Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke
Objective The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome...
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| Veröffentlicht in: | European radiology 2019-02, Vol.29 (2), p.736-744 |
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| creator | Compagne, K. C. J. Boers, A. M. M. Marquering, H. A. Berkhemer, O. A. Yoo, A. J. Beenen, L. F. M. van Oostenbrugge, R. J. van Zwam, W.H. Roos, Y. B. W. E. M. Majoie, C. B. van Es, A. C. G. M. van der Lugt, A. Dippel, D. W. J. Lingsma, H. |
| description | Objective
The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome in a randomised trial of EVT versus no EVT (MR CLEAN).
Methods
FIV was assessed on non-contrast CT scan 5–7 days after stroke. Functional outcome was the score on the modified Rankin Scale at 3 months. We tested the causal pathway from intervention, via FIV to functional outcome with a mediation model, using linear and ordinal regression, adjusted for relevant baseline covariates, including stroke severity. Explained effect was assessed by taking the ratio of the log odds ratios of treatment with and without adjustment for FIV.
Results
Of the 500 patients included in MR CLEAN, 60 died and four patients underwent hemicraniectomy before FIV was assessed, leaving 436 patients for analysis. Patients in the intervention group had better functional outcomes (adjusted common odds ratio (acOR) 2.30 (95% CI 1.62–3.26) than controls and smaller FIV (median 53 vs. 81 ml) (difference 28 ml; 95% CI 13–41). Smaller FIV was associated with better outcome (acOR per 10 ml 0.60, 95% CI 0.52–0.68). After adjustment for FIV the effect of intervention on functional outcome decreased but remained substantial (acOR 2.05, 95% CI 1.44–2.91). This implies that preventing FIV progression explains 14% (95% CI 0–34) of the beneficial effect of EVT on outcome.
Conclusion
The effect of EVT on FIV explains only part of the treatment effect on functional outcome.
Key Points
• Endovascular treatment in acute ischaemic stroke patients prevents progression of follow-up infarct volume on non-contrast CT at 5
–
7 days.
• Follow-up infarct volume was related to functional outcome, but only explained a modest part of the effect of intervention on functional outcome.
• A large proportion of treatment effect on functional outcome remains unexplained, suggesting FIV alone cannot be used as an early surrogate imaging marker of functional outcome. |
| doi_str_mv | 10.1007/s00330-018-5578-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6302877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2066870170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3a05c115393b4915c98e965110c2e17c8b70a31aba3a2857f5215008562219453</originalsourceid><addsrcrecordid>eNp1kc1uFDEQhC0EIkvgAbggS1y4DHTb47F9QUIRAaRIXOBs9TqeZMKMvbE9G_H2OGwIPxInH_qr6i4XY88RXiOAflMApIQO0HRKadPZB2yDvRQdgukfsg1YaTptbX_EnpRyBQAWe_2YHQlrje4Fbtj1aZrndNOtOz7FkbKvfJ_mdQmcCie-hPOJaso8jTzE87Sn4teZMq85UF1CrDyMY2iqFPm4Rl-nFGnmaa0-NZMp8qn4SwrL5HmpOX0LT9mjkeYSnt29x-zr6fsvJx-7s88fPp28O-t8r6F2kkB5RCWt3PYWlbcm2EEhghcBtTdbDSSRtiRJGKVHJVABGDUIgbZX8pi9Pfju1m2L4dutmWa3y9NC-btLNLm_J3G6dBdp7wYJwmjdDF7dGeR0vYZS3dKyhHmmGNJanIBBm7ZZioa-_Ae9SmtuH_GTGowG1NAoPFA-p1JyGO-PQXC3hbpDoa4V6m4LdbZpXvyZ4l7xq8EGiANQ2ihehPx79f9dfwCmw6wZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2066870170</pqid></control><display><type>article</type><title>Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Compagne, K. C. J. ; Boers, A. M. M. ; Marquering, H. A. ; Berkhemer, O. A. ; Yoo, A. J. ; Beenen, L. F. M. ; van Oostenbrugge, R. J. ; van Zwam, W.H. ; Roos, Y. B. W. E. M. ; Majoie, C. B. ; van Es, A. C. G. M. ; van der Lugt, A. ; Dippel, D. W. J. ; Lingsma, H.</creator><creatorcontrib>Compagne, K. C. J. ; Boers, A. M. M. ; Marquering, H. A. ; Berkhemer, O. A. ; Yoo, A. J. ; Beenen, L. F. M. ; van Oostenbrugge, R. J. ; van Zwam, W.H. ; Roos, Y. B. W. E. M. ; Majoie, C. B. ; van Es, A. C. G. M. ; van der Lugt, A. ; Dippel, D. W. J. ; Lingsma, H. ; MR CLEAN Investigators ; for the MR CLEAN Investigators</creatorcontrib><description>Objective
The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome in a randomised trial of EVT versus no EVT (MR CLEAN).
