Protective effects of dexmedetomidine on lung in rats with one-lung ventilation
Protective effect of dexmedetomidine (DEX) on the lungs of one-lung ventilation (OLV) rat model and its effect on inflammatory factors were investigated. Ninety-two rats were selected and divided into groups A, B, C and D (n=23) according to the principle of similar body weight. OLV rat model was es...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-01, Vol.17 (1), p.187-192 |
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| creator | Wang, Juntao Yi, Xuanlong Jiang, Lili Dong, He Feng, Wei Wang, Shuntao Chu, Chunqin |
| description | Protective effect of dexmedetomidine (DEX) on the lungs of one-lung ventilation (OLV) rat model and its effect on inflammatory factors were investigated. Ninety-two rats were selected and divided into groups A, B, C and D (n=23) according to the principle of similar body weight. OLV rat model was established. Before modeling (15 min), rats in group C were injected with sodium chloride. Rats in group D were injected with DEX at a speed of 5 µg/kg/h. Group A rats were ventilated in both lungs for 2 h. Rats in groups B and C (0.9% sodium chloride injection + OLV) and in group D (DEX + OLV) were subjected to OLV for 2 h and bilateral ventilation for 10 min. Concentrations of interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) in lung tissue of rats were detected by ELISA. The malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity in rat lung tissue were detected by radioimmunoassay. Wet weight (W)/dry weight (D) of lung tissue was calculated and indexes of the four groups of rats were compared. Compared with group A, IL-6, TNF-α and MDA concentrations and W/D of lung tissue of rats in groups B, C and D were significantly increased (p |
| doi_str_mv | 10.3892/etm.2018.6952 |
| format | Article |
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Ninety-two rats were selected and divided into groups A, B, C and D (n=23) according to the principle of similar body weight. OLV rat model was established. Before modeling (15 min), rats in group C were injected with sodium chloride. Rats in group D were injected with DEX at a speed of 5 µg/kg/h. Group A rats were ventilated in both lungs for 2 h. Rats in groups B and C (0.9% sodium chloride injection + OLV) and in group D (DEX + OLV) were subjected to OLV for 2 h and bilateral ventilation for 10 min. Concentrations of interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) in lung tissue of rats were detected by ELISA. The malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity in rat lung tissue were detected by radioimmunoassay. Wet weight (W)/dry weight (D) of lung tissue was calculated and indexes of the four groups of rats were compared. Compared with group A, IL-6, TNF-α and MDA concentrations and W/D of lung tissue of rats in groups B, C and D were significantly increased (p<0.05); SOD activity and IL-10 concentration were significantly decreased (p<0.01). Compared with groups B and C, the concentrations of IL-6, TNF-α and W/D in rats of group D were significantly decreased (p<0.01), but IL-10 significantly increased (p<0.01). Compared with groups B and C, the MDA concentration in lung tissue of rats in group D was significantly decreased (p<0.01), but SOD activity significantly increased (p<0.01). DEX can inhibit the production of inflammatory factors in the development and progression of pulmonary inflammation. It can inhibit lipid peroxidation, relieve pulmonary edema, and reduce lung injury after OLV, sin order to protect the lung.]]