miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population
Absstract Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene....
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2019-01, Vol.23 (1), p.167-176 |
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| creator | Huang, Suli Lv, Ziquan Wen, Ying Wei, Yazhen Zhou, Li Ke, Yuebin Zhang, Yanwei Xu, Qianhui Li, Lu Guo, Yinsheng Li, Di Xie, Changhui Guo, Yi Cheng, Jinquan |
| description | Absstract
Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene. miRNAs were firstly screened by bioinformatics predicting tool. The expression levels of SYK gene were detected by qRT‐PCR and western blotting, respectively, after miRNA transfection. Luciferase reporter assay was applied to investigate the direct binding between miRNAs and target gene. miRNA levels were detected by miRNA TaqMan assays in the blood cells of 270 IS patients and 270 control volunteers. Results suggest that SYK gene might be a direct target of miR‐129‐2‐3p. The blood level of miR‐129‐2‐3p was significantly lower in IS patients (P |
| doi_str_mv | 10.1111/jcmm.13901 |
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Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene. miRNAs were firstly screened by bioinformatics predicting tool. The expression levels of SYK gene were detected by qRT‐PCR and western blotting, respectively, after miRNA transfection. Luciferase reporter assay was applied to investigate the direct binding between miRNAs and target gene. miRNA levels were detected by miRNA TaqMan assays in the blood cells of 270 IS patients and 270 control volunteers. Results suggest that SYK gene might be a direct target of miR‐129‐2‐3p. The blood level of miR‐129‐2‐3p was significantly lower in IS patients (P < 0.05), and negatively associated with the risk of IS (adjusted OR: 0.88; 95% CI: 0.80‐0.98; P = 0.021) by multivariable logistic regression analysis. The blood levels of SYK gene were significantly higher in IS patients, and miR‐129‐2‐3p expression was negatively correlated with mean platelet volume. In summary, our study suggests that miR‐129‐2‐3p might be involved in the pathogenesis of IS through interrupting SYK expression and the platelet function, and further investigation is needed to explore the underlying mechanism.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.13901</identifier><identifier>PMID: 30499219</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>3' Untranslated Regions ; Aged ; Asian Continental Ancestry Group - genetics ; Bioinformatics ; Blood cells ; Blood levels ; Brain Ischemia - blood ; Brain Ischemia - genetics ; Case-Control Studies ; Cell Line ; Chromosome 3 ; Female ; Gene Expression Regulation ; Health risks ; Humans ; ischaemic stroke ; Kinases ; Male ; Mean Platelet Volume ; MicroRNAs - genetics ; Middle Aged ; miRNA ; miR‐129‐2‐3p ; Original ; platelet ; Platelets ; Protein-tyrosine kinase ; Regression analysis ; Spleen ; spleen tyrosine kinase ; Stroke - blood ; Stroke - genetics ; Susceptibility ; Syk Kinase - blood ; Syk Kinase - genetics ; Syk protein ; Transfection ; Western blotting</subject><ispartof>Journal of cellular and molecular medicine, 2019-01, Vol.23 (1), p.167-176</ispartof><rights>2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4481-ded7b3745a0e25c058d89117ca2e2f04aae113636ab78055fb778897c8c80e143</citedby><cites>FETCH-LOGICAL-c4481-ded7b3745a0e25c058d89117ca2e2f04aae113636ab78055fb778897c8c80e143</cites><orcidid>0000-0002-8751-2898</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307781/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307781/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30499219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Suli</creatorcontrib><creatorcontrib>Lv, Ziquan</creatorcontrib><creatorcontrib>Wen, Ying</creatorcontrib><creatorcontrib>Wei, Yazhen</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Ke, Yuebin</creatorcontrib><creatorcontrib>Zhang, Yanwei</creatorcontrib><creatorcontrib>Xu, Qianhui</creatorcontrib><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Guo, Yinsheng</creatorcontrib><creatorcontrib>Li, Di</creatorcontrib><creatorcontrib>Xie, Changhui</creatorcontrib><creatorcontrib>Guo, Yi</creatorcontrib><creatorcontrib>Cheng, Jinquan</creatorcontrib><title>miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Absstract
Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene. miRNAs were firstly screened by bioinformatics predicting tool. The expression levels of SYK gene were detected by qRT‐PCR and western blotting, respectively, after miRNA transfection. Luciferase reporter assay was applied to investigate the direct binding between miRNAs and target gene. miRNA levels were detected by miRNA TaqMan assays in the blood cells of 270 IS patients and 270 control volunteers. Results suggest that SYK gene might be a direct target of miR‐129‐2‐3p. The blood level of miR‐129‐2‐3p was significantly lower in IS patients (P < 0.05), and negatively associated with the risk of IS (adjusted OR: 0.88; 95% CI: 0.80‐0.98; P = 0.021) by multivariable logistic regression analysis. The blood levels of SYK gene were significantly higher in IS patients, and miR‐129‐2‐3p expression was negatively correlated with mean platelet volume. In summary, our study suggests that miR‐129‐2‐3p might be involved in the pathogenesis of IS through interrupting SYK expression and the platelet function, and further investigation is needed to explore the underlying mechanism.</description><subject>3' Untranslated Regions</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Bioinformatics</subject><subject>Blood cells</subject><subject>Blood levels</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - genetics</subject><subject>Case-Control Studies</subject><subject>Cell Line</subject><subject>Chromosome 3</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Health risks</subject><subject>Humans</subject><subject>ischaemic stroke</subject><subject>Kinases</subject><subject>Male</subject><subject>Mean Platelet Volume</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>miR‐129‐2‐3p</subject><subject>Original</subject><subject>platelet</subject><subject>Platelets</subject><subject>Protein-tyrosine kinase</subject><subject>Regression analysis</subject><subject>Spleen</subject><subject>spleen tyrosine kinase</subject><subject>Stroke - blood</subject><subject>Stroke - genetics</subject><subject>Susceptibility</subject><subject>Syk Kinase - blood</subject><subject>Syk Kinase - genetics</subject><subject>Syk protein</subject><subject>Transfection</subject><subject>Western blotting</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kd1qFDEUx4MotlZvfAAJeCPC1pxJZpK5EWTxo7VF8OPCq5DNnNnJdmYyJhnL3vkIPmOfpKm7FvXCQHIO5MePc_gT8hjYMeTzYmOH4Rh4zeAOOYRSFQtRc3F334Pi6oA8iHHDGK8ydp8ccCbquoD6kMyD-3j14ycUdX6LfPlEGxfQpn5LkwlrTJF--vqernFEasaGmhi9dSZhpJcudTR1SIOLF9S31EXbGRycpTEFf4HUjdTQZedGjEgnP829Sc6PD8m91vQRH-3rEfny5vXn5bvF2Ye3J8tXZwsrhIJFg41ccSlKw7AoLStVo2oAaU2BRcuEMQjAK16ZlVSsLNuVlErV0iqrGILgR-TlzjvNqwEbi2MKptdTcIMJW-2N03__jK7Ta_9dV5xlFWTBs70g-G8zxqSHvCP2vRnRz1EXIIAJAVJm9Ok_6MbPYczrZapiinMBVaae7ygbfIwB29thgOmbNPVNmvpXmhl-8uf4t-jv-DIAO-DS9bj9j0qfLs_Pd9Jrl_ms6g</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Huang, Suli</creator><creator>Lv, Ziquan</creator><creator>Wen, Ying</creator><creator>Wei, Yazhen</creator><creator>Zhou, Li</creator><creator>Ke, Yuebin</creator><creator>Zhang, Yanwei</creator><creator>Xu, Qianhui</creator><creator>Li, Lu</creator><creator>Guo, Yinsheng</creator><creator>Li, Di</creator><creator>Xie, Changhui</creator><creator>Guo, Yi</creator><creator>Cheng, Jinquan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8751-2898</orcidid></search><sort><creationdate>201901</creationdate><title>miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population</title><author>Huang, Suli ; Lv, Ziquan ; Wen, Ying ; Wei, Yazhen ; Zhou, Li ; Ke, Yuebin ; Zhang, Yanwei ; Xu, Qianhui ; Li, Lu ; Guo, Yinsheng ; Li, Di ; Xie, Changhui ; Guo, Yi ; Cheng, Jinquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4481-ded7b3745a0e25c058d89117ca2e2f04aae113636ab78055fb778897c8c80e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3' Untranslated Regions</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Bioinformatics</topic><topic>Blood cells</topic><topic>Blood levels</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - genetics</topic><topic>Case-Control