A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia

: Mutations in the colony-stimulating factor 3 receptor (CSF3R) have been identified in the vast majority of patients with chronic neutrophilic leukemia and are present in other kinds of leukemia, such as acute myeloid leukemia. Here, we studied the function of novel germline variants in CSF3R at am...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-12, Vol.78 (24), p.6762-6770
Hauptverfasser:	Spiciarich, David R, Oh, Stephen T, Foley, Amy, Hughes, Seamus B, Mauro, Michael J, Abdel-Wahab, Omar, Press, Richard D, Viner, Rosa, Thompson, Sarah L, Chen, Qiushi, Azadi, Parastoo, Bertozzi, Carolyn R, Maxson, Julia E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Binding Sites Carcinogenesis Cell Membrane - metabolism Disease Progression Female Gene Expression Regulation, Leukemic Germ-Line Mutation Glycosylation HEK293 Cells Humans Janus Kinases - metabolism Leukemia - genetics Leukemia - metabolism Leukemia, Myeloid, Acute - genetics Leukemia, Neutrophilic, Chronic - genetics Ligands Mass Spectrometry Mice Mice, Inbred C57BL Middle Aged Mutation Proteomics Receptors, Colony-Stimulating Factor - genetics Receptors, Colony-Stimulating Factor - metabolism Sequence Analysis, DNA Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization STAT Transcription Factors - metabolism
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