></description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6952</identifier><identifier>PMID: 30651781</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Blood pressure ; Catheters ; Dexmedetomidine ; Dosage and administration ; Edema ; Free radicals ; Heart rate ; Humidity ; Hypoxia ; Inflammation ; Ischemia ; Laboratory animals ; Lipid peroxidation ; Lipids ; Lung ; Lungs ; Mechanical ventilation ; Methods ; Ostomy ; Pathogenesis ; Physiology ; Rodents ; Surgery ; Thoracic surgery ; Tumor necrosis factor-TNF ; Ventilation ; Ventilators</subject><ispartof>Experimental and therapeutic medicine, 2019-01, Vol.17 (1), p.187-192</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Wang et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c508t-1351fb52c22a7cfdfe85b5e31b2680dd5f15c804e8f492e8b1fc75da659b121a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307433/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307433/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30651781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Juntao</creatorcontrib><creatorcontrib>Yi, Xuanlong</creatorcontrib><creatorcontrib>Jiang, Lili</creatorcontrib><creatorcontrib>Dong, He</creatorcontrib><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Wang, Shuntao</creatorcontrib><creatorcontrib>Chu, Chunqin</creatorcontrib><title>Protective effects of dexmedetomidine on lung in rats with one-lung ventilation</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description><![CDATA[Protective effect of dexmedetomidine (DEX) on the lungs of one-lung ventilation (OLV) rat model and its effect on inflammatory factors were investigated. Ninety-two rats were selected and divided into groups A, B, C and D (n=23) according to the principle of similar body weight. OLV rat model was established. Before modeling (15 min), rats in group C were injected with sodium chloride. Rats in group D were injected with DEX at a speed of 5 µg/kg/h. Group A rats were ventilated in both lungs for 2 h. Rats in groups B and C (0.9% sodium chloride injection + OLV) and in group D (DEX + OLV) were subjected to OLV for 2 h and bilateral ventilation for 10 min. Concentrations of interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) in lung tissue of rats were detected by ELISA. The malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity in rat lung tissue were detected by radioimmunoassay. Wet weight (W)/dry weight (D) of lung tissue was calculated and indexes of the four groups of rats were compared. Compared with group A, IL-6, TNF-α and MDA concentrations and W/D of lung tissue of rats in groups B, C and D were significantly increased (p<0.05); SOD activity and IL-10 concentration were significantly decreased (p<0.01). Compared with groups B and C, the concentrations of IL-6, TNF-α and W/D in rats of group D were significantly decreased (p<0.01), but IL-10 significantly increased (p<0.01). Compared with groups B and C, the MDA concentration in lung tissue of rats in group D was significantly decreased (p<0.01), but SOD activity significantly increased (p<0.01). DEX can inhibit the production of inflammatory factors in the development and progression of pulmonary inflammation. It can inhibit lipid peroxidation, relieve pulmonary edema, and reduce lung injury after OLV, sin order to protect the lung.]]></description><subject>Blood pressure</subject><subject>Catheters</subject><subject>Dexmedetomidine</subject><subject>Dosage and administration</subject><subject>Edema</subject><subject>Free radicals</subject><subject>Heart rate</subject><subject>Humidity</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Lung</subject><subject>Lungs</subject><subject>Mechanical ventilation</subject><subject>Methods</subject><subject>Ostomy</subject><subject>Pathogenesis</subject><subject>Physiology</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Thoracic surgery</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1v1DAQhi0EolXpkSuKxIVLFn_EH7kgVRUUpErlAGfLccZbV4ldHGeBf89suxSKsA8ejZ95PTMeQl4yuhGm52-hzhtOmdmoXvIn5JjpnreMMvn0YNPesCNyuiw3FJdUzBj5nBwJqiTThh2Tq88lV_A17qCBENBamhyaEX7MMELNcxxjgianZlrTtompKQ6R77FeoxPaO-8OUo2TqzGnF-RZcNMCp4fzhHz98P7L-cf28uri0_nZZeslNbVlQrIwSO45d9qHMYCRgwTBBq4MHUcZmPSGdmBC13MwAwtey9Ep2Q-MMydOyLt73dt1wEw9ZlDcZG9LnF35abOL9vFNitd2m3dWCao7IVDgzUGg5G8rLNXOcfEwTS5BXhfLsX9CaWwaoq__QW_yWhKWh5TimmrTdX-orZvAxhQyvuv3ovZMaoZaWlGkNv-hcI8wR48dDRH9jwLa-wBf8rIUCA81Mmr3Q2BxCOx-COx-CJB_9XdjHujfXy5-Ad0zrKA</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Wang, Juntao</creator><creator>Yi, Xuanlong</creator><creator>Jiang, Lili</creator><creator>Dong, He</creator><creator>Feng, Wei</creator><creator>Wang, Shuntao</creator><creator>Chu, Chunqin</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Protective