Iatrogenic endometriosis harbors somatic cancer-driver mutations

Abstract STUDY QUESTION Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RAS or PI3K-Akt-mTor signaling pathways. WHAT IS KNOWN A...

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Veröffentlicht in:	Human reproduction (Oxford) 2019-01, Vol.34 (1), p.69-78
Hauptverfasser:	Lac, V, Verhoef, L, Aguirre-Hernandez, R, Nazeran, T M, Tessier-Cloutier, B, Praetorius, T, Orr, N L, Noga, H, Lum, A, Khattra, J, Prentice, L M, Co, D, Köbel, M, Mijatovic, V, Lee, A F, Pasternak, J, Bleeker, M C, Krämer, B, Brucker, S Y, Kommoss, F, Kommoss, S, Horlings, H M, Yong, P J, Huntsman, D G, Anglesio, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Canada Carcinogenesis - genetics Disease Progression Endometriosis - etiology Endometriosis - pathology Endometrium - pathology Endometrium - surgery Female Germany Gynecologic Surgical Procedures - adverse effects Humans Iatrogenic Disease Middle Aged Mutation Neoplasms - genetics Neoplasms - pathology Netherlands Original Retrospective Studies Signal Transduction - genetics
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