A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate–prednisone

Genomic aberrations have been identified in metastatic castration-resistant prostate cancer (mCRPC), but molecular predictors of resistance to abiraterone acetate/prednisone (AA/P) treatment are not known. In a prospective clinical trial, mCRPC patients underwent whole-exome sequencing (n = 82) and...

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Veröffentlicht in:	Annals of oncology 2018-02, Vol.29 (2), p.352-360
Hauptverfasser:	Wang, L., Dehm, S.M., Hillman, D.W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B.A., Pitot, H.C., Ho, T., Bryce, A.H., Ye, Z., Li, Y., Eiken, P., Vedell, P.T., Barman, P., McMenomy, B.P., Atwell, T.D., Carlson, R.E., Ellingson, M., Eckloff, B.W., Qin, R., Ou, F., Hart, S.N., Huang, H., Jen, J., Wieben, E.D., Kalari, K.R., Weinshilboum, R.M., Kohli, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	abiraterone acetate Abiraterone Acetate - administration & dosage Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use castrate-resistance prostate cancer Cell Cycle Cell Proliferation Drug Resistance, Neoplasm - genetics Genome-Wide Association Study Humans Male Middle Aged Neoplasm Metastasis - drug therapy Neoplasm Metastasis - genetics Original Prednisone - administration & dosage Prospective Studies Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Wnt Signaling Pathway - genetics Wnt/ß-catenin signaling
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