Structure and activity of lipid bilayer within a membrane-protein transporter

Membrane proteins function in native cell membranes, but extraction into isolated particles is needed for many biochemical and structural analyses. Commonly used detergent-extraction methods destroy naturally associated lipid bilayers. Here, we devised a detergent-free method for preparing cell-memb...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-12, Vol.115 (51), p.12985-12990
Hauptverfasser:	Qiu, Weihua, Fu, Ziao, Xu, Guoyan G., Grassucci, Robert A., Zhang, Yan, Frank, Joachim, Hendrickson, Wayne A., Guo, Youzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Buttresses Cell Membrane - chemistry Cell Membrane - metabolism Cell membranes Chains Crystal structure Crystallography, X-Ray Detergents - chemistry Detergents - metabolism Domains Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Lipid bilayers Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipids Membrane proteins Membranes Multidrug Resistance-Associated Proteins - chemistry Multidrug Resistance-Associated Proteins - metabolism Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Protein Conformation Protein interaction Protein transport Proteins Solubilization Transmembrane domains Trimers Visualization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!