Citrate-based materials fuel human stem cells by metabonegenic regulation

A comprehensive understanding of the key microenvironmental signals regulating bone regeneration is pivotal for the effective design of bioinspired orthopedic materials. Here, we identified citrate as an osteopromotive factor and revealed its metabonegenic role in mediating citrate metabolism and it...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-12, Vol.115 (50), p.E11741-E11750
Hauptverfasser:	Ma, Chuying, Tian, Xinggui, Kim, Jimin P., Xie, Denghui, Ao, Xiang, Shan, Dingying, Lin, Qiaoling, Hudock, Maria R., Bai, Xiaochun, Yang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biocompatibility Biodegradability Biodegradation Biological Sciences Biomaterials Biomedical materials Biomimetics Bone growth Citric acid Composite materials Differentiation (biology) Downstream effects Energy balance Femur Fluorescence Hydroxyapatite Mesenchyme Metabolic pathways Metabolism Microenvironments Orthopedics Phosphorus Phosphoserine Photoluminescence Physical Sciences PNAS Plus Regeneration Regeneration (physiology) Stem cell transplantation Stem cells Surgical implants Tissue engineering
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