Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer
Red blood cell distribution width (RDW) indicates the heterogeneity in the size of circulating red blood cells. Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors. To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-7 |
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| creator | Zhu, Xianjin Cao, Yingping Lin, Qing Lu, Pingxia Lin, Zhen Kang, Yanli Huang, Zhengyuan Song, Yanfang Cai, Zhaolian |
| description | Red blood cell distribution width (RDW) indicates the heterogeneity in the size of circulating red blood cells. Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors. To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal cancer (CRC), we evaluated 783 newly diagnosed CRC patients, 463 colorectal adenomas (CA) patients, and 331 healthy controls from June 2015 to October 2017 at Fujian Medical University Union Hospital. We found that RDW levels were significantly higher in CRC groups compared with both the CA and healthy control groups (P |
| doi_str_mv | 10.1155/2018/9858943 |
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Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors. To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal cancer (CRC), we evaluated 783 newly diagnosed CRC patients, 463 colorectal adenomas (CA) patients, and 331 healthy controls from June 2015 to October 2017 at Fujian Medical University Union Hospital. We found that RDW levels were significantly higher in CRC groups compared with both the CA and healthy control groups (P<0.001). Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) for RDW, CEA, and CA19-9 was 0.643, 0.742, and 0.629 in discriminating CRC patients from healthy controls, respectively. When RDW cut-off value of 13.95 was applied, we distinguished CRC patients from healthy controls with a sensitivity of 41% and a specificity of 94%. Moreover, combined detection of RDW, CEA, and CA19-9 appeared to be a better diagnostic performance with a sensitivity of 56% and a specificity of 99%. However, RDW had little diagnostic value in the differential diagnosis between CRC patients and CA patients. More importantly, RDW levels were significantly associated with TNM stage, pT stage, pM stage, and tumor size among CRC patients. Overall, our study suggested that RDW might be an auxiliary biomarker for diagnosis and prognosis of CRC.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/9858943</identifier><identifier>PMID: 30643826</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Anemia ; Biomarkers ; Blood circulation ; Blood tests ; Breast cancer ; Cancer ; Cardiology ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Diagnosis ; Diagnostic systems ; Differential diagnosis ; Endometrial cancer ; Erythrocytes ; Esophageal cancer ; Health care ; Heterogeneity ; Laboratories ; Medical colleges ; Medical prognosis ; Medical research ; Medicine, Experimental ; Mortality ; Patients ; Prognosis ; Sensitivity ; Statistical analysis ; Studies ; Tumors</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-7</ispartof><rights>Copyright © 2018 Yanfang Song et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Yanfang Song et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Yanfang Song et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-8c55fb6701cac7a3e9845944590a905d855261b2d3b243a98d1e6e0061ee106a3</citedby><cites>FETCH-LOGICAL-c499t-8c55fb6701cac7a3e9845944590a905d855261b2d3b243a98d1e6e0061ee106a3</cites><orcidid>0000-0003-0049-9289</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30643826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Galani, Vasiliki</contributor><creatorcontrib>Zhu, Xianjin</creatorcontrib><creatorcontrib>Cao, Yingping</creatorcontrib><creatorcontrib>Lin, Qing</creatorcontrib><creatorcontrib>Lu, Pingxia</creatorcontrib><creatorcontrib>Lin, Zhen</creatorcontrib><creatorcontrib>Kang, Yanli</creatorcontrib><creatorcontrib>Huang, Zhengyuan</creatorcontrib><creatorcontrib>Song, Yanfang</creatorcontrib><creatorcontrib>Cai, Zhaolian</creatorcontrib><title>Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Red blood cell distribution width (RDW) indicates the heterogeneity in the size of circulating red blood cells. Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors. To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal cancer (CRC), we evaluated 783 newly diagnosed CRC patients, 463 colorectal adenomas (CA) patients, and 331 healthy controls from June 2015 to October 2017 at Fujian Medical University Union Hospital. We found that RDW levels were significantly higher in CRC groups compared with both the CA and healthy control groups (P<0.001). Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) for RDW, CEA, and CA19-9 was 0.643, 0.742, and 0.629 in discriminating CRC patients from healthy controls, respectively. When RDW cut-off value of 13.95 was applied, we distinguished CRC patients from healthy controls with a sensitivity of 41% and a specificity of 94%. Moreover, combined detection of RDW, CEA, and CA19-9 appeared to be a better diagnostic performance with a sensitivity of 56% and a specificity of 99%. However, RDW had little diagnostic value in the differential diagnosis between CRC patients and CA patients. More importantly, RDW levels were significantly associated with TNM stage, pT stage, pM stage, and tumor size among CRC patients. Overall, our study suggested that RDW might be an auxiliary biomarker for diagnosis and prognosis of CRC.</description><subject>Anemia</subject><subject>Biomarkers</subject><subject>Blood circulation</subject><subject>Blood tests</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Differential diagnosis</subject><subject>Endometrial cancer</subject><subject>Erythrocytes</subject><subject>Esophageal cancer</subject><subject>Health care</subject><subject>Heterogeneity</subject><subject>Laboratories</subject><subject>Medical colleges</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, 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Zhaolian</au><au>Galani, Vasiliki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Red blood cell distribution width (RDW) indicates the heterogeneity in the size of circulating red blood cells. Increasing studies showed that RDW may be a diagnostic and prognostic marker in various tumors. To investigate the value of RDW as a biomarker in the diagnosis and prognosis of colorectal cancer (CRC), we evaluated 783 newly diagnosed CRC patients, 463 colorectal adenomas (CA) patients, and 331 healthy controls from June 2015 to October 2017 at Fujian Medical University Union Hospital. We found that RDW levels were significantly higher in CRC groups compared with both the CA and healthy control groups (P<0.001). Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) for RDW, CEA, and CA19-9 was 0.643, 0.742, and 0.629 in discriminating CRC patients from healthy controls, respectively. When RDW cut-off value of 13.95 was applied, we distinguished CRC patients from healthy controls with a sensitivity of 41% and a specificity of 94%. Moreover, combined detection of RDW, CEA, and CA19-9 appeared to be a better diagnostic performance with a sensitivity of 56% and a specificity of 99%. However, RDW had little diagnostic value in the differential diagnosis between CRC patients and CA patients. More importantly, RDW levels were significantly associated with TNM stage, pT stage, pM stage, and tumor size among CRC patients. Overall, our study suggested that RDW might be an auxiliary biomarker for diagnosis and prognosis of CRC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30643826</pmid><doi>10.1155/2018/9858943</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0049-9289</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anemia Biomarkers Blood circulation Blood tests Breast cancer Cancer Cardiology Colonoscopy Colorectal cancer Colorectal carcinoma Diagnosis Diagnostic systems Differential diagnosis Endometrial cancer Erythrocytes Esophageal cancer Health care Heterogeneity Laboratories Medical colleges Medical prognosis Medical research Medicine, Experimental Mortality Patients Prognosis Sensitivity Statistical analysis Studies Tumors |
| title | Clinical Usefulness and Prognostic Value of Red Cell Distribution Width in Colorectal Cancer |
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