High-throughput sequencing reveals restricted TCR Vβ usage and public TCRβ clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement in autoimmune diabetes

•Limited overlap of memory CD4+ TCRβ repertoires between PaLN and pancreas.•Public clonotypes are selected within the PaLN-memory CD4+ TCRβ repertoire.•Nasal treatment of female NOD mice with TCR-peptide B5 significantly prevents T1D.•Memory CD4+ T cells expressing TCR Vβ8.2 are involved in the prog...

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