Methods
FIV was assessed on non-contrast CT scan 5–7 days after stroke. Functional outcome was the score on the modified Rankin Scale at 3 months. We tested the causal pathway from intervention, via FIV to functional outcome with a mediation model, using linear and ordinal regression, adjusted for relevant baseline covariates, including stroke severity. Explained effect was assessed by taking the ratio of the log odds ratios of treatment with and without adjustment for FIV.
Results
Of the 500 patients included in MR CLEAN, 60 died and four patients underwent hemicraniectomy before FIV was assessed, leaving 436 patients for analysis. Patients in the intervention group had better functional outcomes (adjusted common odds ratio (acOR) 2.30 (95% CI 1.62–3.26) than controls and smaller FIV (median 53 vs. 81 ml) (difference 28 ml; 95% CI 13–41). Smaller FIV was associated with better outcome (acOR per 10 ml 0.60, 95% CI 0.52–0.68). After adjustment for FIV the effect of intervention on functional outcome decreased but remained substantial (acOR 2.05, 95% CI 1.44–2.91). This implies that preventing FIV progression explains 14% (95% CI 0–34) of the beneficial effect of EVT on outcome.
Conclusion
The effect of EVT on FIV explains only part of the treatment effect on functional outcome.
Key Points
• Endovascular treatment in acute ischaemic stroke patients prevents progression of follow-up infarct volume on non-contrast CT at 5
–
7 days.
• Follow-up infarct volume was related to functional outcome, but only explained a modest part of the effect of intervention on functional outcome.
• A large proportion of treatment effect on functional outcome remains unexplained, suggesting FIV alone cannot be used as an early surrogate imaging marker of functional outcome.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-018-5578-9</identifier><identifier>PMID: 29987421</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Brain - diagnostic imaging ; Brain Ischemia - diagnosis ; Brain Ischemia - surgery ; Cardiovascular system ; Causality ; Computed tomography ; Diagnostic Radiology ; Endovascular Procedures - methods ; Female ; Follow-Up Studies ; Humans ; Imaging ; Internal Medicine ; Intervention ; Interventional Radiology ; Knee ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuro ; Neuroradiology ; Patients ; Radiology ; Regression analysis ; Severity of Illness Index ; Stroke ; Thrombectomy - methods ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Ultrasound</subject><ispartof>European radiology, 2019-02, Vol.29 (2), p.736-744</ispartof><rights>The Author(s) 2018</rights><rights>European Radiology is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3a05c115393b4915c98e965110c2e17c8b70a31aba3a2857f5215008562219453</citedby><cites>FETCH-LOGICAL-c470t-3a05c115393b4915c98e965110c2e17c8b70a31aba3a2857f5215008562219453</cites><orcidid>0000-0003-0608-835X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-018-5578-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-018-5578-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29987421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Compagne, K. C. J.</creatorcontrib><creatorcontrib>Boers, A. M. M.</creatorcontrib><creatorcontrib>Marquering, H. A.</creatorcontrib><creatorcontrib>Berkhemer, O. A.</creatorcontrib><creatorcontrib>Yoo, A. J.</creatorcontrib><creatorcontrib>Beenen, L. F. M.</creatorcontrib><creatorcontrib>van Oostenbrugge, R. J.</creatorcontrib><creatorcontrib>van Zwam, W.H.</creatorcontrib><creatorcontrib>Roos, Y. B. W. E. M.</creatorcontrib><creatorcontrib>Majoie, C. B.</creatorcontrib><creatorcontrib>van Es, A. C. G. M.</creatorcontrib><creatorcontrib>van der Lugt, A.</creatorcontrib><creatorcontrib>Dippel, D. W. J.</creatorcontrib><creatorcontrib>Lingsma, H.</creatorcontrib><creatorcontrib>MR CLEAN Investigators</creatorcontrib><creatorcontrib>for the MR CLEAN Investigators</creatorcontrib><title>Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome in a randomised trial of EVT versus no EVT (MR CLEAN).
