Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were re...
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| creator | Xargay-Torrent, Sílvia Espuña-Capote, Núria Montesinos-Costa, Mercè Prats-Puig, Anna Carreras-Badosa, Gemma Díaz-Roldán, Ferran De Zegher, Francis Ibáñez, Lourdes Bassols, Judit López-Bermejo, Abel |
| description | Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (
p
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| doi_str_mv | 10.1038/s41598-018-35973-5 |
| format | Article |
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p
< 0.0001), waist circumference (
p
< 0.0001), SBP (
p
< 0.0001), cIMT (
p
= 0.005), HOMA-IR (
p
< 0.0001), and fasting triglycerides (
p
= 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231;
p
= 0.001), waist (r = 0.252;
p
< 0.0001), SBP (r = 0.324;
p
< 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291;
p
< 0.0001)]. ALP independently associated with SBP (β = 0.290,
p
< 0.001) and cIMT (β = 0.179,
p
= 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.]]></description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-35973-5</identifier><identifier>PMID: 30552346</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743 ; 692/308/53 ; 82/56 ; Alkaline phosphatase ; Alkaline Phosphatase - blood ; Atherosclerosis - epidemiology ; Atherosclerosis - pathology ; Blood Chemical Analysis ; Blood pressure ; Calcium ; Calcium - blood ; Cardiovascular diseases ; Carotid Intima-Media Thickness ; Child ; Children ; Cross-Sectional Studies ; Health risk assessment ; Health risks ; Humanities and Social Sciences ; Humans ; Insulin ; Lipids ; multidisciplinary ; Phosphatase ; Phosphorus ; Phosphorus - blood ; Risk Assessment ; Science ; Science (multidisciplinary) ; Serum - chemistry ; Triglycerides</subject><ispartof>Scientific reports, 2018-12, Vol.8 (1), p.17864-7, Article 17864</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-731438b46ad93f4c42830086bc2033aa76074e8bd06c3b6614d23823497f25f23</citedby><cites>FETCH-LOGICAL-c522t-731438b46ad93f4c42830086bc2033aa76074e8bd06c3b6614d23823497f25f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294743/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294743/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30552346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xargay-Torrent, Sílvia</creatorcontrib><creatorcontrib>Espuña-Capote, Núria</creatorcontrib><creatorcontrib>Montesinos-Costa, Mercè</creatorcontrib><creatorcontrib>Prats-Puig, Anna</creatorcontrib><creatorcontrib>Carreras-Badosa, Gemma</creatorcontrib><creatorcontrib>Díaz-Roldán, Ferran</creatorcontrib><creatorcontrib>De Zegher, Francis</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><creatorcontrib>Bassols, Judit</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><title>Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description><![CDATA[Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (
p
< 0.0001), waist circumference (
p
< 0.0001), SBP (
p
< 0.0001), cIMT (
p
= 0.005), HOMA-IR (
p
< 0.0001), and fasting triglycerides (
p
= 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231;
p
= 0.001), waist (r = 0.252;
p
< 0.0001), SBP (r = 0.324;
p
< 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291;
p
< 0.0001)]. ALP independently associated with SBP (β = 0.290,
p
< 0.001) and cIMT (β = 0.179,
p
= 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.]]></description><subject>692/163/2743</subject><subject>692/308/53</subject><subject>82/56</subject><subject>Alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Atherosclerosis - epidemiology</subject><subject>Atherosclerosis - pathology</subject><subject>Blood Chemical Analysis</subject><subject>Blood pressure</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Cardiovascular diseases</subject><subject>Carotid Intima-Media Thickness</subject><subject>Child</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Insulin</subject><subject>Lipids</subject><subject>multidisciplinary</subject><subject>Phosphatase</subject><subject>Phosphorus</subject><subject>Phosphorus - 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blood</topic><topic>Atherosclerosis - epidemiology</topic><topic>Atherosclerosis - pathology</topic><topic>Blood Chemical Analysis</topic><topic>Blood pressure</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Cardiovascular diseases</topic><topic>Carotid Intima-Media Thickness</topic><topic>Child</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Insulin</topic><topic>Lipids</topic><topic>multidisciplinary</topic><topic>Phosphatase</topic><topic>Phosphorus</topic><topic>Phosphorus - blood</topic><topic>Risk Assessment</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serum - chemistry</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xargay-Torrent, Sílvia</creatorcontrib><creatorcontrib>Espuña-Capote, Núria</creatorcontrib><creatorcontrib>Montesinos-Costa, Mercè</creatorcontrib><creatorcontrib>Prats-Puig, Anna</creatorcontrib><creatorcontrib>Carreras-Badosa, Gemma</creatorcontrib><creatorcontrib>Díaz-Roldán, Ferran</creatorcontrib><creatorcontrib>De Zegher, Francis</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><creatorcontrib>Bassols, Judit</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xargay-Torrent, Sílvia</au><au>Espuña-Capote, Núria</au><au>Montesinos-Costa, Mercè</au><au>Prats-Puig, Anna</au><au>Carreras-Badosa, Gemma</au><au>Díaz-Roldán, Ferran</au><au>De Zegher, Francis</au><au>Ibáñez, Lourdes</au><au>Bassols, Judit</au><au>López-Bermejo, Abel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-12-14</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>17864</spage><epage>7</epage><pages>17864-7</pages><artnum>17864</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract><![CDATA[Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (
p
< 0.0001), waist circumference (
p
< 0.0001), SBP (
p
< 0.0001), cIMT (
p
= 0.005), HOMA-IR (
p
< 0.0001), and fasting triglycerides (
p
= 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231;
p
= 0.001), waist (r = 0.252;
p
< 0.0001), SBP (r = 0.324;
p
< 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291;
p
< 0.0001)]. ALP independently associated with SBP (β = 0.290,
p
< 0.001) and cIMT (β = 0.179,
p
= 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30552346</pmid><doi>10.1038/s41598-018-35973-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/163/2743 692/308/53 82/56 Alkaline phosphatase Alkaline Phosphatase - blood Atherosclerosis - epidemiology Atherosclerosis - pathology Blood Chemical Analysis Blood pressure Calcium Calcium - blood Cardiovascular diseases Carotid Intima-Media Thickness Child Children Cross-Sectional Studies Health risk assessment Health risks Humanities and Social Sciences Humans Insulin Lipids multidisciplinary Phosphatase Phosphorus Phosphorus - blood Risk Assessment Science Science (multidisciplinary) Serum - chemistry Triglycerides |
| title | Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product |
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