Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs
Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored t...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2018, Vol.80(12), pp.1818-1821 |
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| container_issue | 12 |
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| container_title | Journal of Veterinary Medical Science |
| container_volume | 80 |
| creator | SHIWA, Nozomi NAKAJIMA, Chikage KIMITSUKI, Kazunori MANALO, Daria Llenaresas NOGUCHI, Akira INOUE, Satoshi PARK, Chun-Ho |
| description | Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies. |
| doi_str_mv | 10.1292/jvms.18-0519 |
| format | Article |
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These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.18-0519</identifier><identifier>PMID: 30333382</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Antigens ; Cytoplasm ; follicle-sinus complex (FSC) ; Genomes ; Merkel cell ; Pathology ; post-mortem diagnosis ; rabid dog ; Rabies ; Ribonucleic acid ; RNA ; Sensitivity ; Skin ; Viruses</subject><ispartof>Journal of Veterinary Medical Science, 2018, Vol.80(12), pp.1818-1821</ispartof><rights>2018 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency Dec 2018</rights><rights>2018 The Japanese Society of Veterinary Science 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-45f42d2550cb573e072bc94e5ace7885e227ea9c9227bcab90c93c99f798baea3</citedby><cites>FETCH-LOGICAL-c619t-45f42d2550cb573e072bc94e5ace7885e227ea9c9227bcab90c93c99f798baea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305517/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305517/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIWA, Nozomi</creatorcontrib><creatorcontrib>NAKAJIMA, Chikage</creatorcontrib><creatorcontrib>KIMITSUKI, Kazunori</creatorcontrib><creatorcontrib>MANALO, Daria Llenaresas</creatorcontrib><creatorcontrib>NOGUCHI, Akira</creatorcontrib><creatorcontrib>INOUE, Satoshi</creatorcontrib><creatorcontrib>PARK, Chun-Ho</creatorcontrib><title>Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.</description><subject>Antigens</subject><subject>Cytoplasm</subject><subject>follicle-sinus complex (FSC)</subject><subject>Genomes</subject><subject>Merkel cell</subject><subject>Pathology</subject><subject>post-mortem diagnosis</subject><subject>rabid dog</subject><subject>Rabies</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sensitivity</subject><subject>Skin</subject><subject>Viruses</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkc-L1DAUx4Mo7rh68ywBLyvYNT-aprkIMjgqLHhQr4Y0fZ3NmDRj0i66f72pXQc1h7yE9-HDe3wRekrJJWWKvTrchHxJ24oIqu6hDeW1rGTN1X20IYo2lWSCnKFHOR8IYbRu1EN0xgkvp2Ub9HUXvXfWA85unDO2MRw9_ICML3aftvkFdiMO8-3tAnwrb5PxMeYpxDRBwL0z-7F8ncXBTJCc8TgOOJnO9biP-_wYPRiMz_Dkrp6jL7u3n7fvq6uP7z5s31xVtqFqqmox1KxnQhDbCcmBSNZZVYMwFmTbCmBMglFWldpZ0yliFbdKDVK1nQHDz9Hr1XucuwC9hXFKxutjcsGknzoap__tjO5a7-ONbjgRgsoiuLgTpPh9hjzp4LIF780Icc6aUcaEaoioC_r8P_QQ5zSW9TRjXDWsbuRCvVwpm2LOCYbTMJToJTi9BKdpq5fgCv7s7wVO8J-kCrBdgUOezB5OgEnTEt9qaxf173vVnrr22iQNI_8F9met0A</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>SHIWA, Nozomi</creator><creator>NAKAJIMA, Chikage</creator><creator>KIMITSUKI, Kazunori</creator><creator>MANALO, Daria Llenaresas</creator><creator>NOGUCHI, Akira</creator><creator>INOUE, Satoshi</creator><creator>PARK, Chun-Ho</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs</title><author>SHIWA, Nozomi ; NAKAJIMA, Chikage ; KIMITSUKI, Kazunori ; MANALO, Daria Llenaresas ; NOGUCHI, Akira ; INOUE, Satoshi ; PARK, Chun-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-45f42d2550cb573e072bc94e5ace7885e227ea9c9227bcab90c93c99f798baea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antigens</topic><topic>Cytoplasm</topic><topic>follicle-sinus complex (FSC)</topic><topic>Genomes</topic><topic>Merkel cell</topic><topic>Pathology</topic><topic>post-mortem diagnosis</topic><topic>rabid dog</topic><topic>Rabies</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Sensitivity</topic><topic>Skin</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIWA, Nozomi</creatorcontrib><creatorcontrib>NAKAJIMA, Chikage</creatorcontrib><creatorcontrib>KIMITSUKI, Kazunori</creatorcontrib><creatorcontrib>MANALO, Daria Llenaresas</creatorcontrib><creatorcontrib>NOGUCHI, Akira</creatorcontrib><creatorcontrib>INOUE, Satoshi</creatorcontrib><creatorcontrib>PARK, Chun-Ho</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIWA, Nozomi</au><au>NAKAJIMA, Chikage</au><au>KIMITSUKI, Kazunori</au><au>MANALO, Daria Llenaresas</au><au>NOGUCHI, Akira</au><au>INOUE, Satoshi</au><au>PARK, Chun-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>80</volume><issue>12</issue><spage>1818</spage><epage>1821</epage><pages>1818-1821</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). 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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Antigens Cytoplasm follicle-sinus complex (FSC) Genomes Merkel cell Pathology post-mortem diagnosis rabid dog Rabies Ribonucleic acid RNA Sensitivity Skin Viruses |
| title | Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs |
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