Methods
FIV was assessed on non-contrast CT scan 5–7 days after stroke. Functional outcome was the score on the modified Rankin Scale at 3 months. We tested the causal pathway from intervention, via FIV to functional outcome with a mediation model, using linear and ordinal regression, adjusted for relevant baseline covariates, including stroke severity. Explained effect was assessed by taking the ratio of the log odds ratios of treatment with and without adjustment for FIV.
Results
Of the 500 patients included in MR CLEAN, 60 died and four patients underwent hemicraniectomy before FIV was assessed, leaving 436 patients for analysis. Patients in the intervention group had better functional outcomes (adjusted common odds ratio (acOR) 2.30 (95% CI 1.62–3.26) than controls and smaller FIV (median 53 vs. 81 ml) (difference 28 ml; 95% CI 13–41). Smaller FIV was associated with better outcome (acOR per 10 ml 0.60, 95% CI 0.52–0.68). After adjustment for FIV the effect of intervention on functional outcome decreased but remained substantial (acOR 2.05, 95% CI 1.44–2.91). This implies that preventing FIV progression explains 14% (95% CI 0–34) of the beneficial effect of EVT on outcome.
Conclusion
The effect of EVT on FIV explains only part of the treatment effect on functional outcome.
Key Points
• Endovascular treatment in acute ischaemic stroke patients prevents progression of follow-up infarct volume on non-contrast CT at 5
–
7 days.
• Follow-up infarct volume was related to functional outcome, but only explained a modest part of the effect of intervention on functional outcome.
• A large proportion of treatment effect on functional outcome remains unexplained, suggesting FIV alone cannot be used as an early surrogate imaging marker of functional outcome.</description><subject>Aged</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - surgery</subject><subject>Cardiovascular system</subject><subject>Causality</subject><subject>Computed tomography</subject><subject>Diagnostic Radiology</subject><subject>Endovascular Procedures - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Intervention</subject><subject>Interventional Radiology</subject><subject>Knee</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuro</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Severity of Illness Index</subject><subject>Stroke</subject><subject>Thrombectomy - methods</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1uFDEQhC0EIkvgAbggS1y4DHTb47F9QUIRAaRIXOBs9TqeZMKMvbE9G_H2OGwIPxInH_qr6i4XY88RXiOAflMApIQO0HRKadPZB2yDvRQdgukfsg1YaTptbX_EnpRyBQAWe_2YHQlrje4Fbtj1aZrndNOtOz7FkbKvfJ_mdQmcCie-hPOJaso8jTzE87Sn4teZMq85UF1CrDyMY2iqFPm4Rl-nFGnmaa0-NZMp8qn4SwrL5HmpOX0LT9mjkeYSnt29x-zr6fsvJx-7s88fPp28O-t8r6F2kkB5RCWt3PYWlbcm2EEhghcBtTdbDSSRtiRJGKVHJVABGDUIgbZX8pi9Pfju1m2L4dutmWa3y9NC-btLNLm_J3G6dBdp7wYJwmjdDF7dGeR0vYZS3dKyhHmmGNJanIBBm7ZZioa-_Ae9SmtuH_GTGowG1NAoPFA-p1JyGO-PQXC3hbpDoa4V6m4LdbZpXvyZ4l7xq8EGiANQ2ihehPx79f9dfwCmw6wZ</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Compagne, K. 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C. J. ; Boers, A. M. M. ; Marquering, H. A. ; Berkhemer, O. A. ; Yoo, A. J. ; Beenen, L. F. M. ; van Oostenbrugge, R. J. ; van Zwam, W.H. ; Roos, Y. B. W. E. M. ; Majoie, C. B. ; van Es, A. C. G. M. ; van der Lugt, A. ; Dippel, D. W. J. ; Lingsma, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3a05c115393b4915c98e965110c2e17c8b70a31aba3a2857f5215008562219453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - surgery</topic><topic>Cardiovascular system</topic><topic>Causality</topic><topic>Computed tomography</topic><topic>Diagnostic Radiology</topic><topic>Endovascular Procedures - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Intervention</topic><topic>Interventional Radiology</topic><topic>Knee</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuro</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Severity of Illness Index</topic><topic>Stroke</topic><topic>Thrombectomy - methods</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Compagne, K. C. J.</creatorcontrib><creatorcontrib>Boers, A. M. M.</creatorcontrib><creatorcontrib>Marquering, H. A.</creatorcontrib><creatorcontrib>Berkhemer, O. A.</creatorcontrib><creatorcontrib>Yoo, A. J.</creatorcontrib><creatorcontrib>Beenen, L. F. M.</creatorcontrib><creatorcontrib>van Oostenbrugge, R. J.</creatorcontrib><creatorcontrib>van Zwam, W.H.