Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank
Background: Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be l...
Gespeichert in:
| Veröffentlicht in: | African health sciences 2018-09, Vol.18 (3), p.496-502 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 502 |
|---|---|
| container_issue | 3 |
| container_start_page | 496 |
| container_title | African health sciences |
| container_volume | 18 |
| creator | Chirambo-Kalolekesha, Memory Kaile, Trevor Mwaba, Florence Daka, Victor Simakando, Marah Kowa, Sumbukeni |
| description | Background: Human Parvovirus (B19V) is a small, single-stranded,
non-enveloped DNA virus which is pathogenic to humans causing a wide
array of clinical complications which include erythema infectiosum,
aplastic crisis and hydrops foetalis. It is generally harmless in
healthy individuals but may be life threatening in immunocompromised
individuals such as patients with sickle cell disease, cancer, HIV and
pregnant women. It has been shown to be transmissible by blood
transfusion but donor screening for the virus is not yet mandatory in
most sub-Saharan African countries including Zambia. Materials and
methods: This was a cross-sectional study undertaken at the Kitwe
Central Hospital, blood bank and Tropical Diseases Research Centre at
Ndola Central Hospital. A total of 192 blood samples were screened for
Ig M antibodies against parvovirus B19 by ELISA. Objectives: The
general objective of the study was to determine the seroprevalence of
parvovirus B19 infections among healthy blood donors at the Kitwe
Central Hospital blood bank. Specific Objectives were to detect
parvovirus B19 Ig M antibodies in donor blood using serology and to
analyse the age and sex distribution of parvovirus among blood donors.
Results: The prevalence of parvovirus B19 Ig M in this study was 15.6%.
The majority of the positive cases were in the age group 15-22 years
(17.8%) but there was no statistical significance between occurrence of
parvovirus and age ( p value=0.703). Prevalence in males was higher
than in females that is 16.4% and 13.8%, respectively. The relationship
between gender and parvovirus B19 occurrence was however not
significant either (p value=0.516) Conclusion: This study showed a
15.6% prevalence rate of acute Parvovirus B19 infections in blood
donors at the Kitwe Central Hospital, blood bank. Studies with larger
sample sizes are needed to validate these results. |
| doi_str_mv | 10.4314/ahs.v18i3.5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6307010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2163015641</sourcerecordid><originalsourceid>FETCH-LOGICAL-b383t-89acae20371e7b439aa854b29bfc8913276a4b38b455113477cf8256847ef8a3</originalsourceid><addsrcrecordid>eNpVkU9v1DAQxSMEoqVw4o58RIJs7dhJHA6VyvJnV1Ti0IoDF2ucnTSmWTvYSRBfiU-J02xXcJrRzO-9GeklyUtGV4IzcQ5tWE1MGr7KHyWnrMyqlOaUP459IWlaVDQ_SZ6F8IPSrGAVe5qccFrQrJL0NPlzjd71Hifo0NZIXEN68JObjB8Dec8qYizRnXM7snPW-fCODC0Sb8JdIGB3pG6hi9JbDLN2IQcPNjRjMM7O8u-w1wbmbpaih5ncbL-dX24_XBMY7sdfzPALyRptFHdk40JvBujeHhw12LvnyZMGuoAvDvUsufn08Wa9Sa--ft6uL69SzSUfUllBDZhRXjIsteAVgMyFzird1LJiPCsLEBHVIs8Z46Is60ZmeSFFiY0EfpZcLLb9qPe4q5ePVO_NHvxv5cCo_zfWtOrWTargtKSMRoPXBwPvfo4YBrU3ocauA4tuDCpjkWR5IVhE3yxo7V0IHpvjGUbVHK6K4ar7cFUe6Vf_fnZkH9KMwGoBtHGdsXgkam9APQyjYxuYpIXgfwH4cbOV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2163015641</pqid></control><display><type>article</type><title>Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank</title><source>African Journals Online (Open Access)</source><source>MEDLINE</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chirambo-Kalolekesha, Memory ; Kaile, Trevor ; Mwaba, Florence ; Daka, Victor ; Simakando, Marah ; Kowa, Sumbukeni</creator><creatorcontrib>Chirambo-Kalolekesha, Memory ; Kaile, Trevor ; Mwaba, Florence ; Daka, Victor ; Simakando, Marah ; Kowa, Sumbukeni</creatorcontrib><description>Background: Human Parvovirus (B19V) is a small, single-stranded,
non-enveloped DNA virus which is pathogenic to humans causing a wide
array of clinical complications which include erythema infectiosum,
aplastic crisis and hydrops foetalis. It is generally harmless in
healthy individuals but may be life threatening in immunocompromised
