UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

The present study aimed to develop novel diagnostic methods for polycystic ovarian syndrome (PCOS) by screening and identifying specific PCOS‑associated metabolic markers using plasma metabolomics. Ultra‑performance liquid chromatography/quadrapole‑time of flight‑mass spectrometry was adopted to est...

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Veröffentlicht in:	Molecular medicine reports 2019-01, Vol.19 (1), p.280-292
Hauptverfasser:	Fan, Xuemei, Jiang, Jianfa, Huang, Zhiqiang, Gong, Jumei, Wang, Yiming, Xue, Wei, Deng, Yan, Wang, Yanfang, Zheng, Tingping, Sun, Aijun, Luo, Guoan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Androgens Apolipoproteins Biological markers Biomarkers - analysis Biomarkers - metabolism Body mass index Care and treatment Case-Control Studies Chromatography Chromatography, Liquid - methods Cyclic GMP Dehydroepiandrosterone Development and progression Female Follicles Guanosine Hemoglobin High density lipoprotein Humans Identification and classification Insulin resistance Lipid metabolism Lipoproteins Liquid chromatography Mass spectrometry Mass spectroscopy Medical diagnosis Menstruation Metabolic disorders Metabolites Metabolomics Metabolomics - methods Pathogenesis Plasma - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - metabolism Proteins ROC Curve Scientific imaging Spectrometry, Mass, Electrospray Ionization - methods Sphingomyelin Statistical analysis Sulfates Triglycerides Ultrasonic imaging Young Adult
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