</creatorcontrib><creatorcontrib>Roos, Y. B. W. E. M.</creatorcontrib><creatorcontrib>Majoie, C. B.</creatorcontrib><creatorcontrib>van Es, A. C. G. M.</creatorcontrib><creatorcontrib>van der Lugt, A.</creatorcontrib><creatorcontrib>Dippel, D. W. J.</creatorcontrib><creatorcontrib>Lingsma, H.</creatorcontrib><creatorcontrib>MR CLEAN Investigators</creatorcontrib><creatorcontrib>for the MR CLEAN Investigators</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Compagne, K. C. J.</au><au>Boers, A. M. M.</au><au>Marquering, H. A.</au><au>Berkhemer, O. A.</au><au>Yoo, A. J.</au><au>Beenen, L. F. M.</au><au>van Oostenbrugge, R. J.</au><au>van Zwam, W.H.</au><au>Roos, Y. B. W. E. M.</au><au>Majoie, C. B.</au><au>van Es, A. C. G. M.</au><au>van der Lugt, A.</au><au>Dippel, D. W. J.</au><au>Lingsma, H.</au><aucorp>MR CLEAN Investigators</aucorp><aucorp>for the MR CLEAN Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>29</volume><issue>2</issue><spage>736</spage><epage>744</epage><pages>736-744</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome in a randomised trial of EVT versus no EVT (MR CLEAN).
Methods
FIV was assessed on non-contrast CT scan 5–7 days after stroke. Functional outcome was the score on the modified Rankin Scale at 3 months. We tested the causal pathway from intervention, via FIV to functional outcome with a mediation model, using linear and ordinal regression, adjusted for relevant baseline covariates, including stroke severity. Explained effect was assessed by taking the ratio of the log odds ratios of treatment with and without adjustment for FIV.
Results
Of the 500 patients included in MR CLEAN, 60 died and four patients underwent hemicraniectomy before FIV was assessed, leaving 436 patients for analysis. Patients in the intervention group had better functional outcomes (adjusted common odds ratio (acOR) 2.30 (95% CI 1.62–3.26) than controls and smaller FIV (median 53 vs. 81 ml) (difference 28 ml; 95% CI 13–41). Smaller FIV was associated with better outcome (acOR per 10 ml 0.60, 95% CI 0.52–0.68). After adjustment for FIV the effect of intervention on functional outcome decreased but remained substantial (acOR 2.05, 95% CI 1.44–2.91). This implies that preventing FIV progression explains 14% (95% CI 0–34) of the beneficial effect of EVT on outcome.
Conclusion
The effect of EVT on FIV explains only part of the treatment effect on functional outcome.
Key Points
• Endovascular treatment in acute ischaemic stroke patients prevents progression of follow-up infarct volume on non-contrast CT at 5
–
7 days.
• Follow-up infarct volume was related to functional outcome, but only explained a modest part of the effect of intervention on functional outcome.
• A large proportion of treatment effect on functional outcome remains unexplained, suggesting FIV alone cannot be used as an early surrogate imaging marker of functional outcome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29987421</pmid><doi>10.1007/s00330-018-5578-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0608-835X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2019-02, Vol.29 (2), p.736-744 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6302877 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Brain - diagnostic imaging Brain Ischemia - diagnosis Brain Ischemia - surgery Cardiovascular system Causality Computed tomography Diagnostic Radiology Endovascular Procedures - methods Female Follow-Up Studies Humans Imaging Internal Medicine Intervention Interventional Radiology Knee Male Medicine Medicine & Public Health Middle Aged Neuro Neuroradiology Patients Radiology Regression analysis Severity of Illness Index Stroke Thrombectomy - methods Tomography, X-Ray Computed - methods Treatment Outcome Ultrasound |
| title | Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A41%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Follow-up%20infarct%20volume%20as%20a%20mediator%20of%20endovascular%20treatment%20effect%20on%20functional%20outcome%20in%20ischaemic%20stroke&rft.jtitle=European%20radiology&rft.au=Compagne,%20K.%20C.%20J.&rft.aucorp=MR%20CLEAN%20Investigators&rft.date=2019-02-01&rft.volume=29&rft.issue=2&rft.spage=736&rft.epage=744&rft.pages=736-744&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-018-5578-9&rft_dat=%3Cproquest_pubme%3E2066870170%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2066870170&rft_id=info:pmid/29987421&rfr_iscdi=true |