individuals such as patients with sickle cell disease, cancer, HIV and
pregnant women. It has been shown to be transmissible by blood
transfusion but donor screening for the virus is not yet mandatory in
most sub-Saharan African countries including Zambia. Materials and
methods: This was a cross-sectional study undertaken at the Kitwe
Central Hospital, blood bank and Tropical Diseases Research Centre at
Ndola Central Hospital. A total of 192 blood samples were screened for
Ig M antibodies against parvovirus B19 by ELISA. Objectives: The
general objective of the study was to determine the seroprevalence of
parvovirus B19 infections among healthy blood donors at the Kitwe
Central Hospital blood bank. Specific Objectives were to detect
parvovirus B19 Ig M antibodies in donor blood using serology and to
analyse the age and sex distribution of parvovirus among blood donors.
Results: The prevalence of parvovirus B19 Ig M in this study was 15.6%.
The majority of the positive cases were in the age group 15-22 years
(17.8%) but there was no statistical significance between occurrence of
parvovirus and age ( p value=0.703). Prevalence in males was higher
than in females that is 16.4% and 13.8%, respectively. The relationship
between gender and parvovirus B19 occurrence was however not
significant either (p value=0.516) Conclusion: This study showed a
15.6% prevalence rate of acute Parvovirus B19 infections in blood
donors at the Kitwe Central Hospital, blood bank. Studies with larger
sample sizes are needed to validate these results.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v18i3.5</identifier><identifier>PMID: 30602980</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Adult ; Antibodies, Viral - blood ; blood bank ; Blood Banks ; Blood Donors ; Blood Transfusion ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV/AIDS ; Humans ; Immunoglobulin M - blood ; Kitwe Central Hospital ; Male ; Middle Aged ; Parvoviridae Infections - epidemiology ; Parvovirus B19 in blood donors ; Parvovirus B19, Human - immunology ; Seroepidemiologic Studies ; Zambia ; Zambia - epidemiology</subject><ispartof>African health sciences, 2018-09, Vol.18 (3), p.496-502</ispartof><rights>Copyright 2018 - Chirambo-Kalolekesha et al.</rights><rights>2018 Chirambo-Kalolekesha et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b383t-89acae20371e7b439aa854b29bfc8913276a4b38b455113477cf8256847ef8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307010/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307010/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768,79168</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30602980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chirambo-Kalolekesha, Memory</creatorcontrib><creatorcontrib>Kaile, Trevor</creatorcontrib><creatorcontrib>Mwaba, Florence</creatorcontrib><creatorcontrib>Daka, Victor</creatorcontrib><creatorcontrib>Simakando, Marah</creatorcontrib><creatorcontrib>Kowa, Sumbukeni</creatorcontrib><title>Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: Human Parvovirus (B19V) is a small, single-stranded,
non-enveloped DNA virus which is pathogenic to humans causing a wide
array of clinical complications which include erythema infectiosum,
aplastic crisis and hydrops foetalis. It is generally harmless in
healthy individuals but may be life threatening in immunocompromised
individuals such as patients with sickle cell disease, cancer, HIV and
pregnant women. It has been shown to be transmissible by blood
transfusion but donor screening for the virus is not yet mandatory in
most sub-Saharan African countries including Zambia. Materials and
methods: This was a cross-sectional study undertaken at the Kitwe
Central Hospital, blood bank and Tropical Diseases Research Centre at
Ndola Central Hospital. A total of 192 blood samples were screened for
Ig M antibodies against parvovirus B19 by ELISA. Objectives: The
general objective of the study was to determine the seroprevalence of
parvovirus B19 infections among healthy blood donors at the Kitwe
Central Hospital blood bank. Specific Objectives were to detect
parvovirus B19 Ig M antibodies in donor blood using serology and to
analyse the age and sex distribution of parvovirus among blood donors.
