CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth

Krüppel‐like factor 5 (KLF5) both suppresses and promotes tumor growth depending on cellular context. The mechanisms underlying tumor promotion could be targetable for therapy. Although a number of transcriptional targets of KLF5 have been identified and implicated in KLF5‐mediated tumor growth, how...

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Veröffentlicht in:	International journal of cancer 2019-02, Vol.144 (3), p.582-594
Hauptverfasser:	Wu, Qiao, Fu, Changying, Li, Menglin, Li, Juan, Li, Zhigui, Qi, Leilei, Ci, Xinpei, Ma, Gui, Gao, Ang, Fu, Xing, A, Jun, An, Na, Liu, Mingcheng, Li, Yixiang, King, Jamie L., Fu, Liya, Zhang, Baotong, Dong, Jin‐Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bladder cancer Cancer Carrier Proteins - genetics Carrier Proteins - metabolism Caspase Caspase-7 Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Cell survival Cyclin D1 cyclin‐dependent kinase 2‐interacting protein HEK293 Cells HeLa Cells Heterografts Humans Immunohistochemistry Immunoprecipitation Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Krüppel‐like factor 5 Liquid chromatography Male Mass spectrometry Mass spectroscopy MCF-7 Cells Medical research Mice, Inbred BALB C Mice, Nude Promotion Proteins Therapeutic applications Transcription Tumorigenesis Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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