miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population

Absstract Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene....

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-01, Vol.23 (1), p.167-176
Hauptverfasser:	Huang, Suli, Lv, Ziquan, Wen, Ying, Wei, Yazhen, Zhou, Li, Ke, Yuebin, Zhang, Yanwei, Xu, Qianhui, Li, Lu, Guo, Yinsheng, Li, Di, Xie, Changhui, Guo, Yi, Cheng, Jinquan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Aged Asian Continental Ancestry Group - genetics Bioinformatics Blood cells Blood levels Brain Ischemia - blood Brain Ischemia - genetics Case-Control Studies Cell Line Chromosome 3 Female Gene Expression Regulation Health risks Humans ischaemic stroke Kinases Male Mean Platelet Volume MicroRNAs - genetics Middle Aged miRNA miR‐129‐2‐3p Original platelet Platelets Protein-tyrosine kinase Regression analysis Spleen spleen tyrosine kinase Stroke - blood Stroke - genetics Susceptibility Syk Kinase - blood Syk Kinase - genetics Syk protein Transfection Western blotting
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