Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria
Compositional asymmetry between the leaflets of bilayer membranes modifies their phase behavior and is thought to influence other important features such as mechanical properties and protein activity. We address here how phase behavior is affected by passive phospholipid flip-flop, such that the com...
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| Veröffentlicht in: | Biophysical journal 2018-11, Vol.115 (10), p.1956-1965 |
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| container_end_page | 1965 |
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| container_issue | 10 |
| container_start_page | 1956 |
| container_title | Biophysical journal |
| container_volume | 115 |
| creator | Williamson, John J. Olmsted, Peter D. |
| description | Compositional asymmetry between the leaflets of bilayer membranes modifies their phase behavior and is thought to influence other important features such as mechanical properties and protein activity. We address here how phase behavior is affected by passive phospholipid flip-flop, such that the compositional asymmetry is not fixed. We predict transitions from “pre-flip-flop” behavior to a restricted set of phase equilibria that can persist in the presence of passive flip-flop. Surprisingly, such states are not necessarily symmetric. We further account for external symmetry breaking, such as a preferential substrate interaction, and show how this can stabilize strongly asymmetric equilibrium states. Our theory explains several experimental observations of flip-flop-mediated changes in phase behavior and shows how domain formation and compositional asymmetry can be controlled in concert, by manipulating passive flip-flop rates and applying external fields. |
| doi_str_mv | 10.1016/j.bpj.2018.10.003 |
| format | Article |
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| ispartof | Biophysical journal, 2018-11, Vol.115 (10), p.1956-1965 |
| issn | 0006-3495 1542-0086 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); PubMed Central |
| subjects | Kinetics Lipid Bilayers - chemistry Membranes Phospholipids - chemistry Thermodynamics |
| title | Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria |
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