Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization

Abstract Constitutive heterochromatin undergoes a dynamic clustering and spatial reorganization during myogenic differentiation. However the detailed mechanisms and its role in cell differentiation remain largely elusive. Here, we report the identification of a muscle-specific long non-coding RNA, C...

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Veröffentlicht in:	Nucleic acids research 2018-12, Vol.46 (22), p.11759-11775
Hauptverfasser:	Park, Jinyoung, Lee, Hongmin, Han, Namshik, Kwak, Sojung, Lee, Han-Teo, Kim, Jae-Hwan, Kang, Keonjin, Youn, Byoung Ha, Yang, Jae-Hyun, Jeong, Hyeon-Ju, Kang, Jong-Sun, Kim, Seon-Young, Han, Jeung-Whan, Youn, Hong-Duk, Cho, Eun-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Co-Repressor Proteins Cohesins CRISPR-Cas Systems Female Gene Editing Gene Expression Regulation, Developmental Gene regulation, Chromatin and Epigenetics HEK293 Cells Heterochromatin - chemistry Heterochromatin - metabolism Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones - genetics Histones - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism Mice Mice, Inbred C57BL Molecular Chaperones Muscle Development - genetics Muscle, Skeletal - cytology Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism NIH 3T3 Cells Nuclear Proteins - genetics Nuclear Proteins - metabolism RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transcription, Genetic X-linked Nuclear Protein - genetics X-linked Nuclear Protein - metabolism
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