Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study
ObjectivesWithin the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour...
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| creator | Osman, Wael M Jelinek, Herbert F Tay, Guan K Khandoker, Ahsan H Khalaf, Kinda Almahmeed, Wael Hassan, Mohamed H Alsafar, Habiba S |
| description | ObjectivesWithin the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD). Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea.ResultsPatients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia. Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=0.02, OR=3.12, 95% CI 1.21 to 8.02). Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (Padjusted=0.04, OR=1.46); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels.ConclusionsAssociations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry. |
| doi_str_mv | 10.1136/bmjopen-2017-020759 |
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The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD). Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea.ResultsPatients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia. Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=0.02, OR=3.12, 95% CI 1.21 to 8.02). Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (Padjusted=0.04, OR=1.46); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels.ConclusionsAssociations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2017-020759</identifier><identifier>PMID: 30552240</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age ; Aged ; Biomarkers ; Cluster Analysis ; Cross-Sectional Studies ; Diabetes ; Diabetes and Endocrinology ; Diabetic Nephropathies - diagnosis ; Diabetic Nephropathies - genetics ; Diabetic nephropathy ; Female ; Gender ; Gene loci ; Genetic Association Studies ; Genetic Loci ; Genetic Markers - genetics ; Genetic Predisposition to Disease - genetics ; Genomes ; Humans ; Kidney diseases ; Kidney Function Tests ; Laboratories ; Male ; Middle Aged ; Mortality ; Population ; Risk Factors ; United Arab Emirates ; Vitamin D</subject><ispartof>BMJ open, 2018-12, Vol.8 (12), p.e020759-e020759</ispartof><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2018 Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-f49b6aab6d9366a44433f7d4236b1d55831bd5bc3102dbdc3d7d3493e93a0b8b3</citedby><cites>FETCH-LOGICAL-b472t-f49b6aab6d9366a44433f7d4236b1d55831bd5bc3102dbdc3d7d3493e93a0b8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/8/12/e020759.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/8/12/e020759.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27549,27550,27924,27925,53791,53793,77601,77632</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30552240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osman, Wael M</creatorcontrib><creatorcontrib>Jelinek, Herbert F</creatorcontrib><creatorcontrib>Tay, Guan K</creatorcontrib><creatorcontrib>Khandoker, Ahsan H</creatorcontrib><creatorcontrib>Khalaf, Kinda</creatorcontrib><creatorcontrib>Almahmeed, Wael</creatorcontrib><creatorcontrib>Hassan, Mohamed H</creatorcontrib><creatorcontrib>Alsafar, Habiba S</creatorcontrib><title>Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesWithin the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD). Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea.ResultsPatients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia. Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=0.02, OR=3.12, 95% CI 1.21 to 8.02). Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (Padjusted=0.04, OR=1.46); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels.ConclusionsAssociations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Cluster Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes and Endocrinology</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic nephropathy</subject><subject>Female</subject><subject>Gender</subject><subject>Gene loci</subject><subject>Genetic Association Studies</subject><subject>Genetic Loci</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genomes</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Function Tests</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Population</subject><subject>Risk Factors</subject><subject>United Arab Emirates</subject><subject>Vitamin D</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9rFDEYxoMottR-AkECXrxMzf_Z8SCUpdpCwYs9h2TyTpt1JlmTTGHvfnCzs2upnswled_8noe8eRB6S8kFpVx9tNMmbiE0jNC2IYy0snuBThkRolFEypfPzifoPOcNqUvITkr2Gp3w2mZMkFP0az364HszYhMcvocAxffY5Bx7b4qPIeM44AShEsMc-n1rQZ03dmF_eBdgV-sMJgP2AZcHwHfBF3D4MhmLryafTIH8CRvcp5hzk2Exqp65zG73Br0azJjh_LifobsvV9_X183tt68368vbxoqWlWYQnVXGWOU6rpQRQnA-tE4wrix1Uq44tU7anlPCnHU9d63jouPQcUPsyvIz9Pngu53tBK6HUJIZ9Tb5yaSdjsbrv2-Cf9D38VErTriishp8OBqk-HOGXPTkcw_jaALEOWtGZauUXLVdRd__g27inOrIC6XaThHSVoofqOVfEgxPj6FE74PWx6D1Pmh9CLqq3j2f40nzJ9YKXByAqv4vx99pt7aQ</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Osman, Wael M</creator><creator>Jelinek, Herbert F</creator><creator>Tay, Guan K</creator><creator>Khandoker, Ahsan H</creator><creator>Khalaf, Kinda</creator><creator>Almahmeed, Wael</creator><creator>Hassan, Mohamed H</creator><creator>Alsafar, Habiba S</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study</title><author>Osman, Wael M ; Jelinek, Herbert F ; Tay, Guan K ; Khandoker, Ahsan H ; Khalaf, Kinda ; Almahmeed, Wael ; Hassan, Mohamed H ; Alsafar, Habiba S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-f49b6aab6d9366a44433f7d4236b1d55831bd5bc3102dbdc3d7d3493e93a0b8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Cluster Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes and Endocrinology</topic><topic>Diabetic Nephropathies - diagnosis</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic nephropathy</topic><topic>Female</topic><topic>Gender</topic><topic>Gene loci</topic><topic>Genetic Association Studies</topic><topic>Genetic Loci</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genomes</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Function Tests</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Population</topic><topic>Risk Factors</topic><topic>United Arab Emirates</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osman, Wael M</creatorcontrib><creatorcontrib>Jelinek, Herbert F</creatorcontrib><creatorcontrib>Tay, Guan K</creatorcontrib><creatorcontrib>Khandoker, Ahsan H</creatorcontrib><creatorcontrib>Khalaf, Kinda</creatorcontrib><creatorcontrib>Almahmeed, Wael</creatorcontrib><creatorcontrib>Hassan, Mohamed H</creatorcontrib><creatorcontrib>Alsafar, Habiba S</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osman, Wael M</au><au>Jelinek, Herbert F</au><au>Tay, Guan K</au><au>Khandoker, Ahsan H</au><au>Khalaf, Kinda</au><au>Almahmeed, Wael</au><au>Hassan, Mohamed H</au><au>Alsafar, Habiba S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>8</volume><issue>12</issue><spage>e020759</spage><epage>e020759</epage><pages>e020759-e020759</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesWithin the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD). Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea.ResultsPatients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia. Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=0.02, OR=3.12, 95% CI 1.21 to 8.02). Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (Padjusted=0.04, OR=1.46); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels.ConclusionsAssociations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30552240</pmid><doi>10.1136/bmjopen-2017-020759</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Biomarkers Cluster Analysis Cross-Sectional Studies Diabetes Diabetes and Endocrinology Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic nephropathy Female Gender Gene loci Genetic Association Studies Genetic Loci Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genomes Humans Kidney diseases Kidney Function Tests Laboratories Male Middle Aged Mortality Population Risk Factors United Arab Emirates Vitamin D |
| title | Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study |
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