Results: The prevalence of parvovirus B19 Ig M in this study was 15.6%.
The majority of the positive cases were in the age group 15-22 years
(17.8%) but there was no statistical significance between occurrence of
parvovirus and age ( p value=0.703). Prevalence in males was higher
than in females that is 16.4% and 13.8%, respectively. The relationship
between gender and parvovirus B19 occurrence was however not
significant either (p value=0.516) Conclusion: This study showed a
15.6% prevalence rate of acute Parvovirus B19 infections in blood
donors at the Kitwe Central Hospital, blood bank. Studies with larger
sample sizes are needed to validate these results.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>blood bank</subject><subject>Blood Banks</subject><subject>Blood Donors</subject><subject>Blood Transfusion</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>HIV/AIDS</subject><subject>Humans</subject><subject>Immunoglobulin M - blood</subject><subject>Kitwe Central Hospital</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parvoviridae Infections - epidemiology</subject><subject>Parvovirus B19 in blood donors</subject><subject>Parvovirus B19, Human - immunology</subject><subject>Seroepidemiologic Studies</subject><subject>Zambia</subject><subject>Zambia - epidemiology</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNpVkU9v1DAQxSMEoqVw4o58RIJs7dhJHA6VyvJnV1Ti0IoDF2ucnTSmWTvYSRBfiU-J02xXcJrRzO-9GeklyUtGV4IzcQ5tWE1MGr7KHyWnrMyqlOaUP459IWlaVDQ_SZ6F8IPSrGAVe5qccFrQrJL0NPlzjd71Hifo0NZIXEN68JObjB8Dec8qYizRnXM7snPW-fCODC0Sb8JdIGB3pG6hi9JbDLN2IQcPNjRjMM7O8u-w1wbmbpaih5ncbL-dX24_XBMY7sdfzPALyRptFHdk40JvBujeHhw12LvnyZMGuoAvDvUsufn08Wa9Sa--ft6uL69SzSUfUllBDZhRXjIsteAVgMyFzird1LJiPCsLEBHVIs8Z46Is60ZmeSFFiY0EfpZcLLb9qPe4q5ePVO_NHvxv5cCo_zfWtOrWTargtKSMRoPXBwPvfo4YBrU3ocauA4tuDCpjkWR5IVhE3yxo7V0IHpvjGUbVHK6K4ar7cFUe6Vf_fnZkH9KMwGoBtHGdsXgkam9APQyjYxuYpIXgfwH4cbOV</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Chirambo-Kalolekesha, Memory</creator><creator>Kaile, Trevor</creator><creator>Mwaba, Florence</creator><creator>Daka, Victor</creator><creator>Simakando, Marah</creator><creator>Kowa, Sumbukeni</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank</title><author>Chirambo-Kalolekesha, Memory ; Kaile, Trevor ; Mwaba, Florence ; Daka, Victor ; Simakando, Marah ; Kowa, Sumbukeni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b383t-89acae20371e7b439aa854b29bfc8913276a4b38b455113477cf8256847ef8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>blood bank</topic><topic>Blood Banks</topic><topic>Blood Donors</topic><topic>Blood Transfusion</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>HIV/AIDS</topic><topic>Humans</topic><topic>Immunoglobulin M - blood</topic><topic>Kitwe Central Hospital</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parvoviridae Infections - epidemiology</topic><topic>Parvovirus B19 in blood donors</topic><topic>Parvovirus B19, Human - immunology</topic><topic>Seroepidemiologic Studies</topic><topic>Zambia</topic><topic>Zambia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chirambo-Kalolekesha, Memory</creatorcontrib><creatorcontrib>Kaile, Trevor</creatorcontrib><creatorcontrib>Mwaba, Florence</creatorcontrib><creatorcontrib>Daka, Victor</creatorcontrib><creatorcontrib>Simakando, Marah</creatorcontrib><creatorcontrib>Kowa, Sumbukeni</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chirambo-Kalolekesha, Memory</au><au>Kaile, Trevor</au><au>Mwaba, Florence</au><au>Daka, Victor</au><au>Simakando, Marah</au><au>Kowa, Sumbukeni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>18</volume><issue>3</issue><spage>496</spage><epage>502</epage><pages>496-502</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Background: Human Parvovirus (B19V) is a small, single-stranded,
