Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In , HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to con...
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| Veröffentlicht in: | Genes & development 2018-12, Vol.32 (23-24), p.1562-1575 |
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| creator | Son, Heehwa G Seo, Keunhee Seo, Mihwa Park, Sangsoon Ham, Seokjin An, Seon Woo A Choi, Eun-Seok Lee, Yujin Baek, Haeshim Kim, Eunju Ryu, Youngjae Ha, Chang Man Hsu, Ao-Lin Roh, Tae-Young Jang, Sung Key Lee, Seung-Jae V |
| description | Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In
, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS. |
| doi_str_mv | 10.1101/gad.317362.118 |
| format | Article |
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, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.</description><identifier>ISSN: 0890-9369</identifier><identifier>EISSN: 1549-5477</identifier><identifier>DOI: 10.1101/gad.317362.118</identifier><identifier>PMID: 30478249</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - metabolism ; Caenorhabditis elegans Proteins - metabolism ; Forkhead Transcription Factors - metabolism ; Insulin - metabolism ; Insulin-Like Growth Factor I - metabolism ; Intestines - physiology ; Longevity - genetics ; Molecular Chaperones - genetics ; Molecular Chaperones - metabolism ; Protein Binding ; Research Paper ; Signal Transduction - genetics ; Subcutaneous Tissue - physiology ; Transcription Factors - metabolism ; Transcriptional Activation - genetics</subject><ispartof>Genes & development, 2018-12, Vol.32 (23-24), p.1562-1575</ispartof><rights>2018 Son et al.; Published by Cold Spring Harbor Laboratory Press.</rights><rights>2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-9df46771e25de27c922f3f89e9b430695daaefe3f3c08cb5895793c2858673d33</citedby><cites>FETCH-LOGICAL-c390t-9df46771e25de27c922f3f89e9b430695daaefe3f3c08cb5895793c2858673d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30478249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Heehwa G</creatorcontrib><creatorcontrib>Seo, Keunhee</creatorcontrib><creatorcontrib>Seo, Mihwa</creatorcontrib><creatorcontrib>Park, Sangsoon</creatorcontrib><creatorcontrib>Ham, Seokjin</creatorcontrib><creatorcontrib>An, Seon Woo A</creatorcontrib><creatorcontrib>Choi, Eun-Seok</creatorcontrib><creatorcontrib>Lee, Yujin</creatorcontrib><creatorcontrib>Baek, Haeshim</creatorcontrib><creatorcontrib>Kim, Eunju</creatorcontrib><creatorcontrib>Ryu, Youngjae</creatorcontrib><creatorcontrib>Ha, Chang Man</creatorcontrib><creatorcontrib>Hsu, Ao-Lin</creatorcontrib><creatorcontrib>Roh, Tae-Young</creatorcontrib><creatorcontrib>Jang, Sung Key</creatorcontrib><creatorcontrib>Lee, Seung-Jae V</creatorcontrib><title>Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans</title><title>Genes & development</title><addtitle>Genes Dev</addtitle><description>Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In
, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.</description><subject>Animals</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Caenorhabditis elegans Proteins - metabolism</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Insulin - metabolism</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Intestines - physiology</subject><subject>Longevity - genetics</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - metabolism</subject><subject>Protein Binding</subject><subject>Research Paper</subject><subject>Signal Transduction - genetics</subject><subject>Subcutaneous Tissue - physiology</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Activation - genetics</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1LAzEUDKLYWr16lBy9bM3Hbj4ughSrQqEeVLyFNPvSrm43NdkW-u_dUi16egxv3rxhBqFLSoaUEnozt-WQU8kF67A6Qn1a5DorcimPUZ8oTTLNhe6hs5Q-CCGCCHGKepzkUrFc99HbcwQf6rJqsMBLKCvbQsJ1aOawqdotjpBWoUmAfQxLvADb4rQI7hN769oQMcVtwOPp-xR3CqMhhhrmtknn6MTbOsHFzxyg1_H9y-gxm0wfnkZ3k8xxTdpMlz4XUlJgRQlMOs2Y515p0LOcE6GL0lrwwD13RLlZoXQhNXdMFUpIXnI-QLd73dV61rl30LTR1mYVq6WNWxNsZf5vmmph5mFjBNMFFTuB6x-BGL7WkFqzrJKDurYNhHUyjHIlcpUT3VGHe6qLIaUutsMbSsyuDNOVYfZldFh1B1d_zR3ov-nzb7fOhVg</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Son, Heehwa G</creator><creator>Seo, Keunhee</creator><creator>Seo, Mihwa</creator><creator>Park, Sangsoon</creator><creator>Ham, Seokjin</creator><creator>An, Seon Woo A</creator><creator>Choi, Eun-Seok</creator><creator>Lee, Yujin</creator><creator>Baek, Haeshim</creator><creator>Kim, Eunju</creator><creator>Ryu, Youngjae</creator><creator>Ha, Chang Man</creator><creator>Hsu, Ao-Lin</creator><creator>Roh, Tae-Young</creator><creator>Jang, Sung Key</creator><creator>Lee, Seung-Jae V</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans</title><author>Son, Heehwa G ; Seo, Keunhee ; Seo, Mihwa ; Park, Sangsoon ; Ham, Seokjin ; An, Seon Woo A ; Choi, Eun-Seok ; Lee, Yujin ; Baek, Haeshim ; Kim, Eunju ; Ryu, Youngjae ; Ha, Chang Man ; Hsu, Ao-Lin ; Roh, Tae-Young ; Jang, Sung Key ; Lee, Seung-Jae V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-9df46771e25de27c922f3f89e9b430695daaefe3f3c08cb5895793c2858673d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - metabolism</topic><topic>Caenorhabditis elegans Proteins - metabolism</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Insulin - metabolism</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Intestines - physiology</topic><topic>Longevity - genetics</topic><topic>Molecular Chaperones - genetics</topic><topic>Molecular Chaperones - metabolism</topic><topic>Protein Binding</topic><topic>Research Paper</topic><topic>Signal Transduction - genetics</topic><topic>Subcutaneous Tissue - physiology</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptional Activation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, Heehwa G</creatorcontrib><creatorcontrib>Seo, Keunhee</creatorcontrib><creatorcontrib>Seo, Mihwa</creatorcontrib><creatorcontrib>Park, Sangsoon</creatorcontrib><creatorcontrib>Ham, Seokjin</creatorcontrib><creatorcontrib>An, Seon Woo A</creatorcontrib><creatorcontrib>Choi, Eun-Seok</creatorcontrib><creatorcontrib>Lee, Yujin</creatorcontrib><creatorcontrib>Baek, Haeshim</creatorcontrib><creatorcontrib>Kim, Eunju</creatorcontrib><creatorcontrib>Ryu, Youngjae</creatorcontrib><creatorcontrib>Ha, Chang Man</creatorcontrib><creatorcontrib>Hsu, Ao-Lin</creatorcontrib><creatorcontrib>Roh, Tae-Young</creatorcontrib><creatorcontrib>Jang, Sung Key</creatorcontrib><creatorcontrib>Lee, Seung-Jae V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Heehwa G</au><au>Seo, Keunhee</au><au>Seo, Mihwa</au><au>Park, Sangsoon</au><au>Ham, Seokjin</au><au>An, Seon Woo A</au><au>Choi, Eun-Seok</au><au>Lee, Yujin</au><au>Baek, Haeshim</au><au>Kim, Eunju</au><au>Ryu, Youngjae</au><au>Ha, Chang Man</au><au>Hsu, Ao-Lin</au><au>Roh, Tae-Young</au><au>Jang, Sung Key</au><au>Lee, Seung-Jae V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>32</volume><issue>23-24</issue><spage>1562</spage><epage>1575</epage><pages>1562-1575</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In
, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>30478249</pmid><doi>10.1101/gad.317362.118</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genes & development, 2018-12, Vol.32 (23-24), p.1562-1575 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Forkhead Transcription Factors - metabolism Insulin - metabolism Insulin-Like Growth Factor I - metabolism Intestines - physiology Longevity - genetics Molecular Chaperones - genetics Molecular Chaperones - metabolism Protein Binding Research Paper Signal Transduction - genetics Subcutaneous Tissue - physiology Transcription Factors - metabolism Transcriptional Activation - genetics |
| title | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
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