Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories

The rotavirus (RV) genome is replicated and packaged into virus progeny in cytoplasmic inclusions called viroplasms, which require interactions between RV nonstructural proteins NSP2 and NSP5. How viroplasms form remains unknown. We previously found two forms of NSP2 in RV-infected cells: a cytoplas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-12, Vol.115 (51), p.E12015-E12023
Hauptverfasser:	Criglar, Jeanette M., Anish, Ramakrishnan, Hu, Liya, Crawford, Sue E., Sankaran, Banumathi, Prasad, B. V. Venkataram, Estes, Mary K.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Biological Sciences Cells CK1α Crystallography Cytoplasm Dispersion Genomes Inclusion bodies Kinases Mass spectrometry Mass spectroscopy Nonstructural proteins Phosphorylation PNAS Plus Progeny Proteins Replication Ribonucleic acid RNA RNA viruses Rotavirus Serine Viroplasm viroplasm NSP2 virus factory Viruses
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