Temporal changes in myocardial collagen, matrix metalloproteinases, and their tissue inhibitors in the left ventricular myocardium in experimental chronic mitral regurgitation in rodents

Mitral regurgitation (MR) imposes left ventricular volume overload, triggering rapid ventricular dilatation, increased myocardial compliance, and, ultimately, cardiac dysfunction. Breakdown of the extracellular matrix has been hypothesized to drive these rapid changes, partially from an imbalance in...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2018-11, Vol.315 (5), p.H1269-H1278
Hauptverfasser:	Corporan, Daniella, Onohara, Daisuke, Hernandez-Merlo, Roberto, Sielicka, Alicja, Padala, Muralidhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosynthesis Breakdown Cardiovascular system Collagen Collagen - genetics Collagen - metabolism Disease Models, Animal Echocardiography, Transesophageal Extracellular matrix Gelatinase A Gene expression Gene Expression Regulation Genes Heart Heart Ventricles - diagnostic imaging Heart Ventricles - enzymology Heart Ventricles - physiopathology Inhibitors Interstitial collagenase Male Matrix metalloproteinase Matrix metalloproteinases Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Mechanical ventilation Metalloproteinase Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - enzymology Mitral Valve Insufficiency - genetics Mitral Valve Insufficiency - physiopathology Myocardium Myocardium - enzymology Perforation Proteins Proteolysis Proteolytic enzymes Rats, Sprague-Dawley Regurgitation Rodents Severity of Illness Index Surgery Time Factors Tissue inhibitor of metalloproteinase 1 Tissue inhibitor of metalloproteinase 3 Tissue inhibitor of metalloproteinase 4 Tissue Inhibitor of Metalloproteinases - genetics Tissue Inhibitor of Metalloproteinases - metabolism Tissues Ultrasound Ventilation Ventricle Ventricular Function, Left Ventricular Remodeling
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