Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain, T4 is converted to the active form T3 by type 2 deiodinase (D2). Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) i...

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Veröffentlicht in:	The Journal of clinical investigation 2019-01, Vol.129 (1), p.230-245
Hauptverfasser:	Jo, Sungro, Fonseca, Tatiana L, Bocco, Barbara M L C, Fernandes, Gustavo W, McAninch, Elizabeth A, Bolin, Anaysa P, Da Conceição, Rodrigo R, Werneck-de-Castro, Joao Pedro, Ignacio, Daniele L, Egri, Péter, Németh, Dorottya, Fekete, Csaba, Bernardi, Maria Martha, Leitch, Victoria D, Mannan, Naila S, Curry, Katharine F, Butterfield, Natalie C, Bassett, J H Duncan, Williams, Graham R, Gereben, Balázs, Ribeiro, Miriam O, Bianco, Antonio C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino Acid Substitution Animals Biomedical research Brain - enzymology Brain - pathology Butyric acid Care and treatment Cognition Cognition & reasoning CRISPR Diabetes Endoplasmic reticulum Endoplasmic Reticulum - enzymology Endoplasmic Reticulum - genetics Endoplasmic Reticulum Stress Gene expression Gene polymorphism Genetic aspects Genetic polymorphisms Golgi apparatus Golgi Apparatus - enzymology Golgi Apparatus - genetics Health aspects HEK293 Cells Humans Hypothyroidism Hypothyroidism - drug therapy Hypothyroidism - enzymology Hypothyroidism - genetics Hypothyroidism - pathology Insulin resistance Iodide peroxidase Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II Mice Mice, Transgenic Mutation, Missense Neurobiology Neurosciences Phenotypes Physical activity Polymorphism Polymorphism, Genetic Protein folding Proteins Thyroid Thyroid gland Thyroid hormones Thyroxine Thyroxine - therapeutic use Triiodothyronine Triiodothyronine - therapeutic use Unfolded Protein Response
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