Mast Cell Proteases Activate Astrocytes and Glia-Neurons and Release Interleukin-33 by Activating p38 and ERK1/2 MAPKs and NF-κB

Inflammatory mediators released from activated microglia, astrocytes, neurons, and mast cells mediate neuroinflammation. Parkinson’s disease (PD) is characterized by inflammation-dependent dopaminergic neurodegeneration in substantia nigra. 1-Methyl-4-phenylpyridinium (MPP + ), a metabolite of parki...

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Veröffentlicht in:	Molecular neurobiology 2019-03, Vol.56 (3), p.1681-1693
Hauptverfasser:	Kempuraj, Duraisamy, Thangavel, Ramasamy, Selvakumar, Gvindhasamy Pushpavathi, Ahmed, Mohammad Ejaz, Zaheer, Smita, Raikwar, Sudhanshu P., Zahoor, Haris, Saeed, Daniyal, Dubova, Iuliia, Giler, Gema, Herr, Shelby, Iyer, Shankar S., Zaheer, Asgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - metabolism Basal ganglia Biomedical and Life Sciences Biomedicine Bone marrow Brain Cell Biology Central nervous system diseases Corpus Striatum - metabolism Cytokines Dopamine receptors Enzyme-linked immunosorbent assay Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fetuses Glia maturation factor Glial cells Histamine Humans Inflammation Interleukin-33 - metabolism Kinases Mast cells Mast Cells - metabolism Mesencephalon Mesencephalon - metabolism Mice Microglia Microtubule-associated protein 2 Monocyte chemoattractant protein 1 Movement disorders MPP Neostriatum Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neuronal-glial interactions Neurons - metabolism Neurosciences NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Parkinson Disease - metabolism Parkinson's disease Proteins Reactive oxygen species Rodents Signal Transduction - physiology Tryptases - metabolism
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