Effects of glycol-split low molecular weight heparin on placental, endothelial, and anti-inflammatory pathways relevant to preeclampsia

Low molecular weight heparin (LMWH) is being investigated as a potential preventative therapy against preeclampsia. There is evidence suggesting that LMWH may prevent preeclampsia through anticoagulation-independent mechanisms. In this study, we compared the in vitro placental, endothelial, and anti...

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Veröffentlicht in:	Biology of reproduction 2018-11, Vol.99 (5), p.1082-1090
Hauptverfasser:	Wat, Jovian M, Hawrylyshyn, Krista, Baczyk, Dora, Greig, Iain R, Kingdom, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticoagulants Anticoagulants - pharmacology Cell Adhesion - drug effects Comparative analysis Complement Activation - drug effects Dalteparin - pharmacology EDTA Endothelium Factor Xa Female Glycols (Class of compounds) Glycols - chemistry Heparin, Low-Molecular-Weight - chemistry Heparin, Low-Molecular-Weight - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - pathology Humans immunology Inflammation - physiopathology Low molecular weight heparin Molecular biology Molecular weight Phenols (Class of compounds) placenta Placenta - drug effects Placenta - pathology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Preventive medicine Reproductive health Signal Transduction - drug effects Tyrosine Vascular Endothelial Growth Factor Receptor-1 - drug effects Vascular Endothelial Growth Factor Receptor-1 - metabolism
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