CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1

Natural killer (NK) cell recognition of tumor cells is mediated through activating receptors such as CD226, with suppression of effector functions often controlled by negative regulatory transcription factors such as FOXO1. Here we show that CD226 regulation of NK cell cytotoxicity is facilitated th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-12, Vol.115 (50), p.E11731-E11740
Hauptverfasser:	Du, Xiangnan, de Almeida, Patricia, Manieri, Nick, de Almeida Nagata, Denise, Wu, Thomas D., Bowles, Kristin Harden, Arumugam, Vidhyalakshmi, Schartner, Jill, Cubas, Rafael, Mittman, Stephanie, Javinal, Vincent, Anderson, Keith R., Warming, Søren, Grogan, Jane L., Chiang, Eugene Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - metabolism Antitumor activity Biological Sciences Cell Line, Tumor Cell recognition Cells Cytotoxicity Cytotoxicity, Immunologic Deactivation Forkhead Box Protein O1 - antagonists & inhibitors Forkhead Box Protein O1 - metabolism FOXO1 protein Gene expression Gene Expression Regulation, Neoplastic Humans Inactivation Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Mice Mice, Knockout Natural killer cells Nectins - metabolism Phosphorylation PNAS Plus Receptors Receptors, Virus - metabolism Signal Transduction - immunology Toxicity Transcription factors Tumor cells Tumors
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