Kappa Opioid Receptor Distribution and Function in Primary Afferents

Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show that KO...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2018-09, Vol.99 (6), p.1274-1288.e6
Hauptverfasser:	Snyder, Lindsey M., Chiang, Michael C., Loeza-Alcocer, Emanuel, Omori, Yu, Hachisuka, Junichi, Sheahan, Tayler D., Gale, Jenna R., Adelman, Peter C., Sypek, Elizabeth I., Fulton, Stephanie A., Friedman, Robert L., Wright, Margaret C., Duque, Melissa Giraldo, Lee, Yeon Sun, Hu, Zeyu, Huang, Huizhen, Cai, Xiaoyun, Meerschaert, Kimberly A., Nagarajan, Vidhya, Hirai, Toshiro, Scherrer, Gregory, Kaplan, Daniel H., Porreca, Frank, Davis, Brian M., Gold, Michael S., Koerber, H. Richard, Ross, Sarah E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Axons - physiology Calcium influx dorsal root ganglia DRG dynorphin Follicles Grants human Hypersensitivity Inflammation itch Mechanoreceptors Mice Mice, Transgenic mouse nalfurafine Narcotics Neurons Neurons - physiology Neurons, Afferent - drug effects Neurotransmission Nociceptors - drug effects Nociceptors - metabolism Opioid receptors (type kappa) Oprk1 Pain Pain - drug therapy Pain Management Peptides Polymerase chain reaction primary afferents Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - metabolism Sensory neurons Signal Transduction - physiology
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