non-enveloped DNA virus which is pathogenic to humans causing a wide
array of clinical complications which include erythema infectiosum,
aplastic crisis and hydrops foetalis. It is generally harmless in
healthy individuals but may be life threatening in immunocompromised
individuals such as patients with sickle cell disease, cancer, HIV and
pregnant women. It has been shown to be transmissible by blood
transfusion but donor screening for the virus is not yet mandatory in
most sub-Saharan African countries including Zambia. Materials and
methods: This was a cross-sectional study undertaken at the Kitwe
Central Hospital, blood bank and Tropical Diseases Research Centre at
Ndola Central Hospital. A total of 192 blood samples were screened for
Ig M antibodies against parvovirus B19 by ELISA. Objectives: The
general objective of the study was to determine the seroprevalence of
parvovirus B19 infections among healthy blood donors at the Kitwe
Central Hospital blood bank. Specific Objectives were to detect
parvovirus B19 Ig M antibodies in donor blood using serology and to
analyse the age and sex distribution of parvovirus among blood donors.
Results: The prevalence of parvovirus B19 Ig M in this study was 15.6%.
The majority of the positive cases were in the age group 15-22 years
(17.8%) but there was no statistical significance between occurrence of
parvovirus and age ( p value=0.703). Prevalence in males was higher
than in females that is 16.4% and 13.8%, respectively. The relationship
between gender and parvovirus B19 occurrence was however not
significant either (p value=0.516) Conclusion: This study showed a
15.6% prevalence rate of acute Parvovirus B19 infections in blood
donors at the Kitwe Central Hospital, blood bank. Studies with larger
sample sizes are needed to validate these results.</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>30602980</pmid><doi>10.4314/ahs.v18i3.5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1680-6905 |
| ispartof | African health sciences, 2018-09, Vol.18 (3), p.496-502 |
| issn | 1680-6905 1729-0503 1680-6905 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6307010 |
| source | African Journals Online (Open Access); MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Antibodies, Viral - blood blood bank Blood Banks Blood Donors Blood Transfusion Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female HIV/AIDS Humans Immunoglobulin M - blood Kitwe Central Hospital Male Middle Aged Parvoviridae Infections - epidemiology Parvovirus B19 in blood donors Parvovirus B19, Human - immunology Seroepidemiologic Studies Zambia Zambia - epidemiology |
| title | Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T09%3A55%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Seroprevalence%20of%20parvovirus%20B19%20in%20blood%20donors:%20the%20risks%20and%20challenges%20of%20blood%20transfusion%20in%20Zambia%20in%20the%20era%20of%20HIV/AIDS%20at%20the%20Kitwe%20Central%20Hospital,%20blood%20bank&rft.jtitle=African%20health%20sciences&rft.au=Chirambo-Kalolekesha,%20Memory&rft.date=2018-09-01&rft.volume=18&rft.issue=3&rft.spage=496&rft.epage=502&rft.pages=496-502&rft.issn=1680-6905&rft.eissn=1729-0503&rft_id=info:doi/10.4314/ahs.v18i3.5&rft_dat=%3Cproquest_pubme%3E2163015641%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2163015641&rft_id=info:pmid/30602980&rfr_iscdi=true |