontrib><creatorcontrib>Fitch, Kathleen V</creatorcontrib><creatorcontrib>Torriani, Martin</creatorcontrib><creatorcontrib>Zanni, Markella V</creatorcontrib><creatorcontrib>Defilippi, Christopher</creatorcontrib><creatorcontrib>Christenson, Robert</creatorcontrib><creatorcontrib>Maehler, Patrick</creatorcontrib><creatorcontrib>Looby, Sara E</creatorcontrib><creatorcontrib>Lo, Janet</creatorcontrib><creatorcontrib>Grinspoon, Steven K</creatorcontrib><title>Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>OBJECTIVE:Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk.
DESIGNS/METHODS:One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evaluated.
RESULTS:Despite similar BMI and visceral adipose tissue (VAT), HIV-infected individuals had significantly lower subcutaneous adipose tissue [SAT, 199 (126–288) vs. 239 (148–358) cm, P = 0.04] than non-HIV infected individuals. Among HIV-infected individuals, reduced SAT inversely correlated with LpPLA2 (ρ = -0.19, P = 0.02) and hs-cTnT (ρ = -0.24, P = 0.004), whereas increased VAT significantly and positively related to LpPLA2 (ρ = 0.25, P = 0.003), oxLDL (ρ = 0.28, P = 0.0005), hs-cTnT (ρ = 0.28, P = 0.0007) and hsCRP (ρ = 0.32, P = < 0.0001). Similar analyses among the non-HIV infected individuals revealed significant relationships between SAT and LpPLA2 (ρ = -0.24, P = 0.05), as well as VAT and LpPLA2 (ρ = 0.37, P = 0.002), oxLDL (ρ = 0.24, P = 0.05) and hsCRP (ρ = 0.29, P = .02). In modelling performed among the HIV group, simultaneously controlling for VAT, SAT, age and relevant HIV-related parameters, reduced SAT was an independent predictor of LpPLA2 (P = 0.04) and hs-cTnT (P = 0.005) and increased VAT was an independent predictor of LpPLA2 (P = 0.001), oxLDL (P = 0.02), hs-cTnT (P = 0.04) and hsCRP (P = 0.04).
CONCLUSION:Fat redistribution phenotypes, characterized by SAT loss and/or VAT accumulation, may be linked to arterial injury and inflammation in HIV.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Atherosclerosis - pathology</subject><subject>Biomarkers - analysis</subject><subject>Blood Chemical Analysis</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - pathology</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiography, Abdominal</subject><subject>Subcutaneous Fat - pathology</subject><subject>Tomography, X-Ray Computed</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1O3DAYtKpWZaF9g6rysZeA7fgnuVRC0AISUkXV9mo58RdiSOLUdnbFtU9eLwuI9oAvlu2Z-TwzCH2g5JCSWh1dHZ8ekmeLEUleoRXlqiyEUPQ1WhEm66IuFdlD-zHeZJAgVfUW7ZWkZEKpeoX-fIfBJOen2LsZ-w6vXWwhmAGbyeK4NO2SzAR-idhYN_sI2MLsU8TJ49GEWwhxSzMhQXCZ5qabJdzds93UDWYc7-WxGf10na-sWzu7mCHijUs9Pr_49Q696fIZ3j_sB-jn1y8_Ts6Ly29nFyfHl0XLhSKFNJURZaMoqbghggFtaikbVUNVM2iBEksEZ3X2aJWirANOOqYqIoFLWdnyAH3e6c5LM4JtYUrZp56Dyz7utDdO__syuV5f-7WWJaWcsizw6UEg-N8LxKTHbVjDsAtIM8oor4XiWyjfQdvgYwzQPY2hRG_r07k-_X99mfbx-RefSI99ZUC1A2z8kAOPt8OygaB7MEPqX9b-C_YXqT0</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Srinivasa, Suman</creator><creator>Fitch, Kathleen V</creator><creator>Torriani, Martin</creator><creator>Zanni, Markella V</creator><creator>Defilippi, Christopher</creator><creator>Christenson, Robert</creator><creator>Maehler, Patrick</creator><creator>Looby, Sara E</creator><creator>Lo, Janet</creator><creator>Grinspoon, Steven K</creator><general>Copyright Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190201</creationdate><title>Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV</title><author>Srinivasa, Suman ; Fitch, Kathleen V ; Torriani, Martin ; Zanni, Markella V ; Defilippi, Christopher ; Christenson, Robert ; Maehler, Patrick ; Looby, Sara