Studies</topic><topic>Cell Line</topic><topic>Chromosome 3</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Health risks</topic><topic>Humans</topic><topic>ischaemic stroke</topic><topic>Kinases</topic><topic>Male</topic><topic>Mean Platelet Volume</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>miR‐129‐2‐3p</topic><topic>Original</topic><topic>platelet</topic><topic>Platelets</topic><topic>Protein-tyrosine kinase</topic><topic>Regression analysis</topic><topic>Spleen</topic><topic>spleen tyrosine kinase</topic><topic>Stroke - blood</topic><topic>Stroke - genetics</topic><topic>Susceptibility</topic><topic>Syk Kinase - blood</topic><topic>Syk Kinase - genetics</topic><topic>Syk protein</topic><topic>Transfection</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Suli</creatorcontrib><creatorcontrib>Lv, Ziquan</creatorcontrib><creatorcontrib>Wen, Ying</creatorcontrib><creatorcontrib>Wei, Yazhen</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Ke, Yuebin</creatorcontrib><creatorcontrib>Zhang, Yanwei</creatorcontrib><creatorcontrib>Xu, Qianhui</creatorcontrib><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Guo, Yinsheng</creatorcontrib><creatorcontrib>Li, Di</creatorcontrib><creatorcontrib>Xie, Changhui</creatorcontrib><creatorcontrib>Guo, Yi</creatorcontrib><creatorcontrib>Cheng, Jinquan</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Suli</au><au>Lv, Ziquan</au><au>Wen, Ying</au><au>Wei, Yazhen</au><au>Zhou, Li</au><au>Ke, Yuebin</au><au>Zhang, Yanwei</au><au>Xu, Qianhui</au><au>Li, Lu</au><au>Guo, Yinsheng</au><au>Li, Di</au><au>Xie, Changhui</au><au>Guo, Yi</au><au>Cheng, Jinquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2019-01</date><risdate>2019</risdate><volume>23</volume><issue>1</issue><spage>167</spage><epage>176</epage><pages>167-176</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Absstract
Spleen tyrosine kinase (SYK) gene has been identified as novel susceptibility locus for ischaemic stroke (IS) previously. However, regulation of SYK gene remains unknown in IS. In this study, we aimed to identify miRNAs that might be involved in the development of IS by targeting SYK gene. miRNAs were firstly screened by bioinformatics predicting tool. The expression levels of SYK gene were detected by qRT‐PCR and western blotting, respectively, after miRNA transfection. Luciferase reporter assay was applied to investigate the direct binding between miRNAs and target gene. miRNA levels were detected by miRNA TaqMan assays in the blood cells of 270 IS patients and 270 control volunteers. Results suggest that SYK gene might be a direct target of miR‐129‐2‐3p. The blood level of miR‐129‐2‐3p was significantly lower in IS patients (P < 0.05), and negatively associated with the risk of IS (adjusted OR: 0.88; 95% CI: 0.80‐0.98; P = 0.021) by multivariable logistic regression analysis. The blood levels of SYK gene were significantly higher in IS patients, and miR‐129‐2‐3p expression was negatively correlated with mean platelet volume. In summary, our study suggests that miR‐129‐2‐3p might be involved in the pathogenesis of IS through interrupting SYK expression and the platelet function, and further investigation is needed to explore the underlying mechanism.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>30499219</pmid><doi>10.1111/jcmm.13901</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8751-2898</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated Regions Aged Asian Continental Ancestry Group - genetics Bioinformatics Blood cells Blood levels Brain Ischemia - blood Brain Ischemia - genetics Case-Control Studies Cell Line Chromosome 3 Female Gene Expression Regulation Health risks Humans ischaemic stroke Kinases Male Mean Platelet Volume MicroRNAs - genetics Middle Aged miRNA miR‐129‐2‐3p Original platelet Platelets Protein-tyrosine kinase Regression analysis Spleen spleen tyrosine kinase Stroke - blood Stroke - genetics Susceptibility Syk Kinase - blood Syk Kinase - genetics Syk protein Transfection Western blotting |
| title | miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population |
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