Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities
Kaempferia parviflora (KP), a health-promoting herb, has been traditionally used for treating a variety of diseases. Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism-regulating activity, anticancer activity, vascu...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-15 |
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| creator | Feng, Shuo Li, Wen Li, Hongliang Chen, Dalin Deng, Dingsen |
| description | Kaempferia parviflora (KP), a health-promoting herb, has been traditionally used for treating a variety of diseases. Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism-regulating activity, anticancer activity, vascular relaxation and cardioprotective activity, sexual enhancing activity, neuroprotective activity, antiallergic, anti-inflammatory, and antioxidative activity, antiosteoarthritis activity, antimicroorganism activity, and transdermal permeable activity. These might be associated with increased mitochondrial functions and activated cGMP-NO signaling pathway. However, the underlying molecular mechanisms of KP and its methoxyflavones are still under investigation. The clinical applications of KP and its methoxyflavones may be limited due to their low bioavailability. But promising strategies are on the way. This review will comprehensively discuss the biological activities of KP and its methoxyflavones. |
| doi_str_mv | 10.1155/2018/4057456 |
| format | Article |
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Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism-regulating activity, anticancer activity, vascular relaxation and cardioprotective activity, sexual enhancing activity, neuroprotective activity, antiallergic, anti-inflammatory, and antioxidative activity, antiosteoarthritis activity, antimicroorganism activity, and transdermal permeable activity. These might be associated with increased mitochondrial functions and activated cGMP-NO signaling pathway. However, the underlying molecular mechanisms of KP and its methoxyflavones are still under investigation. The clinical applications of KP and its methoxyflavones may be limited due to their low bioavailability. But promising strategies are on the way. This review will comprehensively discuss the biological activities of KP and its methoxyflavones.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/4057456</identifier><identifier>PMID: 30643531</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adipocytes ; Antitumor activity ; Bioavailability ; Cyclic GMP ; Cytotoxicity ; Dietary supplements ; Drug dosages ; Ethanol ; Evidence-based medicine ; Exercise ; Health promotion ; Hematology ; Inflammation ; Kaempferia ; Lipids ; Medical research ; Medicine ; Medicine, Experimental ; Metabolism ; Metabolites ; Mitochondria ; Molecular modelling ; Neuroprotection ; Physical fitness ; Physiological aspects ; Review ; Signal transduction ; Therapeutic applications ; Toxicology</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-15</ispartof><rights>Copyright © 2018 Dalin Chen et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Dalin Chen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Dalin Chen et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-fad526031af5cc85e343cc5b1416feae96f79d7dbe4e75936e0d8ba83e24728f3</citedby><cites>FETCH-LOGICAL-c565t-fad526031af5cc85e343cc5b1416feae96f79d7dbe4e75936e0d8ba83e24728f3</cites><orcidid>0000-0002-4370-314X ; 0000-0001-9552-5018 ; 0000-0002-6119-2988 ; 0000-0002-5957-7125 ; 0000-0002-0017-9958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311295/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311295/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30643531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Feo, Vincenzo</contributor><contributor>Vincenzo De Feo</contributor><creatorcontrib>Feng, Shuo</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Li, Hongliang</creatorcontrib><creatorcontrib>Chen, Dalin</creatorcontrib><creatorcontrib>Deng, Dingsen</creatorcontrib><title>Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Kaempferia parviflora (KP), a health-promoting herb, has been traditionally used for treating a variety of diseases. Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism-regulating activity, anticancer activity, vascular relaxation and cardioprotective activity, sexual enhancing activity, neuroprotective activity, antiallergic, anti-inflammatory, and antioxidative activity, antiosteoarthritis activity, antimicroorganism activity, and transdermal permeable activity. These might be associated with increased mitochondrial functions and activated cGMP-NO signaling pathway. However, the underlying molecular mechanisms of KP and its methoxyflavones are still under investigation. The clinical applications of KP and its methoxyflavones may be limited due to their low bioavailability. But promising strategies are on the way. This review will comprehensively discuss the biological activities of KP and its methoxyflavones.</description><subject>Adipocytes</subject><subject>Antitumor activity</subject><subject>Bioavailability</subject><subject>Cyclic GMP</subject><subject>Cytotoxicity</subject><subject>Dietary supplements</subject><subject>Drug dosages</subject><subject>Ethanol</subject><subject>Evidence-based medicine</subject><subject>Exercise</subject><subject>Health promotion</subject><subject>Hematology</subject><subject>Inflammation</subject><subject>Kaempferia</subject><subject>Lipids</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine, Experimental</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mitochondria</subject><subject>Molecular modelling</subject><subject>Neuroprotection</subject><subject>Physical fitness</subject><subject>Physiological aspects</subject><subject>Review</subject><subject>Signal 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| subjects | Adipocytes Antitumor activity Bioavailability Cyclic GMP Cytotoxicity Dietary supplements Drug dosages Ethanol Evidence-based medicine Exercise Health promotion Hematology Inflammation Kaempferia Lipids Medical research Medicine Medicine, Experimental Metabolism Metabolites Mitochondria Molecular modelling Neuroprotection Physical fitness Physiological aspects Review Signal transduction Therapeutic applications Toxicology |
| title | Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities |
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