E ; Lo, Janet ; Grinspoon, Steven K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4570-6a8a53b71084a052e1b966b79e892ece10d05429050d7712fe40f27806e4668d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Atherosclerosis - pathology</topic><topic>Biomarkers - analysis</topic><topic>Blood Chemical Analysis</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - pathology</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiography, Abdominal</topic><topic>Subcutaneous Fat - pathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srinivasa, Suman</creatorcontrib><creatorcontrib>Fitch, Kathleen V</creatorcontrib><creatorcontrib>Torriani, Martin</creatorcontrib><creatorcontrib>Zanni, Markella V</creatorcontrib><creatorcontrib>Defilippi, Christopher</creatorcontrib><creatorcontrib>Christenson, Robert</creatorcontrib><creatorcontrib>Maehler, Patrick</creatorcontrib><creatorcontrib>Looby, Sara E</creatorcontrib><creatorcontrib>Lo, Janet</creatorcontrib><creatorcontrib>Grinspoon, Steven K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srinivasa, Suman</au><au>Fitch, Kathleen V</au><au>Torriani, Martin</au><au>Zanni, Markella V</au><au>Defilippi, Christopher</au><au>Christenson, Robert</au><au>Maehler, Patrick</au><au>Looby, Sara E</au><au>Lo, Janet</au><au>Grinspoon, Steven K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>33</volume><issue>2</issue><spage>229</spage><epage>236</epage><pages>229-236</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>OBJECTIVE:Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk.
DESIGNS/METHODS:One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evaluated.
RESULTS:Despite similar BMI and visceral adipose tissue (VAT), HIV-infected individuals had significantly lower subcutaneous adipose tissue [SAT, 199 (126–288) vs. 239 (148–358) cm, P = 0.04] than non-HIV infected individuals. Among HIV-infected individuals, reduced SAT inversely correlated with LpPLA2 (ρ = -0.19, P = 0.02) and hs-cTnT (ρ = -0.24, P = 0.004), whereas increased VAT significantly and positively related to LpPLA2 (ρ = 0.25, P = 0.003), oxLDL (ρ = 0.28, P = 0.0005), hs-cTnT (ρ = 0.28, P = 0.0007) and hsCRP (ρ = 0.32, P = < 0.0001). Similar analyses among the non-HIV infected individuals revealed significant relationships between SAT and LpPLA2 (ρ = -0.24, P = 0.05), as well as VAT and LpPLA2 (ρ = 0.37, P = 0.002), oxLDL (ρ = 0.24, P = 0.05) and hsCRP (ρ = 0.29, P = .02). In modelling performed among the HIV group, simultaneously controlling for VAT, SAT, age and relevant HIV-related parameters, reduced SAT was an independent predictor of LpPLA2 (P = 0.04) and hs-cTnT (P = 0.005) and increased VAT was an independent predictor of LpPLA2 (P = 0.001), oxLDL (P = 0.02), hs-cTnT (P = 0.04) and hsCRP (P = 0.04).
CONCLUSION:Fat redistribution phenotypes, characterized by SAT loss and/or VAT accumulation, may be linked to arterial injury and inflammation in HIV.</abstract><cop>England</cop><pub>Copyright Wolters Kluwer Health, Inc</pub><pmid>30325779</pmid><doi>10.1097/QAD.0000000000002060</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2019-02, Vol.33 (2), p.229-236 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult AIDS/HIV Atherosclerosis - pathology Biomarkers - analysis Blood Chemical Analysis Female HIV Infections - complications HIV Infections - pathology Humans Inflammation - pathology Intra-Abdominal Fat - pathology Male Middle Aged Radiography, Abdominal Subcutaneous Fat - pathology Tomography, X-Ray Computed |
| title | Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV |
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