Bexarotene - a novel modulator of AURKA and the primary cilium in VHL -deficient cells

Loss of the gene von Hippel-Lindau ( ) is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We developed an image-based high-throughput screening (HTS) assay using a dual-labeling image analysis strategy that identifies both the cilium and th...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of cell science 2018-12, Vol.131 (24)
Hauptverfasser:	Chowdhury, Pratim, Powell, Reid T, Stephan, Clifford, Uray, Ivan P, Talley, Tia, Karki, Menuka, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A, Davies, Peter, Dere, Ruhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora Kinase A - genetics Aurora Kinase A - metabolism Bexarotene - pharmacology Carcinoma, Renal Cell - drug therapy Cell Line, Tumor Cilia - drug effects Cilia - metabolism Gene Expression Regulation, Neoplastic - drug effects Humans Mutation - drug effects Mutation - genetics Von Hippel-Lindau Tumor Suppressor Protein - drug effects Von Hippel-Lindau Tumor Suppressor Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!