effects of dexmedetomidine on lung in rats with one-lung ventilation</title><author>Wang, Juntao ; Yi, Xuanlong ; Jiang, Lili ; Dong, He ; Feng, Wei ; Wang, Shuntao ; Chu, Chunqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-1351fb52c22a7cfdfe85b5e31b2680dd5f15c804e8f492e8b1fc75da659b121a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood pressure</topic><topic>Catheters</topic><topic>Dexmedetomidine</topic><topic>Dosage and administration</topic><topic>Edema</topic><topic>Free radicals</topic><topic>Heart rate</topic><topic>Humidity</topic><topic>Hypoxia</topic><topic>Inflammation</topic><topic>Ischemia</topic><topic>Laboratory animals</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Lung</topic><topic>Lungs</topic><topic>Mechanical ventilation</topic><topic>Methods</topic><topic>Ostomy</topic><topic>Pathogenesis</topic><topic>Physiology</topic><topic>Rodents</topic><topic>Surgery</topic><topic>Thoracic surgery</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Juntao</creatorcontrib><creatorcontrib>Yi, Xuanlong</creatorcontrib><creatorcontrib>Jiang, Lili</creatorcontrib><creatorcontrib>Dong, He</creatorcontrib><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Wang, Shuntao</creatorcontrib><creatorcontrib>Chu, Chunqin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Juntao</au><au>Yi, Xuanlong</au><au>Jiang, Lili</au><au>Dong, He</au><au>Feng, Wei</au><au>Wang, Shuntao</au><au>Chu, Chunqin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of dexmedetomidine on lung in rats with one-lung ventilation</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>17</volume><issue>1</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract><![CDATA[Protective effect of dexmedetomidine (DEX) on the lungs of one-lung ventilation (OLV) rat model and its effect on inflammatory factors were investigated. Ninety-two rats were selected and divided into groups A, B, C and D (n=23) according to the principle of similar body weight. OLV rat model was established. Before modeling (15 min), rats in group C were injected with sodium chloride. Rats in group D were injected with DEX at a speed of 5 µg/kg/h. Group A rats were ventilated in both lungs for 2 h. Rats in groups B and C (0.9% sodium chloride injection + OLV) and in group D (DEX + OLV) were subjected to OLV for 2 h and bilateral ventilation for 10 min. Concentrations of interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) in lung tissue of rats were detected by ELISA. The malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity in rat lung tissue were detected by radioimmunoassay. Wet weight (W)/dry weight (D) of lung tissue was calculated and indexes of the four groups of rats were compared. Compared with group A, IL-6, TNF-α and MDA concentrations and W/D of lung tissue of rats in groups B, C and D were significantly increased (p<0.05); SOD activity and IL-10 concentration were significantly decreased (p<0.01). Compared with groups B and C, the concentrations of IL-6, TNF-α and W/D in rats of group D were significantly decreased (p<0.01), but IL-10 significantly increased (p<0.01). Compared with groups B and C, the MDA concentration in lung tissue of rats in group D was significantly decreased (p<0.01), but SOD activity significantly increased (p<0.01). DEX can inhibit the production of inflammatory factors in the development and progression of pulmonary inflammation. It can inhibit lipid peroxidation, relieve pulmonary edema, and reduce lung injury after OLV, sin order to protect the lung.]]></abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30651781</pmid><doi>10.3892/etm.2018.6952</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood pressure Catheters Dexmedetomidine Dosage and administration Edema Free radicals Heart rate Humidity Hypoxia Inflammation Ischemia Laboratory animals Lipid peroxidation Lipids Lung Lungs Mechanical ventilation Methods Ostomy Pathogenesis Physiology Rodents Surgery Thoracic surgery Tumor necrosis factor-TNF Ventilation Ventilators |
| title | Protective effects of dexmedetomidine on lung in rats with one-lung ventilation |
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